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ACEL-P™ Wyeth-Ayerst Acellular Pertussis Vaccine Adsorbed Active Immunizing Agent Action And Clinical Pharmacology: Pertussis disease (whooping cough) is caused by a gram-negative coccobacillus, B. pertussis. Acellular pertussis vaccine adsorbed is an acellular pertussis vaccine indicated for primary immunization against disease caused by B. pertussis. Pertussis (whooping cough) has 3 typical stages (catarrhal, paroxysmal, and convalescent). The second phase is characterized by severe paroxysmal coughing that persists for weeks. The disease…

  ACNOMEL® Chattem Resorcinol – Sulfur Compound Acne Therapy Indications And Clinical Uses: Treatment of acne: basic topical medication for acne. The tinted cream may be used by patients who desire a medicated preparation to mask lesions. Contra-Indications: Should not be applied to diffuse, acutely inflamed areas. Keep out of eyes and off eyelids. Precautions: Moderate erythema and scaling are normal and expected results of therapy. However, should these reactions…

ACNOMEL® Acne Mask Chattem Salicylic Acid Acne Therapy Indications And Clinical Uses: For treatment of acne. Precautions: Avoid contact with eyes. Dosage: Splash face with warm water. Apply the acne mask over entire face, avoiding eyes. Leave on as a mask for 10 minutes. Rinse off with warm water. Use once or twice weekly. Availability And Storage: Each mL contains: salicylic acid 1.5% in cream base with 100% natural clays….

Act-HIB® Connaught Haemophilus b Conjugate Vaccine (Tetanus Protein – Conjugate) Active Immunizing Agent Action And Clinical Pharmacology: Clinical Data (PRP-T): Haemophilus b Conjugate Vaccine has been administered during clinical trials to over 110 000 infants and children in Canada, the U.S., Finland, France, Chile, Israel, and the United Kingdom using local immunization schedules, and has been used widely in immunization programmes. In clinical trials where 921 infants were given the…

ACCUPRIL™ Parke-Davis Quinapril HCl Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Quinapril is a nonpeptide, nonsulphydryl inhibitor of angiotensin converting enzyme (ACE), which is used in the treatment of hypertension. Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor angiotensin II. After absorption, quinapril is rapidly de-esterified to quinaprilat (quinapril diacid), its principal active metabolite. Its primary mode of action…

ACCURETIC™ Parke-Davis Quinapril HCl – Hydrochlorothiazide Angiotensin-Converting Enzyme Inhibitor – Diuretic Action And Clinical Pharmacology: Accuretic is a fixed-combination tablet which combines the antihypertensive actions of an angiotensin-converting enzyme (ACE) inhibitor, quinapril HCl, and a diuretic, hydrochlorothiazide. In clinical studies, administration of this combination produced greater reductions in blood pressure than the single agents given alone. Pharmacokinetics and Metabolism: Quinapril: Following oral administration of quinapril, peak plasma concentrations of quinapril…

ACCUTANE™ ROCHE® Roche Isotretinoin Acne Therapy Action And Clinical Pharmacology: The mechanism of action of isotretinoin is unknown. Vitamin A is important for functional integrity of the skin and is known to affect the keratinization process. In acne patients, improvement occurs in association with a reduction in sebum secretion. The decrease in sebum secretion is temporary and is related to either the dose or duration of isotretinoin administration and reflects…

ACE INHIBITORS General Monograph, Benazepril Captopril Cilazapril Enalapril Enalaprilat Fosinopril Lisinopril Perindopril Quinapril Ramipril Trandolapril Angiotensin Converting Enzyme Inhibitor, Action And Clinical Pharmacology: The renin-angiotensin system is a complex neuroendocrine system involved in the regulation of hemodynamics and water and electrolyte balance. When released from the kidney in response to a decrease in blood volume, renal perfusion pressure or plasma sodium concentration, renin acts on its substrate, angiotensinogen, to form…

ABBOKINASE® OPEN-CATH® Abbott Urokinase Fibrinolytic Action And Clinical Pharmacology: Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen. When used as directed for i.v. catheter clearance only small amounts of urokinase may reach the circulation; therefore, therapeutic serum levels are not expected to be achieved. Nevertheless, one should be aware of the clinical pharmacology of urokinase. I.V….

ABBOKINASE® Abbott Urokinase Fibrinolytic Action And Clinical Pharmacology: Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen. I.V. infusion of urokinase in doses recommended for lysis of pulmonary embolism is followed by increased fibrinolytic activity. This effect disappears within a few hours after discontinuation, but a decrease in plasma levels of fibrinogen and plasminogen and an increase…