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COLY-MYCIN® M PARENTERAL Parke-Davis Sodium Colistimethate Antibiotic Action And Clinical Pharmacology: Sodium colistimethate is the pentasodium salt of the penta (methanesulfonic acid) derivative of colistin. Colistin is a basic polypeptide antibiotic substance produced by the growth of Bacillus polymyxa var. colistinus. Colistin derivatives appear to alter the permeability of the bacterial cytoplasmic membrane, causing leakage of intracellular nucleosides. The drugs are bactericidal in action. I.M. administration of sodium colistimethate with…

COLYTE™ R & C PEG-3350 – Electrolytes Colon Electrolyte Lavage Preparation Action And Clinical Pharmacology: Colyte cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or secretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance. Indications And Clinical Uses: For bowel cleansing prior…

COMBANTRIN® Pfizer Consumer Pyrantel Pamoate Anthelmintic Action And Clinical Pharmacology: Pyrantel exerts its anthelmintic effect by interfering with the neuromuscular function of the parasite. It is also a cholinesterase inhibitor and a ganglionic stimulant. The anthelmintic activity of pyrantel has been demonstrated in several animal models. These tests carried out in mice and dogs showed the compound to be effective against intestinal nematodes representative of those found in humans, such…

COMBIVENT® Inhalation Aerosol Boehringer Ingelheim Ipratropium Bromide – Salbutamol Sulfate Bronchodilator Action And Clinical Pharmacology: Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the b2-adrenergic bronchodilator, salbutamol sulfate. Each actuation from the valve delivers 20 µg ipratropium bromide and 120 µg salbutamol sulfate (equivalent to 100 µg salbutamol base). Ipratropium bromide is a quaternary ammonium derivative of atropine and is an anticholinergic with bronchodilator properties….

Colchicine (Oral) General Monograph, Gout Therapy Action And Clinical Pharmacology: Although its exact mode of action in the relief of gout is not completely understood, colchicine is known to decrease the inflammatory response to urate crystal deposition by inhibiting migration of leukocytes, to interfere with urate deposition by decreasing lactic acid production by leukocytes, to interfere with kinin formation and to diminish phagocytosis and the subsequent anti-inflammatory response. The anti-inflammatory…

COLACE® Roberts Docusate Sodium Stool Softener Indications And Clinical Uses: The management of constipation due to hard stools, in painful anorectal conditions, in cardiac and other conditions in which maximum ease of passage is desirable to avoid difficult or painful defecation, and when peristaltic stimulants are contraindicated. Contra-Indications: Presence of abdominal pain, nausea or vomiting. Precautions: Do not administer concomitantly with mineral oil: increased absorption of the oil may result….

COLESTID® Pharmacia & Upjohn Colestipol HCl Oral Antihypercholesterolemic Action And Clinical Pharmacology: Colestipol is hygroscopic, water insoluble, and it is neither hydrolyzed by digestive enzymes nor is it absorbed. Colestipol binds with bile acids in the intestine forming a complex that is excreted in the feces. This non-systemic action results in a continuous, partial removal of bile acids from the enterohepatic circulation preventing their reabsorption. This increased fecal loss of…

COLPERMIN™ R & C Peppermint Oil Symptomatic Relief of Irritable Bowel Syndrome Action And Clinical Pharmacology: The mechanism of action of peppermint oil or its major component, menthol, in reducing lower bowel motility has not been completely elucidated. It has been postulated that peppermint oil exerts its gastrointestinal smooth muscle inhibitory effect by altering calcium ion transport. Using intraluminal pressure recordings and ultrasound measurements of colonic activity it has been…

COATED ASPIRIN® Bayer Consumer ASA Analgesic – Anti-inflammatory – Antipyretic Indications And Clinical Uses: 80 mg: For use in children only for rheumatic and arthritic pain under the supervision of a physician. Do not use to treat fever. 325 mg/500 mg/650 mg: For the temporary relief of arthritic and rheumatic pain, muscle aches, joint pain and back pain. Coated Aspirin has a special enteric coating recommended by doctors to help…

CoACTIFED® Preparations Glaxo Wellcome Triprolidine HCl – Codeine Phosphate – Pseudoephedrine HCl Antihistamine – Antitussive – Decongestant Indications And Clinical Uses: CoActifed Expectorant: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum. CoActifed Syrup and Tablets: The treatment of cough associated with inflamed mucosa. Contra-Indications: This drug should not be used in newborn or premature infants. Hypersensitivity to codeine phosphate or other narcotics, triprolidine hydrochloride, or…