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SULCRATE®, SULCRATE® SUSPENSION PLUS Hoechst Marion Roussel Sucralfate Gastroduodenal Cytoprotective Agent Action and Clinical Pharmacoligy: Sucralfate exerts a generalized gastric cytoprotective effect by enhancing natural mucosal defense mechanisms. Studies conducted in animals and clinical trials in humans have demonstrated that sucralfate can protect the gastric mucosa against various irritants such as alcohol, ASA, hydrochloric acid, sodium hydroxide or sodium taurocholate. In addition, sucralfate has been demonstrated to have a greater…

STRESSTABS®, STRESSTABS® PLUS, STRESSTABS® with IRON, STRESSTABS® with ZINC Whitehall-Robins Vitamin B Complex-Ascorbic Acid-Vitamin E, Vitamin B Complex-Ascorbic Acid-Vitamin E-Selenium-Zinc-Beta Carotene, Vitamin B Complex-Ascorbic Acid-Vitamin E-Iron, Vitamin B Complex-Ascorbic Acid-Vitamin E-Zinc-Copper Dietary Supplement Indications And Clinical Uses: Stresstabs: Dietary supplement in conditions responding to therapy with B complex factors. 1nbStresstabs Plus: When physiologic stress causes severe tissue depletion of the B Complex, vitamins C, A and E. Stresstabs with Iron:…

STILBESTROL Roberts Diethylstilbestrol Estrogen Action and Clinical Pharmacology: Similar to those of natural estrogens, i.e., stimulation of proliferative development of endometrium; development of secondary female sex characteristics; suppression of pituitary gonadotropin secretion; stimulation of protein synthesis; lowering of serum lipids; suppression of function of male target organs. Indications And Clinical Uses: The palliative treatment of advanced cancer of the prostate. Contra-Indications: Diethylstilbestrol should not be administered to patients with active…

STREPTASE® Hoechst Marion Roussel Streptokinase Fibrinolytic Agent Action and Clinical Pharmacology: Streptokinase acts with plasminogen (or plasmin) to produce an “activator complex” that converts residual plasminogen into the proteolytic enzyme, plasmin. Plasmin is capable of hydrolysing fibrin into polypeptides; it also hydrolyses fibrinogen and other plasma proteins. Since plasminogen is present in the thrombus/embolus, activation by streptokinase occurs within the thrombus/embolus as well as on its surface.: The activity of…

STREPTOMYCIN SULFATE™ Pfizer Aminoglycoside Antibiotic Action And Clinical Pharmacology: Streptomycin is a bactericidal antibiotic in therapeutic dosage. The mode of action is the interference with normal protein synthesis and production of “faulty proteins”. In recommended doses, Streptomycin is active against susceptible strains of many gram-negative and gram-positive organisms, and M. tuberculosis. When used alone, bacterial resistance has been shown to develop rapidly. Therefore, in the treatment of tuberculosis, it should…

STIEVA-A® Preparations, STIEVA-A® FORTE Stiefel Tretinoin Acne Therapy Availability And Storage: Cream: Each g of cream contains: tretinoin USP 0.01%, 0.025% or 0.05% in an emollient cream base. Nonmedicinal ingredients: butylated hydroxyanisole, butylated hydroxytoluene, cetyl alcohol, edetate disodium, isopropyl palmitate, methyl paraben, prolyoxyl 40 stearate, propyl paraben, propylene glycol, purified water, stearic acid, stearyl alcohol and white petrolatum. Tubes of 25 g. Forte Cream: Each g of cream contains: tretinoin…

STIEVA-A® Preparations STIEVA-A® FORTE Stiefel Tretinoin Acne Therapy Availability And Storage: Cream: Each g of cream contains: tretinoin USP 0.01%, 0.025% or 0.05% in an emollient cream base. Nonmedicinal ingredients: butylated hydroxyanisole, butylated hydroxytoluene, cetyl alcohol, edetate disodium, isopropyl palmitate, methyl paraben, prolyoxyl 40 stearate, propyl paraben, propylene glycol, purified water, stearic acid, stearyl alcohol and white petrolatum. Tubes of 25 g. Forte Cream: Each g of cream contains: tretinoin…

STIEVAMYCIN® Preparations Stiefel Erythromycin–Tretinoin Topical Acne Therapy Action and Clinical Tretinoin: The precise mechanism of action of tretinoin on the skin is not fully understood. It is known that tretinoin is both pharmacologically and structurally related to vitamin A which regulates epithelial cell growth and differentiation. Tretinoin itself is known to have an irritant and keratolytic effect on the skin. These two actions which occur simultaneously have been shown histologically…

STILAMIN® Serono Somatostatin Treatment of Acute Variceal Bleeding Action and Clinical Somatostatin is a synthetic cyclic 14 amino acid peptide (identical in structure and activity to naturally occurring somatostatin) which decreases splanchnic blood flow and portal venous pressure in man, possibly through a direct action on the unstriated muscle cells mediated by a calcium-dependent mechanism. In anesthetized healthy volunteers, somatostatin–dosed as a 250 g i.v. bolus followed by a 250…

STEMETIL® Rhône-Poulenc Rorer Prochlorperazine Antipsychotic–Antiemetic Action and Clinical Prochlorperazine is a piperazine phenothiazine derivative with antipsychotic, antiemetic and weak sedative activity. Prochlorperazine has actions similar to those of other phenothiazine derivatives but appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extrapyramidal reactions. Prochlorperazine is well absorbed from the…