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ANACIN® ANACIN® EXTRA STRENGTH Whitehall-Robins ASA – Caffeine Analgesic – Antipyretic – Anti-inflammatory Indications And Clinical Uses: For fast relief of headaches, aches and fever of colds, arthritic and rheumatic pain, toothache and menstrual pain. Contra-Indications: Sensitivity to salicylates, bleeding ulcers and patients with blood coagulation defects, hemophilia, anemia, vitamin K deficiency, renal function impairment, asthma, sensitivity to caffeine and cardiac disease. Manufacturers’ Warnings In Clinical States: All salicylates should…

ANALGESIC BALM Warner-Lambert Consumer Healthcare Menthol – Methyl Salicylate Topical Analgesic Indications And Clinical Uses: For the local treatment of muscular and joint pains. Contra-Indications: Any sensitivity to the components. Precautions: Avoid contact with eyes, mucous membranes or broken skin. Keep out of reach of children. In case of accidental swallowing, seek medical advice. Dosage: Apply by thoroughly rubbing into the skin to promote absorption. To prolong the effect, cover…

ANAFRANIL® Novartis Pharmaceuticals Clomipramine HCl Antidepressant – Antiobsessional Action And Clinical Pharmacology: Clomipramine is a tricyclic agent with both antidepressant and antiobsessional properties. Like other tricyclics, clomipramine inhibits norepinephrine and serotonin uptake into central nerve terminals, possibly by blocking the membrane-pump of neurons, thereby increasing the concentration of transmitter monoamines at receptor sites. Clomipramine is presumed to influence depression and obsessive and compulsive behavior through its effects on serotonergic neurotransmission….

AMOXICILLIN Amoxycillin Antibiotic Pharmacology: Amoxicillin, a semisynthetic penicillin of the aminopenicillin group, is bactericidal against sensitive organisms. It acts through the inhibition of mucopeptide synthesis in the bacterial cell wall. The spectrum of activity of amoxicillin includes H. influenzae, E. coli, P. mirabilis, Salmonella and some Shigella species while also retaining activity against penicillin-sensitive gram-positive bacteria (see Penicillin G/Penicillin V, General Monograph). However, many Enterobacteriaceae, H. Influenzae, Salmonella and Shigella…

AMPICIN® Bristol Ampicillin Sodium Antibiotic Action And Clinical Pharmacology: Ampicillin is a broad-spectrum penicillin, indicated for the treatment of a wide range of bacterial infections caused by ampicillin-sensitive organisms. Ampicillin is similar to benzyl penicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of cell wall mucopeptide biosynthesis. Ampicillin has a broad spectrum of bactericidal activity against many gram-positive and…

ANA-KIT® Bayer Epinephrine – Chlorpheniramine Maleate Allergy Therapy Action And Clinical Pharmacology: Epinephrine: The most valuable drug for the emergency treatment of severe allergic reactions is epinephrine. The vasoconstrictor effect of epinephrine on the capillary directly antagonizes the generalized vasodilation produced by histamine. Epinephrine reverses the increased permeability of dilated capillaries to plasma. The shock of severe allergic reactions is due to the loss of circulating blood volume by pooling…

AMSA P-D™ Parke-Davis Amsacrine Antineoplastic Action And Clinical Pharmacology: Amsacrine is a potent cytotoxic agent. In in vitro studies, the LD50 against cultured L1210 cells is 0.04 µg/mL and 0.2 µg/mL against cultured Novikoff cells at 6 hours. Higher concentrations or longer exposure produce cell destruction. A 3 hour exposure of Novikoff cells to 2 µg of AMSA P-D indicated 62% inhibition of DNA synthesis (incorporation of radioactive thymidine) while…

AMINO-CERV Milex Amino Acids – Sodium Propionate – Urea Cervical Therapy Action And Clinical Pharmacology: Methionine and cystine are amino-acids necessary for wound healing and forming of epithelial tissue. Inositol acts as an essential growth factor and promotes epithelialization. Urea aids in debridement, dissolves the coagulum and promotes epithelialization. Its solvent action on fibroblasts prevents the formation of excessive tissue, thus preventing stenosis when used as directed. Benzalkonium chloride serves…

AMINOHIPPURATE SODIUM MSD Determination of Renal Function Action And Clinical Pharmacology: Aminohippurate Sodium (PAH) is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1 to 2 mg/100 mL), an average of 90% of PAH is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance,…

AMITRIPTYLINE Antidepressant Pharmacology: Amitriptyline is a tertiary amine tricyclic antidepressant. The manner in which the tricyclic antidepressants exert their clinical antidepressant effect is uncertain but they have been shown to block, in different degrees, the reuptake of various neurotransmitters including serotonin and norepinephrine at the neuronal membrane. This action potentiates the effects of these neurotransmitters. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and…