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CARBOPLATIN INJECTION Faulding Antineoplastic Action And Clinical Pharmacology: Carboplatin is a synthetic analogue of cisplatin. Like cisplatin, carboplatin interferes with DNA intrastrand and interstrand crosslinks in cells exposed to the drug. DNA reactivity has been correlated with cytotoxicity. Following administration of carboplatin in man, linear relationships exist between dose and plasma concentrations of total and free ultrafilterable platinum. The area under the plasma concentration versus time curve for total platinum…

CANESTEN® Topical Bayer Consumer Clotrimazole Antifungal Action And Clinical Pharmacology: Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole brings about inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is completely or partially inhibited, the cell is no longer able to construct an intact cell membrane. This leads to death of the fungus. Exposure of C. albicans to…

CANESTEN® Vaginal Bayer Consumer Clotrimazole Antifungal Action And Clinical Pharmacology: Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole brings about inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is completely or partially inhibited, the cell is no longer able to construct an intact cell membrane. This leads to death of the fungus. Exposure of C. albicans to…

CANTHACUR® Pharmascience Cantharidin Vesicant Indications And Clinical Uses: For the topical use of removal of benign epithelial growths such as warts (verruca vulgaris) or molluscum contagiosum. Because of the absence of scarring, cantharidin is useful for treating exposed areas where cosmetic results are important. Painless application and the absence of instruments makes it especially useful for treating children. Contra-Indications: Hypersensitivity to the ingredients. Avoid alcoholic beverages for several hours after…

Indications And Clinical Uses: For the topical use of removal of benign epithelial growths such as warts (verruca vulgaris), especially plantar, mosaic, periungual, and molluscum contagiosum. Recommended for resistant and heavily keratinized warts. Because of the absence of scarring, the mixture is useful for treating exposed areas where cosmetic results are important. Contraindications: Hypersensitivity to the ingredients. Avoid alcoholic beverages for several hours after treatment. Precautions: Canthacur-PS is a potent…

CALTINE® Ferring Synthetic Calcitonin Salmon (Salcatonin) Paget’s Disease Therapy – Hypercalcemia Treatment Action And Clinical Pharmacology: Salmon calcitonin participates in the regulation of the homeostasis of calcium by acting primarily on the bone, in Paget’s disease presumably by an initial blocking effect on accelerated bone resorption. The rate of bone turnover appears to be decreased. The pharmacologic activity of salmon calcitonin is the same as that of the endogenously produced…

CALSAN® Novartis Consumer Health Calcium Carbonate Calcium Supplement Indications And Clinical Uses: As a dietary supplement where calcium intake may be inadequate: childhood, adolescence, adulthood, pregnancy, lactation, perimenopausal and postmenopausal women and in the aged. In the treatment of calcium deficiency states which may occur in diseases such as hypoparathyroidism (acute and chronic), pseudohypoparathyroidism, postmenopausal and senile osteoporosis, rickets and osteomalacia. Contra-Indications: Hypercalcemia and hypercalciuria (e.g. hyperparathyroidism, vitamin D overdosage,…

CAMPTOSAR™ Pharmacia & Upjohn Irinotecan HCl Trihydrate Antineoplastic Caution: Irinotecan should be administered only under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. Irinotecan can cause both an early and late form of diarrhea. Both forms of diarrhea may be severe. Early diarrhea (occurring during or within 24 hours of irinotecan administration) may be preceded by sweats and abdominal cramping. Late diarrhea (occurring…

CALTRATE® 600 CALTRATE® 600 +D CALTRATE® PLUS Whitehall-Robins Calcium Carbonate Calcium Carbonate – Vitamin D Calcium Carbonate – Vitamin D – Magnesium – Zinc – Copper – Manganese Calcium Supplement Indications And Clinical Uses: As a dietary supplement where calcium intake may be inadequate: during childhood, adolescence, pregnancy, lactation, and in postmenopausal women and the aged. In the treatment of calcium deficiency states which may occur in diseases such as…

CALCIUM-SANDOZ® Novartis Consumer Health Calcium Preparations Calcium Therapy Indications And Clinical Uses: As a dietary supplement where calcium intake may be inadequate: childhood and adolescence, pregnancy and lactation, postmenopausal females and in the aged. In the treatment of calcium deficiency states which may occur in diseases such as: tetany of the newborn (as a supplement to parenterally administered calcium), hypoparathyroidism (acute and chronic), pseudo-hypoparathyroidism, postmenopausal and senile osteoporosis, rickets and…