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STELAZINE® SmithKline Beecham Trifluoperazine HCl Antianxiety–Antiemetic–Antipsychotic Action and Clinical The mode of action of the phenothiazines has not yet been definitely established. Existing information suggests the following possibilities: Antipsychotic/antianxiety effects: Observations suggest that the primary action is to depress the physiologic accompaniments of the emotional factors of the personality which are believed to be basically evoked by the limbic system and its connections with the hypothalamus. Experimental and clinical evidence…

STATEX® Paladin Morphine Sulfate Analgesic Availability And Storage: Drops: Each mL of clear, unflavored, colorless liquid contains: morphine sulfate 20 or 50 mg. Graduated bottles of 25 and 100 mL (20 mg/mL) and graduated bottles of 50 mL (50 mg/mL) with calibrated dropper. Suppositories: Each white, cone-shaped suppository contains: morphine sulfate 5, 10, 20 or 30 mg. Boxes of 10. The suppository should be placed against the rectal mucosa. The…

STADOL NS™ Bristol-Myers Squibb Butorphanol Tartrate Analgesic Action and Clinical Butorphanol acts as an agonist at kappa-opioid receptors and a mixed agonist-antagonist at mu-opioid receptors in the CNS to alter the perception of pain. The drug is believed to act at sites in the periventricular and periaqueductal gray matter, and at sites in the spinal cord.: In an animal model, the dose of butorphanol required to antagonize morphine analgesia by…

Composition: Isopropamide is an inherently long-acting synthetic anticholinergic agent that provides 12-hour antisecretory-antispasmodic activity. Trifluoperazine is a piperazine phenothiazine derivative with antipsychotic and antiemetic properties. The mode of action of phenothiazines has not been definitely established. Like most phenothiazines, trifluoperazine possesses weak anticholinergic and possibly alpha-adrenergic blocking activities. Indications And Clinical Uses: Stelabid may be employed to advantage in the treatment of a wide range of gastrointestinal disorders, including such…

STATICIN® Westwood-Squibb Erythromycin–Ethyl Alcohol–Laureth-4 Acne Therapy Indications And Clinical Uses: The treatment of acne vulgaris. For use primarily in the treatment of the inflammatory papular lesions of acne. Contra-Indications: Hypersensitivity to any of the components. Warnings in Clinical States: Eye contact should be avoided since Staticin is irritating to the eyes. Instillation in the rabbit eye is known to provoke corneal damage. Concomitant topical antiacne therapy should be avoided because…

SSD™ Knoll Silver Sulfadiazine Topical Antibacterial Action and Clinical The mechanism of silver sulfadiazine’s antimicrobial action has not been fully elucidated. The dominant manifestation of the reaction of silver sulfadiazine with sensitive organisms may result from the displacement of hydrogen bonds within the bacterial DNA. Once these bonds that serve to connect the 2 strands of the DNA double helix are displaced, bacterial replication and cell viability are effectively reduced….

SPECTRO TAR™ Antiseptic Shampoo Spectropharm Dermatology Chlorhexidine Gluconate–Coal Tar Psoriasis–Seborrhea Therapy Availability And Storage: Each mL of foaming shampoo, stainless and virtually devoid of tar odor after rinsing, contains: chlorhexidine gluconate 1% w/v, and a special solution of coal tar 7.5% w/v in a soapless, biodegradable vehicle. Plastic bottles of 200 mL. SPECTRO TAR™ Antiseptic Shampoo Spectropharm Dermatology Chlorhexidine Gluconate–Coal Tar Psoriasis–Seborrhea Therapy

SPORANOX® Capsules Janssen-Ortho Itraconazole Antifungal In vitro studies have demonstrated that itraconazole inhibits the cytochrome P450-dependent synthesis of ergosterol which is a vital component of fungal and yeast cell membranes. This inhibition leads to deteriorated membranes, disturbed enzyme activities and an uncoordinated synthesis of chitin, all together contributing to the antifungal activity. The inhibition of ergosterol synthesis has been attributed to interference with the reactions involved in the removal of…

SPOREX® Rougier Pharma Formaldehyde Solution for Cold Sterilization Availability And Storage: Each mL of pale yellow clear liquid with latent formaldehyde odor contains: formaldehyde 10%, benzalkonium chloride 0.1% and sodium nitrite (anti-rust) 1%. Bottles of 5 L. SPOREX® Rougier Pharma Formaldehyde Solution for Cold Sterilization

SPORANOX® Oral Solution Janssen-Ortho Itraconazole Antifungal Action and Clinical Mode of Action: Itraconazole, a triazole derivative, has a broad-spectrum activity; with respect to Candida spp., its activity includes C. albicans, C. glabrata and C. krusei. In vitro studies have demonstrated that itraconazole impairs the synthesis of ergosterol in fungal cells. Ergosterol is a vital cell membrane component in fungi. Impairment of its synthesis ultimately results in an antifungal effect. Pharmacokinetics:…