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VEXOL™ Alcon Rimexolone Corticosteroid Action And Clinical Pharmacology: Rimexolone is an anti-inflammatory corticosteroid. Corticosteroids suppress the inflammatory response to a variety of inciting agents of a mechanical, chemical, or immunological nature. They inhibit edema, cellular infiltration, capillary dilatation, fibroblastic proliferation, deposition of collagen and late cicatrization. Corticosteroids are capable of producing a rise in intraocular pressure in susceptible individuals. Placebo-controlled clinical studies demonstrated that rimexolone ophthalmic suspension is efficacious for…

VELBE® Lilly Vinblastine Sulfate Antineoplastic Agent Action And Clinical Pharmacology: Vinblastine has been used for the palliative treatment of a variety of malignant neoplastic conditions. In susceptible clinical cases, vinblastine sulfate has produced temporary reduction in the size or temporary disappearance of some tumors. It has relieved pain and other symptoms and allowed some patients to regain appetite and weight. Periods of remission have varied from patient to patient. Experimental…

VENTOLIN® VENTODISK® VENTODISK® DISKHALER® VENTOLIN® ROTACAPS® VENTOLIN® ROTAHALER® VENTOLIN® RESPIRATOR SOLUTION VENTOLIN® NEBULES P.F. Glaxo Wellcome Salbutamol Bronchodilator – Beta2-adrenergic Stimulant Action And Clinical Pharmacology: Salbutamol produces bronchodilation through stimulation of beta2-adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of bronchial muscle fibres. This action is manifested by an improvement in pulmonary function as demonstrated by spirometric measurements. At therapeutic doses, salbutamol has little action on the beta1-adrenergic receptors…

VEPESID® Bristol Etoposide Antineoplastic Action And Clinical Pharmacology: Etoposide is a semi-synthetic derivative of podophyllotoxin. In vitro, etoposide has cytostatic action, which prevents the cells from entering mitosis or destroys them in the premitotic phase. Etoposide interferes with the synthesis of DNA and has a secondary effect on arresting cells in resting (G2) phase in experiments with human lymphoblastic cell lines. Etoposide has a marked action on human hemopoietic cells…

VANQUIN® Warner-Lambert Consumer Healthcare Pyrvinium Pamoate Oxyuriasis Therapy Indications And Clinical Uses: Treatment of pinworms. Contra-Indications: In patients who have previously exhibited hypersensitivity to the drug. Precautions: To forestall undue concern and help avoid accidental staining, patients and parents should be advised of the staining properties of pyrvinium. Parents and patients should be informed that pyrvinium will color the stool a bright red. This is not harmful to the patient….

VALIUM® ROCHE® INJECTION Roche Diazepam Anxiolytic – Sedative Action And Clinical Pharmacology: Diazepam is an anxiolytic-sedative drug useful in the symptomatic relief of anxiety and tension states. It has also adjunctive value in the relief of certain neurospastic conditions and in certain cases, its anticonvulsant activity has been found useful in controlling status epilepticus. Peak blood levels after the i.v. administration of diazepam injection are reached within 15 minutes as…

VALISONE-G® Schering Betamethasone Valerate – Gentamicin Sulfate Topical Corticosteroid – Antibiotic Action And Clinical Pharmacology: Valisone-G provides the combined anti-inflammatory, anti-allergic, and antipruritic actions of betamethasone valerate with the antibacterial topical effect of gentamicin. Indications And Clinical Uses: The topical management of secondarily infected allergic or inflammatory dermatoses responsive to corticosteroid therapy, such as contact dermatitis, seborrheic dermatitis, neurodermatitis, intertrigo, exfoliative dermatitis, stasis dermatitis and psoriasis. Secondary infections caused by…

VALISONE® Scalp Lotion Schering Betamethasone Valerate Topical Corticosteroid Indications And Clinical Uses: The management of dermatoses of the scalp. May also be used in corticosteroid responsive dermatoses. Contra-Indications: See Celestoderm-V. Manufacturers’ Warnings In Clinical States: This lotion contains isopropyl alcohol, and may cause stinging or burning upon application to abraded or sun-burned skin. Do not use in or near the eyes. Precautions and Adverse Effects: See Celestoderm-V. Dosage: Apply a…

UROMITEXAN™ Bristol Mesna Uroprotector Action And Clinical Pharmacology: Mesna is rapidly and easily converted by autooxidation to its only metabolite disodium 2,2¢-dithio-bis ethane sulfonate (mesna disulfide, dimesna), forming a disulfide link. Following i.v. injection, only a small portion of the administered dose is detected in the blood as a reactive thiol compound (mesna). Mesna disulfide remains in the intravascular space and is rapidly forwarded to the kidney. In the renal…

URSOFALK® Axcan Pharma Ursodiol Litholytic Agent – Cholestatic Liver Diseases Action And Clinical Pharmacology: Ursodiol, a naturally occurring bile acid, is present as a minor fraction of the total human bile acids. Oral administration of ursodiol increases this fraction in a dose related manner, to become the major biliary acid. Since in patients with gallstones, the total bile acid pool size is generally reduced, the exogenous supply of ursodiol helps…