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ISOPRINOSINE® Rivex Pharma Inosiplex Subacute Sclerosing Panencephalitis Therapy Action And Clinical Pharmacology: Mechanism(s) that might explain the results of the clinical studies employing inosiplex have not been completely elucidated. However, possible antiviral and immunomodulating properties of this drug may be involved. Serum uric acid concentration rose with increasing inosiplex doses. Hyperuricemic levels (greater than 7.5 mg%) were seen at doses equal to or exceeding 3 g/day. At doses of 4…

ISOPTIN® I.V. Knoll Verapamil HCl Antiarrhythmic Action And Clinical Pharmacology: Mode of Action: The mechanism of action of verapamil is believed to be related to its specific cellular action of selectively inhibiting transmembrane influx of calcium in cardiac muscle, coronary and systemic arteries and in cells of the intracardiac conduction system. Verapamil blocks the transmembrane influx of calcium ion through the slow channel (calcium ion antagonism) without affecting to any…

ISOPTIN® SR Knoll Verapamil HCl Antihypertensive Agent Action And Clinical Pharmacology: Verapamil is a calcium ion influx inhibitor (calcium entry blocker or calcium ion antagonist) that exerts its pharmacological effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conducting and contractile myocardial cells. Verapamil exerts antihypertensive effects by inducing vasodilation and reducing peripheral vascular resistance usually without reflex…

ISOCAL® Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: Nutritionally complete and well-balanced to provide the total dietary needs of most tube-fed patients. Precautions: Give additional water as needed to meet the patient’s requirements. Particular attention should be given to water supply for comatose and unconscious patients and others who cannot express the usual sensations of thirst. Additional water is important also when renal concentrating ability is impaired, when there…

ISOCAL® with Fibre Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: A complete liquid diet formulated to provide the nutrient density of Isocal with the associated advantages of fibre. Precautions: Give additional water as needed to meet the patient’s requirements. Particular attention should be given to water supply for comatose and unconscious patients and others who cannot express the usual sensations of thirst. Additional water is important also when renal…

ISOCAL® HN Mead Johnson Therapeutic Nutrient Indications And Clinical Uses: A complete liquid diet formulated to provide well balanced nutrition when used as the sole source of nourishment, particularly in tube fed patients who have normal digestive function. The non-protein-calorie-to-nitrogen ratio of Isocal HN is indicated for patients with burns, sepsis, major injury and surgery. When protein needs are increased with increasing levels of stress; e.g., protein requirement for basic…

IONAMIN® Rhône-Poulenc Rorer Phentermine (Resin Complex) Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drug of this class used in obesity, amphetamine (d- and dl-amphetamine). Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity…

IOPIDINE® 1% IOPIDINE® 0.5% Alcon Apraclonidine HCl Controls Postsurgical Intraocular Pressure Glaucoma Therapy Action And Clinical Pharmacology: Apraclonidine is a relatively selective alpha adrenergic agonist and does not have significant membrane stabilizing (local anesthetic) activity. When instilled into the eye, apraclonidine has the action of reducing intraocular pressure. The precise mechanism of the ocular hypotensive action of apraclonidine is not completely established at this time. Aqueous fluorophotometry studies in man…

IPECAC SYRUP General Monograph, Emetic Pharmacology: Ipecac induces vomiting by both gastric irritation and central stimulation of the chemoreceptor trigger zone. Approximately 95% of patients vomit within 15 to 30 minutes of administration of a therapeutic dose and vomiting usually persists for 30 minutes to 2 hours. Approximately 28 to 60% of an ingested toxin will be removed by emesis if ipecac is given within 5 minutes following ingestion of…

IRON SALTS General Monograph Anemia Therapy Pharmacology: Iron is an important component of a number of enzymes necessary for energy transfer. It is also present in hemoglobin and myoglobin and is important in the metabolism of catecholamines and the functioning of neutrophils. Administration of iron preparations corrects erythropoietic abnormalities which are due to deficiency of iron. Iron does not stimulate erythropoiesis nor does it correct hemoglobin disturbances not caused by…