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CHOLOXIN® Knoll hyper Hypolipidemic Thyroactive Agent Action And Clinical Pharmacology: Dextrothyroxine reduces serum cholesterol levels in hyperlipidemic patients. Beta lipoprotein and triglyceride fractions may also be reduced from previously elevated levels. Dextrothyroxine stimulates the liver to increase catabolism and excretion of cholesterol and its degradation products via the biliary route into the feces. Cholesterol synthesis is not inhibited and abnormal metabolic end-products do not accumulate in the blood. Indications And…

CHLORPROMAZINE General Monograph, Antipsychotic – Antiemetic Pharmacology: Chlorpromazine is an aliphatic phenothiazine. Phenothiazines are thought to elicit their antipsychotic and antiemetic effects via interference with central dopaminergic pathways in the mesolimbic and medullary chemoreceptor trigger zone areas of the brain, respectively. Extrapyramidal side effects are a result of interaction with dopaminergic pathways in the basal ganglia. Although often termed dopamine blockers, the exact mechanism of dopaminergic interference responsible for the…

CHOLEDYL® EXPECTORANT Parke-Davis Oxtriphylline – Guaifenesin Bronchodilator – Expectorant Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. tag_IndicationsIndications Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with chronic obstructive pulmonary emphysema, bronchial asthma, chronic bronchitis and related bronchospastic disorders and where expectoration is required. Precautions: Patients starting therapy should be carefully observed to determine if this fixed dose combination is…

CHOLEDYL® Parke-Davis Oxtriphylline Bronchodilator Action And Clinical Pharmacology: Oxtriphylline contains 64% theophylline and has the properties attributed to theophylline. Indications And Clinical Uses: The symptomatic treatment of reversible bronchoconstriction associated with bronchial asthma, chronic obstructive pulmonary emphysema, chronic bronchitis and related bronchospastic disorders. Contra-Indications: Hypersensitivity to xanthines; active peptic ulcer; in coronary artery disease when myocardial stimulation might prove harmful. Precautions: Parents should be cautioned against overdosage to children –…

CHLORAMPHENICOL General Monograph, Antibiotic Pharmacology: Chloramphenicol, which was originally isolated from Streptomyces venezuelae and is now synthetically produced, exerts mainly a bacteriostatic effect on a wide range of gram-positive and gram-negative organisms and is active against Rickettsia, Chlamydia (psittacosis-lymphogranuloma organisms), and Mycoplasma. It is particularly effective against H. influenzae, S. pneumoniae, S. typhi and Neisseria species. The palmitate and sodium succinate esters are inactive until hydrolyzed to free chloramphenicol which…

CHLORAL HYDRATE General Monograph, Sedative – Hypnotic Pharmacology: Chloral hydrate has general CNS depressant effects believed to be due to its active metabolite, trichloroethanol. In doses used for hypnosis, chloral hydrate produces mild cerebral depression and quiet, deep sleep, usually with little or no hangover effects. Chloral hydrate decreases sleep latency and nighttime awakenings with minimal effects on REM sleep. REM rebound does not occur with drug withdrawal. Tolerance to…

CHLOROMYCETIN® INJECTION Parke-Davis Chloramphenicol Antibiotic Indications And Clinical Uses: In accordance with the concepts in the Contraindications section and this Indications section, chloramphenicol should be used only in those conditions for which it may be the antibiotic of choice. These would include: Acute infections caused by Salmonella typhi. It is not recommended for the routine treatment of the typhoid carrier state. Serious infections caused by susceptible strains: (a) Salmonella species…

CHLOR-TRIPOLON® Schering Chlorpheniramine Maleate Antihistamine Indications And Clinical Uses: The symptomatic relief of allergic states generally responsive to antihistamines, such as hay fever, urticaria, angioedema, vasomotor rhinitis, allergic eczema, serum sickness and drug reactions; also in allergic conjunctivitis, dermographism, gastrointestinal allergy, physical allergy, and exanthematous eruptions such as measles and chickenpox. Useful in atopic dermatitis, contact dermatoses (including poisoning by ivy or oak), insect bites, neurodermatitis, pruritus ani and vulvae…

CHLOR-TRIPOLON® DECONGESTANT CHLOR-TRIPOLON® DECONGESTANT Syrup CHLOR-TRIPOLON® DECONGESTANT Tablets Schering Chlorpheniramine Maleate – Phenylpropanolamine HCl Chlorpheniramine Maleate – Pseudoephedrine Sulfate Antihistamine – Decongestant Indications And Clinical Uses: Symptomatic relief of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis and rhinosinusitis, acute and subacute sinusitis, eustachian tube blockage and secretory otitis media. Contra-Indications: Patients receiving or having received MAO inhibitors in the preceding 2 weeks; known hypersensitivity to…

CHLOR-TRIPOLON N.D.® Schering Loratadine – Pseudoephedrine Sulfate Histamine H1-Receptor Antagonist – Sympathomimetic Amine Action And Clinical Pharmacology: Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1 receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at 2 hours and persists throughout the 24 hour observation period. Single oral doses up to 160 mg…