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ILETIN® ILETIN® II PORK Lilly Insulin Diabetes Mellitus Therapy Description: Insulin is a protein hormone secreted by the beta cells of the pancreatic islets of Langerhans. The administration of suitable doses of insulin to patients with diabetes mellitus, along with controlled diet and exercise, temporarily restores their ability to metabolize carbohydrates, fats and proteins; to store glycogen in the liver; and to convert glucose to fat. When given in suitable…

IFEX® Bristol Ifosfamide Antineoplastic Agent Caution: Ifosfamide is a potent drug and should be used only by physicians experienced with cancer chemotherapeutic drugs (see Warnings and Precautions). In those patients who develop bacterial, fungal or viral infections, interruption or modification of dosage should be considered. Blood counts should be taken at regular intervals. Due to the urotoxic effect of oxazaphosphorines, ifosfamide should not be administered without the use of a…

ILOSONE® Lilly Erythromycin Estolate Antibiotic Action And Clinical Pharmacology: Erythromycin exerts its antibacterial action by binding the 50S ribosomal subunit of susceptible bacteria and suppressing protein synthesis. Erythromycin is usually bacteriostatic but may be bactericidal in high concentrations or against highly susceptible organisms. Indications And Clinical Uses: For the treatment of infections caused by susceptible strains of the designated microorganisms in the diseases listed below: Upper respiratory tract infections of…

IMDUR® Astra Isosorbide-5-Mononitrate Antianginal Action And Clinical Pharmacology: As with other organic nitrates, the principal pharmacological action of isosorbide-5-mononitrate, the major active metabolite of isosorbide dinitrate (ISDN), is relaxation of vascular smooth muscle and consequent dilation of peripheral arteries and veins, especially the latter. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge…

HYZAAR® MSD Losartan Potassium – Hydrochlorothiazide Angiotensin II Receptor Antagonist – Diuretic Action And Clinical Pharmacology: Hyzaar combines the actions of losartan potassium, an angiotensin II receptor antagonist, and that of a thiazide diuretic, hydrochlorothiazide. Losartan: Losartan antagonizes angiotensin II by blocking the angiotensin type 1 (AT1) receptor. Angiotensin II is the primary vasoactive hormone of the renin-angiotensin system. Its effects include vasoconstriction and the stimulation of aldosterone secretion by…

IDARAC® Sanofi Floctafenine Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Floctafenine, an anthranilic acid derivative, is a nonsteroidal anti-inflammatory agent with analgesic and anti-inflammatory properties. The analgesic activity is comparable to that of other mild analgesics in the relief of acute pain. Floctafenine has been shown to inhibit in vitro biosynthesis of prostaglandins PGE2 and PGF2a. Gastrointestinal bleeding determined by daily fecal blood loss, was shown in one clinical trial…

HYSKON® Medisan Pharmaceuticals Dextran 70 (32% w/v) in Dextrose Hysteroscopy Fluid Indications And Clinical Uses: For use with the hysteroscope as an aid in distending the uterine cavity and in irrigating and visualizing its surfaces. Contra-Indications: Hypersensitivity to dextran. Contraindications relative to the hysteroscopic procedure itself (e.g., pregnancy, endometrial carcinoma). Precautions: When large amounts of Hyskon are employed for hysteroscopy, the possible occurrence of systemic adverse effects including plasma volume…

HYPERSTAT® I.V. INJECTION Schering Diazoxide Antihypertensive Action And Clinical Pharmacology: Diazoxide injection produces a prompt reduction in blood pressure by relaxing smooth muscle in the peripheral arterioles. Cardiac output is increased as blood pressure is reduced by diazoxide; coronary and cerebral blood flow are maintained. Renal blood flow is increased after an initial decrease. Diazoxide has no known direct action on the CNS. Patients refractory to other antihypertensive agents usually…

HYTRIN® Abbott Terazosin HCl Antihypertensive – Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH) Action And Clinical Pharmacology: Hypertension: The antihypertensive effect of terazosin is believed to be a direct result of peripheral vasodilation. Although the exact mechanism by which the lowering of blood pressure is achieved is not known, the relaxation of the vessels appears to be produced mainly by selective blockade of alpha-1-adrenoceptors. Benign Prostatic Hyperplasia (BPH): The reduction…

HYTAKEROL® Sanofi Dihydrotachysterol Antitetany Steroid Action And Clinical Pharmacology: Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1,25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of…