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NESACAINE®-CE Astra Chloroprocaine HCl Local Anesthetic Action And Clinical Pharmacology: Chloroprocaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthetic action. The onset of action is rapid (usually within 6 to 12 minutes). The duration of anesthesia depends on the procedure and the amount used, but could last up to 60 minutes. Chloroprocaine is rapidly hydrolyzed in plasma by pseudocholinesterase. This hydrolysis…

NEUPOGEN® Amgen Filgrastim Granulocyte Colony Stimulating Factor – Hematopoietic Agent Action And Clinical Pharmacology: Filgrastim is a human granulocyte colony stimulating factor (G-CSF) produced by recombinant DNA technology. G-CSF regulates the production of neutrophils within the bone marrow; endogenous G-CSF is a glycoprotein produced by monocytes, fibroblasts, and endothelial cells. G-CSF is a colony stimulating factor which has been shown to have minimal direct in vivo or in vitro effects…

NERISALIC® Stiefel Diflucortolone Valerate – Salicylic Acid Topical Corticosteroid – Keratolytic Action And Clinical Pharmacology: Nerisalic combines the anti-inflammatory, antipruritic and vasoconstrictive activity of diflucortolone valerate and the keratolytic effects of salicylic acid. Both diflucortolone valerate and its split ester are topically active. Indications And Clinical Uses: The topical treatment of chronic eczema, psoriasis vulgaris, neuro-dermatitis and scaly crusty dermatoses which respond to corticosteroid therapy. Nerisalic is not suitable for…

NEOSPORIN® Preparations Glaxo Wellcome Polymyxin B – Neomycin Compound Antibiotic Indications And Clinical Uses: Cream: Infection in dermatologic disorders particularly where the lesions are moist or weeping. Prophylactically, against bacterial contamination in burns, skin grafts, incisions and other clean lesions. For abrasions, minor cuts and wounds, the cream may prevent infection and permit normal healing. Irrigating Solution: To be diluted and used as a continuous irrigant or rinse for short-term…

NEO-MEDROL® Acne Lotion Pharmacia & Upjohn Methylprednisolone – Neomycin Compound Acne Therapy Indications And Clinical Uses: For control of acne vulgaris in the adolescent and young adult. Also in some cases of acne rosacea and seborrheic dermatitis. Contra-Indications: In tuberculosis of the skin, herpes simplex, vaccinia, varicella and in other cutaneous infections which do not respond to neomycin. Known hypersensitivity to any of the components. Precautions: Avoid contact with eyes….

NEO-CORTEF® Preparations Pharmacia & Upjohn Neomycin Sulfate – Hydrocortisone Acetate Antibiotic – Corticosteroid Indications And Clinical Uses: These preparations are indicated in the following conditions when threatened with or complicated by infection due to neomycin sensitive organisms. Eye Drops: phlyctenular kerato-conjunctivitis, nonspecific superficial keratitis, acne rosacea keratitis, allergic conjunctivitis, sclerokeratitis, episcleritis, traumatic keratitis. In generalized uveitis and inflammatory diseases of the posterior segment, systemic corticosteroid therapy should be employed. Ointment:…

NEORAL® SANDIMMUNE® I.V. Novartis Cyclosporine Immunosuppressant Caution: Transplantation: Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe Neoral and Sandimmune I.V. Patients receiving the drug should be managed in centres staffed with professionals experienced in transplantation and the use of immunosuppressants and equipped with adequate laboratory facilities to monitor cyclosporine levels. The ability to measure cyclosporine blood levels facilitates the management of the patient. The…

NASACORT™ Rhône-Poulenc Rorer Triamcinolone Acetonide Corticosteroid Action And Clinical Pharmacology: Triamcinolone is a potent anti-inflammatory steroid with strong topical and weak systemic activity. When administered intranasally in therapeutic doses, it has a direct anti-inflammatory action on the nasal mucosa, the mechanism of which is not yet completely defined. The minute amount absorbed in therapeutic doses has not been shown to exert any apparent clinical systemic effects. Indications And Clinical Uses:…

NAVANE™ Pfizer Thiothixene Antipsychotic Action And Clinical Pharmacology: Thiothixene is an antipsychotic agent of the thioxanthene series. It possesses certain chemical and pharmacologic similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Thiothixene’s mode of action has not been clearly established. Indications And Clinical Uses: An antipsychotic agent useful in the management of schizophrenia and other psychotic disorders. As with other antipsychotic agents, some patients resistant…

NAVELBINE® Glaxo Wellcome Vinorelbine Tartrate Antineoplastic Action And Clinical Pharmacology: Vinorelbine is a novel vinca alkaloid which interferes with microtubule assembly. Vinca alkaloids are structurally similar compounds comprising two multiringed units, vindoline and catharanthine. Vinorelbine is a vinca alkaloid in which the catharanthine unit is the site of structural modification. This structural change imparts unique pharmacologic properties which may translate into clinical benefits for patients with various malignancies. The antitumor…