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M.C.T.® OIL Mead Johnson Medium Chain Triglycerides Oil Fat Modified Diets Indications And Clinical Uses: A dietary supplement for use in the nutritional management of children and adults who cannot efficiently digest and absorb conventional long chain food fats. Precautions: In persons with advanced cirrhosis of the liver, large amounts of medium chain triglycerides in the diet may result in elevated blood and spinal fluid levels of medium chain fatty…

M-ESLON® Rh´ne-Poulenc Rorer Morphine Sulfat Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the…

MYCOBUTIN® Pharmacia & Upjohn Rifabutin Antibacterial Agent Action And Clinical Pharmacology: Rifabutin is a derivative of rifamycin S, belonging to the class of ansamycins. The rifamycins owe their antimycobacterial efficacy to their ability to penetrate the cell wall and to their ability to complex with and to inhibit DNA-dependent RNA polymerase. Rifabutin has been found to interact with and to penetrate the outer layers of the mycobacterial envelope. Rifabutin inhibits…

MYCIGUENT® Pharmacia & Upjohn Neomycin Sulfate Topical Antibiotic Indications And Clinical Uses: The prevention and treatment of infection in minor skin breaks caused by cuts, scratches, burns and other injuries. Contra-Indications: Neomycin sensitivity. Precautions: Articles in current medical literature indicate an increase in the incidence of patients sensitive to neomycin. The possibility of such a reaction should be borne in mind. Discontinue use if sensitization occurs. As with any antibiotic…

MYCOSTATIN® Preparations Squibb Nystatin Antifungal Antibiotic Indications And Clinical Uses: Oral: Prevention and treatment of fun of the oral cavity and esophagus, for intestinal candidiasis and for protection against candidal overgrowth during antimicrobial or corticosteroid therapy. Topical: Treatment of cutaneous or mucocutaneous mycotic infections caused by Candida (Monilia) species. Vaginal: Local treatment of vaginal mycotic infections caused by C. albicans (Monilia) and other Candida species and treatment of pregnant patients…

MYLANTA™ Preparations Warner-Lambert Consumer Healthcare Aluminum Hydroxide – Magnesium Hydroxide Compound Antacid – Antiflatulent Indications And Clinical Uses: The treatment and relief of symptoms of peptic ulcer, gastritis, hiatus hernia, hyperacidity, and the management of gastrointestinal disorders accompanied by excessive gas or flatus. Contra-Indications: Alkalosis, hypermagnesemia, where distention may be due to partial or complete intestinal obstruction. Not recommended for severely debilitated patients or those with impaired renal function. Precautions:…

MYOCHRYSINE® Rh´ne-Poulenc Rorer Sodium Aurothiomalate Antirheumatic Agent Action And Clinical Pharmacology: Sodium aurothiomalate exhibits anti-inflammatory, antiarthritic and immunomodulating effects. The predominant clinical effect of sodium aurothiomalate appears to be suppression of the synovitis in the active stage of the rheumatoid disease. The precise mechanism of action is unknown but it has been suggested that the drug may act by inhibiting cell-mediated and humoral immune mechanisms. Additional modes of action include…

LUTREPULSE™ Ferring Gonadorelin Acetate Ovulatory Agent Action And Clinical Pharmacology: Gonadorelin is a synthetic decapeptide that has the same amino acid sequence as endogenous gonadotropin-releasing hormone (GnRH) synthesized in the human hypothalamus and in various neurons terminating in the hypothalamus. Its pharmacological and toxicological profile is therefore identical to that of endogenous GnRH. Under physiologic conditions, GnRH is released by the hypothalamus in a pulsatile fashion. The primary effect of…

LUVOX® Solvay Pharma Fluvoxamine Maleate Antidepressant – Antiobsessional Agent Action And Clinical Pharmacology: The antidepressant and antiobsessional actions of fluvoxamine are believed to be related to its selective inhibition of presynaptic serotonin re-uptake in brain neurones. There is minimum interference with noradrenergic processes, and, in common with several other specific inhibitors of serotonin uptake, fluvoxamine has very little in vitro affinity for a1, a2, b1, dopamine2, histamine1, serotonin1, serotonin2 or…

LYSODREN Bristol Mitotane Antineoplastic Action And Clinical Pharmacology: Mitotane is an adrenal cytotoxic agent, and can cause adrenal inhibition, apparently without cellular destruction. Its biochemical mechanism of action is unknown. Available data suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex. In man, mitotane administration alters cortisol’s extra-adrenal metabolism, leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma corticosteroid…