You searched for : 'K'

TAZOCIN® Wyeth-Ayerst Piperacillin Sodium–Tazobactam Sodium Antibiotic–b-lactamase Inhibitor Action and Clinical Tazocin is an injectable antibacterial combination consisting of the semisynthetic antibiotic piperacillin sodium and the b-lactamase inhibitor tazobactam sodium for i.v. administration. Piperacillin exerts bactericidal activity by inhibiting septum formation and cell wall synthesis. In vitro, piperacillin is active against a variety of gram-positive and gram-negative aerobic and anaerobic bacteria. Tazobactam is a b-lactamase inhibitor. Tazobactam, in combination with piperacillin…

TAZORAC™ Allergan Tazarotene Antipsoriasis Antiacne Action and Clinical Tazarotene is a retinoid prodrug which is converted to its active form, M1 (“tazarotenic acid”, or AGN 190299), by rapid de-esterification in most biological systems. “Tazarotenic acid” binds to and regulates gene expression through all three members of the RAR family of retinoid nuclear receptors, RAR a, RAR b, and RAR g, but shows selectivity for RAR b and RAR g.: Psoriasis:…

Td POLIO ADSORBED (Tetanus and Diphtheria Toxoids Adsorbed and Inactivated Poliomyelitis Vaccine) Connaught Active Immunizing Agent Action and Clinical Pharmacology Tetanus is an acute and often fatal disease caused by an extremely potent neurotoxin produced by C. tetani. The organism is ubiquitous and its occurrence in nature cannot be controlled. Immunization is highly effective, produces long-lasting protection and is recommended for the whole population. Only 2 to 3 cases of…

TARO-DESOXIMETASONE Taro Desoximetasone Topical Corticosteroid Action and Clinical Pharmacology: Desoximetasone cream is a potent fluorinated corticosteroid. Topical corticosteroids are synthetic derivatives of cortisone which are effective when applied locally to control many types of inflammatory, allergic and pruritic dermatoses. Modifications to the chemical structure, such as fluorination, generally enhance both anti-inflammatory activity and increase the likelihood of adverse effects. The mechanism of anti-inflammatory activity of topical corticosteroids is generally unclear….

TASMAR™ Roche Tolcapone Antiparkinsonian – COMT-inhibitor Action And Clinical Pharmacology: Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated…

TAXOL™ Bristol-Myers Squibb Paclitaxel Antineoplastic Agent Caution: Paclitaxel should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel should be pretreated with corticosteroids, antihistamines, and H 2 antagonists (such as dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). Severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in patients…

TARO-CARBAMAZEPINE Anticonvulsant-Symptomatic Relief of Trigeminal Neuralgia-Antimanic Action and Clinical Pharmacology Carbamazepine has anticonvulsant properties which have been found useful in the treatment of partial seizures (simple or complex) with and without secondary generalization, and generalized tonic-clonic seizures. A mild psychotropic effect has been observed in some patients, which seems related to the effect of carbamazepine in localization-related epilepsies and syndromes.: Clinical Trials: Evidence supporting the efficacy of carbamazepine as an…

TAMOFEN® Rh´ne-Poulenc Rorer Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to is ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In…

TAMONE® Pharmacia & Upjohn Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to its ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA), and causes the regression of already established DMBA-induced tumors….

TANACET 125® Ashbury Biologicals/Herbal Laboratories Standardized Feverfew Migraine Prophylaxis Action And Clinical Pharmacology: Clinical trials conducted in the United Kingdom have established the effectiveness of feverfew (Tanacetum parthenium) when taken daily over a 2-month period in reducing the frequency and intensity of migraine attacks. Tanacet 125 contains specially prepared and standardized feverfew leaf (Tanacetum parthenium) which is a recognized traditional herbal remedy for several conditions, including the prevention of migraine…