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CERVIDIL™ Ferring Dinoprostone Prostaglandin Action And Clinical Pharmacology: Dinoprostone (PGE2) is a naturally occurring biomolecule. It is found in low concentrations in most tissues of the body and functions as a local hormone. As with any local hormone, it is very rapidly metabolized in the tissues of synthesis. The rate limiting step for inactivation is regulated by the enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH). Any PGE2 that escapes local inactivation is rapidly…

CERUMOL® Solvay Pharma Paradichlorobenzene – Chlorbutol – Oil of terebinth Cerumenolytic Indications And Clinical Uses: Removal of cerumen from the external auditory meatus. Contra-Indications: Perforated ear drum, otitis externa, seborrheic dermatitis or eczema affecting the external ear. Hypersensitivity to any of the components. Precautions: Cerumol contains peanut oil, and although there have been no reports of any reaction, patients allergic to peanuts should use Cerumol only under the advice of…

CESAMET® Lilly Nabilone Antiemetic Action And Clinical Pharmacology: Nabilone is a synthetic cannabinoid with antiemetic properties which have been found to be of value in the management of some patients with nausea and vomiting associated with cancer chemotherapy. It also has sedative and psychotropic effects. After oral administration, comparable peak plasma levels of nabilone and of its carbinol metabolite were attained within 2 hours. The combined plasma concentrations of nabilone…

CHERACOL® Roberts Codeine Phosphate – Guaifenesin – Ammonium Chloride Antitussive – Expectorant Indications And Clinical Uses: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum which does not respond to products of lesser potency. Contraindications Contraindications and Precautions: In patients with asthma or pulmonary emphysema, indiscriminate use may precipitate respiratory insufficiency resulting from increased viscosity of bronchial secretions and suppression of the cough reflex. Use with…

CEPTAZ® Glaxo Wellcome Ceftazidime Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftazidime, a semisynthetic cephalosporin antibiotic, results from inhibition of bacterial cell wall synthesis. Ceftazidime has a high affinity for the Penicillin-Binding Protein-3 (PBP-3) and moderate affinity for the PBP-1a of certain gram negative organisms such as E. coli and P. aeruginosa. The affinity for PBP-1b is much less than that for either…

CEREBYX® Parke-Davis Fosphenytoin Sodium Antiepileptic Action And Clinical Pharmacology: Introduction: Following parenteral administration of fosphenytoin, fosphenytoin is converted to the anticonvulsant phenytoin. For every mmol of fosphenytoin administered, 1 mmol of phenytoin is produced. The pharmacological and toxicological effects of fosphenytoin include those of phenytoin. However, the hydrolysis of fosphenytoin to phenytoin yields 2 metabolites, phosphate and formaldehyde. Formaldehyde is subsequently converted to formate, which is in turn metabolized via…

CERUBIDINE® Rh´ne-Poulenc Rorer Daunorubicin Antimitotic – Antibiotic Action And Clinical Pharmacology: Daunorubicin inhibits the synthesis of nucleic acids; its effect on desoxyribonucleic acid is particularly rapid and marked. Ribonucleic acid is more gradually affected. It appears that the action of the drug is the result of the formation of a complex with desoxyribonucleic acid in the cell nucleus; this blocks the site of action of the polymerases and gives daunorubicin…

CERUMENEX® Purdue Frederick Triethanolamine Polypeptide Oleate-condensate Cerumenolytic Indications And Clinical Uses: For removal of impacted cerumen. Cleansing prior to aural examination, treatment, or audiometry. Should not be used for routine wax removal or cleaning of the ears. Contra-Indications: Perforated eardrum. Middle ear infection or severe inflammatory or atopic dermatitis in the external ear. Positive patch test. History of untoward reaction to Cerumenex. Precautions: Should be used with extreme caution in…

CELESTONE® SOLUSPAN ® Schering Betamethasone Sodium Phosphate – Betamethasone Acetate Injectable Glucocorticoid Indications And Clinical Uses: (1) I.M. injection in allergic, dermatologic, rheumatic, and other conditions responsive to systemic corticosteroids, including bursitis; (2) injection directly into the affected tissues in bursitis and associated inflammatory disorders of tendons such as tenosynovitis, and inflammatory disorders of muscle such as fibrositis and myositis; (3) intra-articular and periarticular injection in rheumatoid arthritis and osteoarthritis;…

CellCept® Roche Mycophenolate Mofetil Immunosuppressant Agent Manufacturers’ Warnings In Clinical States: Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. Only physicians experienced in immunosuppressive therapy and management of solid organ transplant patients should use mycophenolate mofetil. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete…