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CLOMID® Hoechst Marion Roussel Clomiphene Citrate Ovulatory Agent Action And Clinical Pharmacology: Clomiphene is an orally-administered, nonsteroidal agent which may induce ovulation in anovulatory women in appropriately selected cases. The ovulatory response to cyclic clomiphene therapy appears to be mediated through increased output of pituitary gonadotropins, which in turn stimulate the maturation and endocrine activity of the ovarian follicle and the subsequent development and function of the corpus luteum. The…

CITROTEIN® Novartis Nutrition Therapeutic Nutrient Indications And Clinical Uses: For patients requiring oral supplementation. It is lactose-free, low residue and is appropriate for fortification of the clear liquid diet. Precautions: Not recommended for parenteral administration. Dosage: 6 servings [1 520 mL or 4 264 kJ (1 018 kcal)] provides at least 100% of the Canadian RNI (adult males, 25 to 49) for protein and essential vitamins and minerals. Availability And…

CLAFORAN® Hoechst Marion Roussel Cefotaxime Sodium Antibiotic Action And Clinical Pharmacology: Animal studies demonstrate that cefotaxime has no significant effect on the CNS, cardiovascular and respiratory systems, kidneys, blood clotting mechanisms and blood glucose levels. There is a dose-dependent increase in serum levels after i.v. administration of 500 mg, 1 and 2 g of cefotaxime (38.9, 101.7 and 214.4 g/mL respectively), without alteration in the elimination half-life. The biological half-life…

CLARITIN® EXTRA Schering Loratadine – Pseudoephedrine Sulfate Histamine H1-Receptor Antagonist – Sympathomimetic Amine Action And Clinical Pharmacology: Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1 receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at 2 hours and persists throughout the 24 hour observation period. Single oral doses up to 160 mg…

CLARITIN® Schering Loratadine Histamine H1-Receptor Antagonist Action And Clinical Pharmacology: Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at 2 hours and persists throughout the 24-hour observation period. Single oral doses up to 160 mg and repeat daily doses of 40 mg for up…

CITRO-MAG® Rougier Magnesium Citrate Laxative Indications And Clinical Uses: A laxative or purgative. Preparation of the colon for x-ray examination. Contra-Indications: Abdominal pain, nausea or vomiting. Known or suspected intestinal obstruction. Precautions: Frequent or prolonged use may result in dependence on laxatives. Dosage: Adults: as a laxative: 1/4 to 1/2 bottle; as a purgative: 1 bottle before breakfast or as prescribed before x-ray examination. Children (6 to 12 years): 30…

CITROCARBONATE® Roberts Bicarbonate – Tartrate Compound Urinary Alkalizer Indications And Clinical Uses: As a systemic and urinary alkalinizer, gastric antacid. Precautions: Consider the sodium content in administration to patients on sodium free diets. Chronic, prolonged use may produce metabolic alkalosis. Dosage And Administration: Adults: 1 to 2 teaspoonfuls of powder in a glass of cold water, 15 minutes to 2 hours after meals, or as directed by a physician. Children:…

CITANEST® 4% PLAIN CITANEST® 4% FORTE Astra Prilocaine HCl Prilocaine HCl – Epinephrine Local Anesthetic for Infiltration and Nerve Block Action And Clinical Pharmacology: Mechanism of Action: Prilocaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses thereby, effecting local anesthetic action. Local anesthetics of the amide type are thought to act within sodium channels of the nerve membrane. Onset of Action: When used for infiltration…

CIDOMYCIN® Hoechst Marion Roussel Gentamicin Antibiotic Action And Clinical Pharmacology: Gentamicin is a bactericidal antibiotic which affects bacterial growth by specific inhibition of normal protein synthesis in susceptible bacteria. Gentamicin Serum Levels Via the I.M. Route in Adults and Children: In patients with normal renal function, peak serum concentrations, bactericidal for susceptible bacteria, occur between 30 and 90 minutes after injection. The peak serum level (mg/L) is usually 4 times…

CHRONOVERA® Searle Verapamil HCl Antihypertensive – Antianginal Agent System Components and Performance: Chronovera is a formulation designed to initiate the release of verapamil approximately 4 to 5 hours after ingestion by means of a delay coating and thereafter to provide a constant rate of release over 12 hours. The tablet is comprised of a semipermeable membrane surrounding a drug core that is osmotically active. The core itself is divided into…