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ADVIL® Whitehall-Robins Ibuprofen Analgesic – Antipyretic Indications And Clinical Uses: Adults and Children over 12: For fast and effective relief of headaches, toothache and menstrual pain, and for minor aches and pain associated with arthritis, muscles, joints and backache, and for reduction of fever. Children 12 and under: For fever and pain due to colds, sore throat, immunizatin and earache. Contra-Indications: Hypersensitivity to ibuprofen. Patients with active peptic ulcers or…

ADVIL® COLD & SINUS Whitehall-Robins Ibuprofen – Pseudoephedrine HCl Analgesic – Antipyretic – Decongestant Action And Clinical Pharmacology: Ibuprofen has exhibited analgesic and antipyretic activity in animal studies designed to specifically demonstrate these effects. Ibuprofen has been shown to have no glucocorticoid-like activity. Pseudoephedrine is an orally effective nasal decongestant when administered in doses of 60 mg/dose, up to 240 mg/day. In order to comply with the flexible dosing schedule…

ADENOCARD® Fujisawa Adenosine Antiarrhythmic Action And Clinical Pharmacology: Adenosine is an endogenous nucleoside occurring in all cells of the body. When injected i.v. adenosine slows atrioventricular (AV) nodal conduction, can interrupt the reentry pathways through the AV node and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White syndrome. Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline and potentiated…

ADRIAMYCIN® Pharmacia & Upjohn Doxorubicin HCl Antineoplastic Agent Action And Clinical Pharmacology: Though not completely elucidated, the mechanism of action of doxorubicin is related to its ability to bind to DNA and inhibit nucleic acid synthesis. Cell culture studies have demonstrated rapid cell penetration and perinucleolar chromatin binding, rapid inhibition of mitotic activity and nucleic acid synthesis, mutagenesis and chromosomal aberrations. Animal studies have shown activity in a wide spectrum…

ADRUCIL® Pharmacia & Upjohn Fluorouracil Antineoplastic Action And Clinical Pharmacology: The mechanism of action of fluorouracil is mainly related to competitive inhibition of thymidylate synthetase, the enzyme catalyzing the methylation of deoxyuridylic acid to thymidylic acid. The consequent thymidine deficiency results in inhibition of deoxyribonucleic acid (DNA) synthesis, thus inducing cell death. Also, moderate inhibition of ribonucleic acid (RNA) and incorporation of fluorouracil into RNA have been observed. The predominant…

ACTIFED® Warner-Lambert Consumer Healthcare Triprolidine HCl – Pseudoephedrine HCl Antihistaminic – Decongestant Indications And Clinical Uses: The prophylaxis and treatment of symptoms associated with the common cold, acute and subacute sinusitis, acute eustachian salpingitis, serous otitis media with eustachian tube congestion, aerotitis media and croup; in allergic conditions which respond to antihistamines, including hay fever, pollenosis, allergic and vasomotor rhinitis. Contra-Indications: Hypersensitivity to triprolidine or pseudoephedrine. Should not be administered…

ACTIFED™ PLUS EXTRA STRENGTH Warner-Lambert Consumer Healthcare Acetaminophen – Pseudoephedrine HCl – Triprolidine HCl Analgesic – Antipyretic – Antihistamine – Decongestant Indications And Clinical Uses: The prophylaxis and treatment of symptoms associated with the common cold, acute and subacute sinusitis; in allergic conditions which respond to antihistamines, including hay fever, pollenosis, allergic and vasomotor rhinitis. Relieves nasal congestion, runny nose, sneezing, sinus pain, headache and fever. Contra-Indications: Hypersensitivity to triprolidine,…

ACTINAC® Hoechst Marion Roussel Chloramphenicol – Hydrocortisone Acetate – Butoxyethylnicotinate – Allantoin – Precipitated Sulfur Acne Therapy Action And Clinical Pharmacology: The roles of the individual ingredients in Actinac and their collective mechanisms of action in the topical treatment of acne have not been elucidated. Hydrocortisone, chloramphenicol and precipitated sulfur are however, widely recognized for their respective anti-inflammatory, antibacterial and desquamating properties. Chloramphenicol is usually bacteriostatic in action, but may…

ACULAR® Allergan Ketorolac Tromethamine Topical Anti-inflammatory Action And Clinical Pharmacology: Ketorolac is a nonsteroidal, anti-inflammatory agent demonstrating analgesic and anti-inflammatory activity. At concentrations of 0.02 to 0.5%, ketorolac solution did not irritate the eyes of rats, dogs and monkeys. Up to 4% concentrations were nonirritating in albino rabbits. Ketorolac has demonstrated anti-inflammatory activity when applied topically in several animal models of ocular inflammation. The compound significantly inhibited the inflammatory response…

ACYCLOVIR SODIUM FOR INJECTION Novopharm Antiviral Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster-specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster-specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate….