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NOLVADEX® NOLVADEX®-D Zeneca Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen, the active ingredient, is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to its ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA), and causes the regression of already established…

NITROLINGUAL® PUMPSPRAY Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely, relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demand rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation…

NITRONG® SR Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of Nitrong (nitroglycerin) is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demands rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds….

NITROSTAT™ Parke-Davis Nitroglycerin Coronary Vasodilator Indications And Clinical Uses: For the prophylaxis, treatment and management of patients with angina pectoris. Contra-Indications: In patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to nitroglycerin. Manufacturers’ Warnings In Clinical States: The use of nitroglycerin during the early course of acute myocardial infarction requires particular attention to hemodynamic monitoring and clinical status because of the possibility…

NITRO-DUR® Key Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilation of both peripheral arteries and veins, with more prominent effects on the latter. Dilation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance and…

NITROGLYCERIN General Monograph, CPhA Glyceryl Trinitrate Antianginal – Antihypertensive Pharmacology: Nitroglycerin, in common with other nitrates, produces generalized vasodilation, thereby decreasing venous return and workload on the heart. Both arterial and venous dilation occur, although venous effects predominate. Coronary vasodilation also occurs even in the presence of atherosclerosis. Relaxation of vascular smooth muscle is a result of stimulation of cyclic guanosine monophosphate (GMP) production as well as inhibition of thromboxane…

NITROLINGUAL® Spray Rhône-Poulenc Rorer Nitroglycerin Antianginal Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demand rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation…

NITROL® Rhône-Poulenc Rorer Nitroglycerin Antianginal – Vasodilator Action And Clinical Pharmacology: The principal action of nitroglycerin is that of all nitrates, namely relaxation of vascular smooth muscle. Nitrates act primarily by reducing myocardial oxygen demands rather than increasing its oxygen supply. This effect is thought to be brought about predominantly by peripheral action. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds….

NIPRIDE® Roche Sodium Nitroprusside Antihypertensive Action And Clinical Pharmacology: Nitroprusside is a potent, rapid acting i.v. antihypertensive agent. The antihypertensive action of nitroprusside is probably due to the nitroso (NO) group. Its effect is almost immediate and usually ends when the i.v. infusion is stopped. The brief duration of the drug’s action is due to its rapid biotransformation. The hypotensive effect is augmented by ganglionic blocking agents. The hypotensive effects…

NIMOTOP® NIMOTOP® I.V. Bayer Nimodipine Adjunct in the Management of Subarachnoid Hemorrhage – Calcium Channel Blocking Agent Action And Clinical Pharmacology: Delayed neurologic deterioration secondary to cerebral ischemic deficits is believed to be a major determinant of outcome in patients who survive their initial subarachnoid hemorrhage (SAH). Nimodipine is a calcium channel blocker of the dihydropyridine group. It appears to have a more marked effect on the cerebral circulation than…