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R & C™ II Spray R & C Pyrethrins – Piperonyl Butoxide Spray Insecticide Indications And Clinical Uses: For use on lice and lice eggs on garments, bedding, mattresses and furniture. Manufacturers’ Warnings In Clinical States: Not for use on humans or animals. Precautions: Contents under pressure. Do not puncture or incinerate can. Do not use near heat or store at temperatures above 50°C. Avoid spraying in eyes. May be…

RIOPAN® RIOPAN® PLUS Whitehall-Robins Magaldrate Magaldrate – Simethicone Antacid Antacid – Antiflatulent Indications And Clinical Uses: Symptomatic relief of heartburn, indigestion and upset stomach due to excess acid, and relief of gas with Riopan Plus. Precautions: Individuals with kidney disease should not take this product except with the advice and supervision of a physician. Do not take with tetracycline antibiotics. Antacids can interfere with the absorption of iron preparations. Do…

RISPERDAL® Oral Solution RISPERDAL® Tablets Janssen-Ortho Risperidone Tartrate Risperidone Antipsychotic Agent Action And Clinical Pharmacology: Risperidone, a benzisoxazole derivative, is a novel antipsychotic drug which binds with high affinity to the serotonin type 2 (5-HT2), dopamine D2, and a1-adrenergic receptors. Risperidone binds with a lower affinity to the a2-adrenergic and histamine H1 receptors. Risperidone does not bind to dopamine D1 or muscarinic cholinergic receptors. Receptor occupancy was also demonstrated in…

RIVOTRIL® Roche Clonazepam Anticonvulsant Action And Clinical Pharmacology: Clonazepam has pharmacological properties characteristic of the benzodiazepine class of drugs. Clonazepam has sedative, hypnotic and anticonvulsant properties. As an anticonvulsant it is useful in the management of minor motor seizures (myoclonic seizures) and may be of some value in selected patients with absence spells (petit mal) who have failed to respond satisfactorily to the succinimides. Clonazepam is capable of suppressing the…

RIFATER™ Hoechst Marion Roussel Rifampin – Isoniazid – Pyrazinamide Antituberculous Antibiotic Action And Clinical Pharmacology: Rifater is an antibacterial fixed combination product containing 120 mg rifampin, 50 mg isoniazid and 300 mg pyrazinamide used for the treatment of tuberculosis. Rifampin, isoniazid and pyrazinamide are bactericidal agents active against both intracellular and extracellular tuberculosis organisms. Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase,…

RIMSO®-50 Roberts Dimethyl Sulfoxide Genitourinary Disorders Action And Clinical Pharmacology: Dimethyl sulfoxide has a wide spectrum of primary pharmacologic activity including: membrane penetrant, solute carrier across membranes, anti-inflammatory, analgesia, diuresis, cholinesterase inhibition, muscle relaxation, vasodilation, penetrant of blood-brain barrier. Although the mode of action of dimethyl sulfoxide as a treatment for various inflammatory genitourinary disorders is speculative at this time, hypotheses centre around the following: anti-inflammation, analgesic, improvement of blood…

RHINOCORT® TURBUHALER® Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The mechanism of action of…

RHINOCORT® AQUA Astra Budesonide Glucocorticosteroid Action And Clinical Pharmacology: Budesonide is a potent nonhalogenated synthetic glucocorticosteroid with strong topical and weak systemic effects. Budesonide has a high topical anti-inflammatory potency and it is rapidly biotransformed in the liver. This favorable separation between topical anti-inflammatory activity and systemic effect is due to strong glucocorticosteroid receptor affinity and an effective first pass metabolism with a short half-life. The mechanism of action of…

RIDAURA® Pharmascience Auranofin Antirheumatic Agent Action And Clinical Pharmacology: Auranofin is a gold preparation and therefore has the potential for serious gold toxicity. The mechanism by which auranofin exerts its therapeutic effect has not been established. In patients with adult rheumatoid arthritis or psoriatic arthritis, auranofin may modify disease activity as manifested by synovitis and associated symptoms, and reflected by laboratory parameters such as elevated ESR. There is no substantial…

RHEOMACRODEX® Medisan Pharmaceuticals Dextran 40 Plasma Volume Expander Action And Clinical Pharmacology: The biological properties of dextrans are functions of molecular structure, average molecular weight and molecular weight distribution. For Rheomacrodex these have been selected so that the preparation exerts both a general and a microcirculatory flow improving effect, at the same time producing a rapid increase in plasma volume. Following the infusion of Rheomacrodex, approximately 60% of the dextran…