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COLPERMIN™ R & C Peppermint Oil Symptomatic Relief of Irritable Bowel Syndrome Action And Clinical Pharmacology: The mechanism of action of peppermint oil or its major component, menthol, in reducing lower bowel motility has not been completely elucidated. It has been postulated that peppermint oil exerts its gastrointestinal smooth muscle inhibitory effect by altering calcium ion transport. Using intraluminal pressure recordings and ultrasound measurements of colonic activity it has been…

COATED ASPIRIN® Bayer Consumer ASA Analgesic – Anti-inflammatory – Antipyretic Indications And Clinical Uses: 80 mg: For use in children only for rheumatic and arthritic pain under the supervision of a physician. Do not use to treat fever. 325 mg/500 mg/650 mg: For the temporary relief of arthritic and rheumatic pain, muscle aches, joint pain and back pain. Coated Aspirin has a special enteric coating recommended by doctors to help…

CoACTIFED® Preparations Glaxo Wellcome Triprolidine HCl – Codeine Phosphate – Pseudoephedrine HCl Antihistamine – Antitussive – Decongestant Indications And Clinical Uses: CoActifed Expectorant: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum. CoActifed Syrup and Tablets: The treatment of cough associated with inflamed mucosa. Contra-Indications: This drug should not be used in newborn or premature infants. Hypersensitivity to codeine phosphate or other narcotics, triprolidine hydrochloride, or…

CODEINE CONTIN® Purdue Frederick Codeine Monohydrate – Codeine Sulfate Trihydrate Opioid Analgesic Action And Clinical Pharmacology: Codeine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, codeine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and…

COGENTIN® MSD Benztropine Mesylate Antiparkinsonian Agent Action And Clinical Pharmacology: Benztropine is a synthetic compound resulting from the combination of the active portions of atropine and diphenhydramine. Benztropine possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism. Benztropine antagonizes the effect of acetylcholine. This decreases the imbalance between the neurotransmitters, acetylcholine and dopamine, which may improve the symptoms…

CLOPIXOL® CLOPIXOL-ACUPHASE® CLOPIXOL® DEPOT Lundbeck Zuclopenthixol Dihydrochloride Zuclopenthixol Acetate Zuclopenthixol Decanoate Antipsychotic Action And Clinical Pharmacology: Zuclopenthixol, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and dopamine D2 receptors. Zuclopenthixol also has high affinity for a1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and a2-adrenergic receptors. Pharmacokinetics: The pharmacokinetics of zuclopenthixol appear to be linear over…

CLOZARIL® Novartis Pharmaceuticals Clozapine Antipsychotic Agent Action And Clinical Pharmacology: Clozapine, a dibenzodiazepine derivative, is an atypical antipsychotic drug because its profile of binding to dopamine receptors and its effects on various dopamine-mediated behaviors differ from those exhibited by conventional antipsychotics. In contrast to conventional antipsychotics, clozapine produces little or no prolactin elevation. Clozapine exerts potent anticholinergic, adrenolytic, antihistaminic and antiserotoninergic activity. Controlled clinical trials indicate that clozapine improves both…

CLAVULIN® SmithKline Beecham Amoxicillin – Clavulanate Potassium Antibiotic – b-Lactamase Inhibitor Action And Clinical Pharmacology: Amoxicillin exerts a bactericidal action against sensitive organisms during the stage of active multiplication through the inhibition of the biosynthesis of bacterial cell wall mucopeptides. Clavulanic acid inhibits specific b-lactamases of some microorganisms and allows amoxicillin to inhibit amoxicillin (ampicillin) resistant organisms which produce clavulanic acid sensitive b-lactamases. Indications And Clinical Uses: For the treatment…

CLIMACTERON® Sabex Testosterone – Estradiol Estrogen Androgen Therapy Indications And Clinical Uses: As replacement therapy for the control of menopausal symptoms and for estrogen deficiency-induced osteoporosis where estrogen deficiency is naturally or surgically induced. It should be used only in patients available for reevaluation at periodic intervals. Each reevaluation should determine the need for continued therapy and, if continuing therapy is required, whether a downward readjustment of dosage can be…

CLIMARA® Berlex Canada Estradiol-17b Estrogen Action And Clinical Pharmacology: Climara is composed of a translucent polyethylene film with an acrylate adhesive matrix containing estradiol-17b. Upon application to intact skin, Climara provides continuous systemic delivery of estrogen by releasing estradiol-17b, the major estrogenic hormone secreted by the human ovary. Estradiol-17b is the predominant estrogen produced by the ovaries in premenopausal women. Administration of transdermal estradiol to postmenopausal women elevates plasma estradiol…