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  ANTIPHLOGISTINE RUB A-535 Carter Horner Methyl Salicylate – Camphor – Menthol – Eucalyptus Oil Topical Analgesic Indications And Clinical Uses: External counterirritant cream for temporary pain relief of stiff and sore muscles, backache, strains, arthritic and rheumatic pain, sciatica, lumbago and bursitis. Contra-Indications: Salicylate hypersensitivity. Precautions: For external use only. Do not apply to wounds or damaged skin and avoid contact with eyes and mucous membranes. Discontinue use if…

Antivenin (Latrodectus Mactans) MSD Black Widow Spider Antivenin Indications And Clinical Uses: Used to treat patients suffering from symptoms due to bites from the black widow spider. Early use of the antivenin is emphasized for prompt relief. Manufacturers’ Warnings In Clinical States: Prior to treatment with any product prepared from horse serum, a careful review of the patient’s history should be taken emphasizing prior exposure to horse serum or any…

ANTIVERT™ Pfizer Meclizine HCl – Nicotinic Acid Vertigo Therapy Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. Nicotinic acid is a vasodilator agent which has been found effective in the treatment of vertigo due to cerebral arteriosclerosis. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine…

ANTURAN® Novartis Pharmaceuticals Sulfinpyrazone Platelet Inhibitory Agent – Uricosuric Agent – Prophylactic Agent for Reduction of Mortality Post-myocardial Infarction Action And Clinical Pharmacology: Sulfinpyrazone inhibits thrombotic processes that are associated with platelet adhesion, aggregation and reduced platelet survival. Sulfinpyrazone reduces serum urate levels, prevents formation of new tophi, and promotes resorption of existing tophi by increasing clearance of uric acid and water through the kidneys. Sulfinpyrazone has been shown to…

ANSAID® Pharmacia & Upjohn Flurbiprofen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Flurbiprofen, a phenylalkanoic acid derivative, is a nonsteroidal anti-inflammatory agent which also possesses analgesic and antipyretic activities. Its mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. However, its therapeutic action is not due to pituitary-adrenal stimulation. Flurbiprofen is an inhibitor of prostaglandin synthesis. The resulting decrease in prostaglandin synthesis may partially explain the…

ANTABUSE® Wyeth-Ayerst Disulfiram Alcohol Deterrent Action And Clinical Pharmacology: Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism after disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of…

ANDROCUR® ANDROCUR® DEPOT Berlex Canada Cyproterone Acetate Antiandrogen Action And Clinical Pharmacology: Cyproterone is a steroid which clinically demonstrates 2 distinct properties: Antiandrogenic: Cyproterone blocks the binding of dihydrotestosterone – the active metabolite of testosterone – to the specific receptors in the prostatic carcinoma cell. Progestogenic/antigonadotrophic: Cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of LH leading to diminished production of testicular testosterone. The absorption…

ANDRIOL Organon Testosterone Undecanoate Androgen Action And Clinical Pharmacology: Testosterone undecanoate, an orally active testosterone preparation, is a fatty acid ester of the natural androgen testosterone. Unlike other oral testosterone preparations, testosterone undecanoate is able to by-pass the liver via the lymphatic system and is therefore orally bioavailable. Therapy with Andriol increases plasma levels of testosterone and its active metabolites, leading to a regular therapeutic effect. In eugonadal men, peak…

ANECTINE® Glaxo Wellcome Succinylcholine Chloride Neuromuscular Blocking Agent Action And Clinical Pharmacology: Succinylcholine is an ultra short-acting depolarizing-type, skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Onset of flaccid paralysis is rapid, (less than…

ANEXATE® Roche Flumazenil Benzodiazepine Antagonist Action And Clinical Pharmacology: Flumazenil, an imidazobenzodiazepine, is a benzodiazepine antagonist which blocks the central effects of agents that act via the benzodiazepine receptor, by competitive inhibition. The antagonism is specific, since in animal experiments the effects of compounds which have no affinity for the benzodiazepine receptor (e.g., barbiturates, meprobamate, ethanol, GABA-mimetics, and adenosine receptor agonists) were not affected by flumazenil. Following the i.v. administration…