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TICLID® Roche Ticlopidine HCl Inhibitor of Platelet Function Action and Clinical Uses: Ticlopidine is an inhibitor of platelet aggregation. It causes a time and dose-dependent inhibition of platelet aggregation and release of platelet factors, as well as a prolongation of bleeding time. The drug has no significant in vitro activity. The exact mechanism of action is not fully characterized, but does not involve inhibition of the prostacyclin/thromboxane pathways or platelet…

TILADE® Rh´ne-Poulenc Rorer Nedocromil Sodium Bronchial Anti-inflammatory Agent Action and Clinical Uses: Nedocromil sodium is a new chemical entity that inhibits the release of inflammatory mediators from a variety of cell types occurring in the lumen and in the mucosa of the bronchial tree. When it is administered topically to the bronchi, it displays specific anti-inflammatory properties. Laboratory experiments have shown that nedocromil sodium prevents the release of inflammatory chemotactic…

THYRO-BLOCK® Carter Horner Potassium Iodide Thyroid Blocking Agent Action and Clinical Uses: Potassium iodide, an ionic thyroid blocking agent, acts on the transport of iodide into and out of the thyroid. When given in sufficient amounts, entry of radioiodide into the gland can be virtually prevented. The onset of inhibition is rapid and is readily demonstrated 30 minutes after oral administration. An important factor in obtaining satisfactory acute block of…

TI-U-LAC® HC Spectropharm Dermatology Hydrocortisone-Urea Topical Corticosteroid Availability And Storage: Each mL of white, odorless, washable lotion contains: hydrocortisone 2.5% and urea 10%. Nonmedicinal ingredients: arlacel, cetyl glycol, Germall, lactic acid, mineral oil, lauryl sulfate, propylene glycol, Veegum, water and white petrolatum. Plastic bottles of 60 mL. Protect from excessive heat. Store at room temperature. Avoid freezing. TI-U-LAC® HC Spectropharm Dermatology Hydrocortisone-Urea Topical Corticosteroid

THYROID HORMONE Parke-Davis Desiccated Thyroid Hypothyroidism Therapy Action and Clinical Uses: The principal pharmacologic effect of exogenous thyroid hormones is to increase the metabolic rate of body tissues. The normal thyroid gland contains approximately 200 g of levothyroxine (T 4)/g of gland, and 15 g of triiodothyronine (T 3)/g. The ratio of these two hormones in the circulation does not represent the ratio in the thyroid gland, since about 80%…

THEOPHYLLINE Technilab Bronchodilator Availability And Storage: Each 15 mL of fruit-flavored elixir contains: theophylline anhydrous 80 mg. Nonmedicinal ingredients: alcohol, artificial coloring and flavorings, FD&C Yellow #6, methylparaben, natural flavoring, propylparaben, purified water, sodium benzoate, sorbitol and sucrose. Bottles of 500 mL. Store between 15 and 30°C. THEOPHYLLINE Technilab Bronchodilator

THIOTEPA Wyeth-Ayerst Cytotoxic Agent Action and Clinical Uses: Thiotepa is a cytotoxic agent of the polyfunctional alkylating type (more than one reactive ethylenimine group) related chemically and pharmacologically to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs…

THROMBATE III® Bayer Antithrombin III (Human) Anticoagulant Action and Clinical Uses: Antithrombin III (AT-III), an alpha 2-glycoprotein of molecular weight 58 000, is normally present in human plasma at a concentration of approximately 12.5 mg/dL and is the major plasma inhibitor of thrombin. Inactivation of thrombin by AT-III occurs by formation of a covalent bond resulting in an inactive 1:1 stoichiometric complex between the two, involving an interaction of the active serine…

THEOCHRON® SR Riva Theophylline Bronchodilator Action and Clinical Theophylline is a bronchodilator which directly relaxes the smooth muscle of the bronchial airways and pulmonary and coronary blood vessels. These actions may be mediated through inhibition of phosphodiesterase and a resultant increase in intracellular cyclic AMP. Theophylline sustained release tablets produce peak blood levels of theophylline between 5 and 8 hours following dosing in adults. Once a steady state level has…

THEOLAIR™-SR 3M Pharmaceuticals Theophylline Bronchodilator Availability And Storage: 250 mg: Each white, round, sustained-release tablet, “3M” imprint on one face, “SR-250” bisect score on the other face, contains: theophylline (anhydrous) 250 mg. Nonmedicinal ingredients: cellulose acetate phthalate, lactose and magnesium stearate. Tartrazine-free. Bottles of 100. 300 mg: Each white, oval-shaped, sustained-release tablet, “3M” imprint on one face, “SR-300” bisect bar on the other face, contains: theophylline (anhydrous) 300 mg. Nonmedicinal…