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TONOCARD® AstraZeneca Tocainide HCl Antiarrhythmic Agent Action and Clinical Tocainide is a primary amine analog of lidocaine. Its electrophysiologic properties are similar to those of lidocaine. It possesses class IB properties in the modified electrophysiological classification of antiarrhythmic drugs proposed by Vaughan-Williams. In studies of isolated dog Purkinje fibres, tocainide in concentrations of 1 to 50 g/mL had no significant effect on resting membrane potential, but reduced the amplitude and…

TOPICORT® Preparations Hoechst Marion Roussel Desoximetasone Topical Corticosteroid Action and Clinical Topicort preparations are primarily effective because of their anti-inflammatory, antipruritic and vasoconstrictive actions. Indications And Clinical Uses: For the relief of acute or chronic corticosteroid-responsive dermatoses. Contra-Indications: Topical corticosteroids are contraindicated in untreated bacterial, tubercular, fungal and most viral lesions of the skin (including herpes simplex, vaccinia and varicella) and in those patients with a history of hypersensitivity to…

TOPILENE® Technilab Betamethasone Dipropionate Topical Corticosteroid Availability And Storage: Cream: Each g contains: betamethasone (as dipropionate USP) 0.5 mg (0.05%). Nonmedicinal ingredients: ceteareth-20, cetyl alcohol, glyceryl stearate, light mineral oil, methylparaben, petrolatum, polysorbate 60, propylene glycol, propylene glycol monostearate, propylparaben and purified water. Tubes of 15 and 50 g. Lotion: Each g contains: betamethasone (as dipropionate USP) 0.5 mg (0.05%). Nonmedicinal ingredients: carbomer, isopropyl alcohol, propylene glycol, purified water, sodium…

TOPISONE Technilab Betamethasone Dipropionate Topical Corticosteroid Availability And Storage: Cream: Each g contains: betamethasone 0.5 mg (0.05%) (as dipropionate USP) in a miscible base. Nonmedicinal ingredients: ceteareth-20, cetyl alcohol, glyceryl stearate, light mineral oil, methylparaben, petrolatum, polysorbate 60, propylene glycol, propylparaben and purified water. Tubes of 15 and 50 g. Plastic jars of 450 g. Lotion: Each g contains: betamethasone 0.5 mg (0.05%) (as dipropionate USP). Nonmedicinal ingredients: carbomer, isopropyl…

TOLECTIN® Janssen-Ortho Tolmetin Sodium Anti-inflammatory–Analgesic–Antipyretic Action and Clinical Tolmetin has demonstrated anti-inflammatory, analgesic and antipyretic properties in classical animal test systems. In patients with rheumatoid arthritis, the anti-inflammatory action has been shown by a reduction in joint swelling, pain and duration of morning stiffness, as well as by enhanced grip strength, increased mobility and increased delay in the onset of fatigue. Studies in laboratory animals and man have demonstrated that…

TOLEREX® Novartis Nutrition Elemental Diet Indications And Clinical Uses: A nutritionally complete elemental diet formulated for the nutritional management of patients with impaired digestion and absorption. May include those with inflammatory bowel disease, intestinal atresia, pancreatitis, fistula, partial obstruction, short-gut syndrome. Malnutrition and cachexia. Bowel preparation prior to diagnostic and surgical procedures. Transition diet between parenteral and normal oral feeding. Food sensitivities.: Precautions: Not for parenteral administration. For use only…

TOMYCINE™ CIBA Vision Tobramycin Topical Antibiotic Availability And Storage: Each mL of sterile ophthalmic solution contains: tobramycin 0.3% (3 mg/mL). Nonmedicinal ingredients: benzalkonium chloride (preservative), boric acid, purified water, sodium chloride, sodium hydroxide and/or sulfuric acid (to adjust pH), sodium sulfate and tyloxapol. Plastic squeeze bottles of 5 mL. Avoid contamination of the dropper tip by avoiding contact with the eye, skin or other surfaces. Keep this bottle tightly closed…

TOBREX® Alcon Tobramycin Topical Antibiotic Action and Clinical Like other aminoglycosides, the bactericidal activity of tobramycin is accomplished by specific inhibition of normal protein synthesis in susceptible bacteria, but at the present time, very little is known about this action. It is thought that inhibition of synthesis is due to an action on ribosomes that, in turn, causes bacterial misreading of messenger RNA. Because the ocular concentrations of tobramycin achieved…

TOFRANIL® Novartis Pharmaceuticals Imipramine HCl Antidepressant Action and Clinical Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. It possesses anticholinergic properties which are responsible for certain of its side effects. The mechanism of action of imipramine and other tricyclic antidepressants is not well established, but it is thought that it might be related to their…

TISSEEL® KIT VH Baxter Fibrin Sealant Description: Tisseel’s action simulates key features of the physiological process of wound closure. A highly concentrated fibrinogen aprotinin solution, which among other ingredients contains Factor XIII, and a solution of thrombin and calcium chloride are applied to the wound area, where the mixture coagulates. The presence of Factor XIII causes the fibrin to crosslink, which gives the coagulum additional resilience. Tisseel-sealant is a tissue glue…