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MUSTARGEN® MSD Mechlorethamine HCl Alkylating Agent Action And Clinical Pharmacology: Mechlorethamine, a biologic alkylating agent, has a cytotoxic action which inhibits rapidly proliferating cells. tag_IndicationsIndications Indications And Clinical Uses: Before using mechlorethamine see Contraindications, Warnings, Precautions, Adverse Effects and Dosage. Administered i.v., mechlorethamine is indicated for the palliative treatment of Hodgkin’s disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides and bronchogenic carcinoma….

MUTACOL BERNA® Berna Products Cholera Vaccine Live Oral CVD 103-HgR Cholera Prophylaxis Action And Clinical Pharmacology: V. cholerae is the etiological agent of cholera, an acute diarrheal disease. This vaccine will not afford protection against species of vibrio other than 01 V. cholerae or against other bacteria that cause enteric disease. Mutacol Berna vaccine will not afford protection against 0139 V. cholerae. There are less than 30 cases of cholera…

MUTAMYCIN® Bristol Mitomycin Antineoplastic Action And Clinical Pharmacology: Mitomycin was investigated at first as an antibiotic in Japan. It was then found to be active as an antineoplastic agent. It selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The exact point of mitomycin attachment to DNA remains unknown. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Mitomycin is rapidly cleared from the plasma after…

MUCAINE® Axcan Pharma Oxethazaine – Aluminum Hydroxide – Magnesium Hydroxide Antacid – Mucosal Anesthetic Action And Clinical Pharmacology: Alumina gel and magnesium hydroxide react chemically to neutralize or buffer existing quantities of stomach acid but have no direct effect on its production. This action increases gastric pH, providing symptomatic relief of hyperacidity. Gastroscopic observations reveal that alumina gel, especially when swallowed undiluted, forms a diffuse coating over the inflamed gastric…

MULTITEST® CMI Connaught Skin Test Antigens for Cell-Mediated Immunity Diagnostic Aid Action And Clinical Pharmacology: The delayed cutaneous responses associated with the ubiquitous antigens in the Multitest battery appear to be typical cellular hypersensitivity reactions. A relatively small amount of soluble antigen is introduced into the epidermia and superficial dermal tissue by puncture. Circulating T-cells (lymphocytes), sensitized to the antigen from prior contact, react with the antigens in the skin…

MUCOMYST® Roberts Acetylcysteine Mucolytic – Antidote for Acetaminophen Poisoning Action And Clinical Pharmacology: The viscosity of pulmonary mucous secretions depends on the concentrations of mucoprotein and to a lesser extent deoxyribonucleic acid (DNA). The latter increases with increasing purulence owing to cellular debris. The mucolytic action of acetylcysteine is related to the sulfhydryl group in the molecule. This group probably “opens” disulfide linkages in mucus thereby lowering the viscosity. The…

MOTRIN® IB McNeil Consumer Products Ibuprofen Analgesic – Antipyretic – Anti-inflammatory Action And Clinical Pharmacology: Ibuprofen is a member of the class of agents commonly known as nonsteroidal anti-inflammatory drugs (NSAIDs). Consistent with this classification, ibuprofen exhibits anti-inflammatory activity at higher dosage ranges. At lower adult single doses relevant to a 200 mg dosage strength (200 to 400 mg) ibuprofen relieves pain of mild to moderate intensity and reduces fever….

MOTRIN® Pharmacia & Upjohn Ibuprofen Anti-inflammatory – Analgesic – Antipyretic Action And Clinical Pharmacology: Ibuprofen has demonstrated anti-inflammatory, analgesic and antipyretic activity in animal studies designed to specifically demonstrate these effects. Its mode of action, like that of other nonsteroidal anti-inflammatory agents, is not completely understood, but may be related to prostaglandin synthetase inhibition. Ibuprofen does not alter the course of the underlying disease. Ibuprofen has no demonstrable glucocorticoid effect….

MS•IR® Purdue Frederick Morphine Sulfate Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the…

MS CONTIN® Purdue Frederick Morphine Sulfate Opioid Analgesic Action And Clinical Pharmacology: Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of…