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EFFEXOR® EFFEXOR® XR Wyeth-Ayerst Venlafaxine HCl Antidepressant Action And Clinical Pharmacology: Venlafaxine is a phenethylamine bicyclic derivative, chemically unrelated to tricyclic, tetracyclic or other available antidepressant agents. The mechanism of venlafaxine’s antidepressant action in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Preclinical studies have shown that venlafaxine and its major metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake…

EDECRIN® SODIUM EDECRIN® MSD Ethacrynic Acid Ethacrynate Sodium Diuretic – Saluretic Action And Clinical Pharmacology: Ethacrynic acid is a saluretic-diuretic agent with marked potency and rapid onset of action. It is chemically unrelated to other diuretics. Patients with congestive heart failure (including acute pulmonary edema), renal edema, hepatic cirrhosis with ascites, and other conditions involving fluid retention have responded well to ethacrynic acid. Ethacrynic acid has the following major characteristics:…

DRISTAN® N.D. DRISTAN® N.D. EXTRA STRENGTH Whitehall-Robins Acetaminophen – Pseudoephedrine HCl Analgesic – Decongestant Indications And Clinical Uses: For the symptomatic relief of colds, sinusitis, nasal congestion, sneezing, runny nose, fever, headache, minor aches and pains. Contra-Indications: Hypersensitivity to any of the components. Patients receiving MAO inhibitors. Precautions: Use with caution on elderly patients or those with hypertension, diabetes, glaucoma, coronary artery disease, hyperthyroidism, prostatic hypertrophy and patients receiving MAO…

ECHOVIST® Berlex Canada Galactose Ultrasound Contrast Agent Action And Clinical Pharmacology: Echovist is an ultrasound contrast agent consisting of a suspension of micron-sized air bubbles, formed upon reconstitution of specially formulated galactose granules with an aqueous galactose solution. Following intrauterine administration of the suspension, the bubbles serve to enhance ultrasound signals from the uterine cavity and fallopian tubes, thus enabling better visualization of these structures. Upon completion of the ultrasound…

ECOSTATIN® Preparations Westwood-Squibb Econazole Nitrate Antifungal Agent Action And Clinical Pharmacology: Econazole exhibits antifungal activity against a wide variety of fungi, including dermatophytes, pathogenic yeasts, and moulds. Susceptible pathogenic organisms include C. albicans and other Candida species, T. rubrum, T. mentagrophytes, E. floccosum and M. furfur. It appears to act by altering the internal structure or cell membrane permeability of the fungus. tag_IndicationsIndications Indications And Clinical Uses: Cream: The treatment…

DRISTAN® DRISTAN® EXTRA STRENGTH Whitehall-Robins Phenylephrine – Chlorpheniramine – Acetaminophen Decongestant – Antihistamine – Analgesic Indications And Clinical Uses: For the symptomatic relief of colds, sinusitis, hay fever or other upper respiratory allergies, nasal congestion, sneezing, runny nose, fever, headache, minor aches and pains. Contra-Indications: Hypersensitivity to any of the components. Patients receiving MAO inhibitors. Precautions: Use with caution on elderly patients or patients with allergy to acetaminophen, chronic alcoholism,…

DPE™ Alcon Dipivefrin HCl Glaucoma Therapy Action And Clinical Pharmacology: Dipivefrin is converted to epinephrine inside the human eye by enzyme hydrolysis. The liberated epinephrine, an adrenergic agonist, appears to exert its action by decreasing aqueous production and by enhancing outflow facility. The dipivefrin hydrochloride prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine…

DRISTAN® LONG LASTING NASAL MIST/SPRAY Whitehall-Robins Oxymetazoline HCl Nasal Decongestant Action And Clinical Pharmacology: The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Indications And Clinical Uses: For prompt temporary relief of nasal congestion due to the common cold, sinusitis, hay fever or other upper respiratory allergies for up to 12 hours. Contra-Indications: Narrow angle…

DRISTAN® NASAL MIST/SPRAY Whitehall-Robins Pheniramine – Phenylephrine Nasal Decongestant Action And Clinical Pharmacology: Phenylephrine is a sympathomimetic agent that constricts the smaller arterioles of the nasal passages producing a gentle and predictable decongesting effect. Pheniramine is an antihistamine that controls rhinorrhea, sneezing and lacrimation associated with elevated histamine levels in disorders of the respiratory tract. Indications And Clinical Uses: Prompt temporary relief of nasal congestion due to colds, sinusitis, hay…

DOVONEX® Leo Calcipotriol Topical Nonsteroidal Antipsoriatic Action And Clinical Pharmacology: Calcipotriol is a nonsteroidal antipsoriatic agent, derived from the naturally occurring vitamin D. Calcipotriol exhibits a vitamin D-like effect by competing for the 1,25 (OH)2D3 receptor. Calcipotriol is as potent as 1,25 (OH)2D3, the naturally occurring active form of vitamin D, in regulating cell proliferation and cell differentiation, but much less active than 1,25 (OH)2D3 in its effect on calcium…