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ROCEPHIN® Roche Ceftriaxone Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftriaxone results from the inhibition of cell-wall synthesis. In E. coli, ceftriaxone showed a high affinity for penicillin binding proteins (PBP) 1a and 3 and a moderate affinity for 1b and 2. In H. influenzae, the highest affinity was shown for PBP 4 and PBP 5. The binding affinity to PBP 4…

ROBAXIN® ROBAXIN®-750 Whitehall-Robins Methocarbamol Skeletal Muscle Relaxant Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are found primarily as glucuronide and sulfate…

Introduction Robaxacet is an adult medication used to treat muscle spasms and pain. It helps to relax the muscles and decrease the pain. Its effects can be felt within 1 hour. Action And Clinical Pharmacology This product provides a dual approach to the management of discomforts associated with musculoskeletal disorders. The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no…

ROBAXISAL®-C Whitehall-Robins Methocarbamol – ASA – Codeine Phosphate Skeletal Muscle Relaxant – Analgesic Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fibre. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are…

ROBAXISAL® ROBAXISAL® EXTRA STRENGTH Whitehall-Robins Methocarbamol – ASA Skeletal Muscle Relaxant – Analgesic Action And Clinical Pharmacology: The mechanism of action of methocarbamol has not been established, but may be due to general CNS depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fibre. Methocarbamol is metabolized to yield a dealkylated and a hydroxylated product. These 2 metabolites are…

ROBINUL® INJECTABLE Wyeth-Ayerst Glycopyrrolate Anticholinergic Action And Clinical Pharmacology: Glycopyrrolate, like other anticholinergic (antimuscarinic) agents, competitively antagonizes the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. Glycopyrrolate antagonizes muscarinic symptoms (e.g., bronchorrhea, bronchospasm, bradycardia and intestinal hypermotility) induced by cholinergic drugs such as the anticholinesterases. As a premedicant, glycopyrrolate injectable reduces excessive pharyngeal, tracheal and bronchial…

R & C™ Shampoo/Conditioner R & C Pyrethrins – Piperonyl Butoxide Pediculicide – Ovicide Indications And Clinical Uses: For the treatment of infestations with head lice (P. capitis), body lice (P. corporis), crab lice (P. pubis) and their nits. Contra-Indications: Should not be used by persons allergic to chrysanthemum, pyrethrin or synthetic pyrethroids. Precautions: For external use only. Harmful if swallowed. It should not be inhaled. During shampooing, contact should…

R & C™ II Spray R & C Pyrethrins – Piperonyl Butoxide Spray Insecticide Indications And Clinical Uses: For use on lice and lice eggs on garments, bedding, mattresses and furniture. Manufacturers’ Warnings In Clinical States: Not for use on humans or animals. Precautions: Contents under pressure. Do not puncture or incinerate can. Do not use near heat or store at temperatures above 50°C. Avoid spraying in eyes. May be…

RIOPAN® RIOPAN® PLUS Whitehall-Robins Magaldrate Magaldrate – Simethicone Antacid Antacid – Antiflatulent Indications And Clinical Uses: Symptomatic relief of heartburn, indigestion and upset stomach due to excess acid, and relief of gas with Riopan Plus. Precautions: Individuals with kidney disease should not take this product except with the advice and supervision of a physician. Do not take with tetracycline antibiotics. Antacids can interfere with the absorption of iron preparations. Do…

RISPERDAL® Oral Solution RISPERDAL® Tablets Janssen-Ortho Risperidone Tartrate Risperidone Antipsychotic Agent Action And Clinical Pharmacology: Risperidone, a benzisoxazole derivative, is a novel antipsychotic drug which binds with high affinity to the serotonin type 2 (5-HT2), dopamine D2, and a1-adrenergic receptors. Risperidone binds with a lower affinity to the a2-adrenergic and histamine H1 receptors. Risperidone does not bind to dopamine D1 or muscarinic cholinergic receptors. Receptor occupancy was also demonstrated in…