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CORTENEMA® Axcan Pharma Hydrocortisone Glucocorticoid Indications And Clinical Uses: An adjunct in the treatment of nonspecific inflammatory diseases involving the rectum, sigmoid and left colon such as idiopathic ulcerative colitis, ulcerative proctitis, regional enteritis (granulomatous colitis) with left side involvement, proctitis, proctocolitis, and radiation proctitis. Contra-Indications: Local contraindications to the use of intrarectal steroids include obstruction, abscess, perforation, peritonitis, fresh intestinal anastomoses, extensive fistulas and sinus tracts. Active tuberculosis (active,…

BREVICON® 0.5/35 Searle Norethindrone – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. tag_IndicationsIndications Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis…

BRICANYL® Tablets BRICANYL® TURBUHALER® Astra Terbutaline Sulfate Bronchodilator Action And Clinical Pharmacology: Terbutaline produces bronchodilation by stimulation of the B2 adrenergic receptors in bronchial smooth muscle, thereby causing relaxation of muscle fibres. This action is manifested by an increase in pulmonary function as demonstrated by FEV1 measurements. Terbutaline also produces a decrease in airway and pulmonary resistance. Following inhalation of terbutaline Turbuhaler, a significant improvement in pulmonary function measurements is…

BRADOSOL® BRADOSOL® EXTRA-STRENGTH Novartis Consumer Health Hexylresorcinol Antiseptic Indications And Clinical Uses: For the relief of sore throat. Precautions: If symptoms persist for more than 7 days, consult a physician. Dosage: 1 lozenge every 2 to 3 hours, as required. Not recommended for children under 3 years, unless on the advice of a physician. Availability And Storage: Bradosol: Each lozenge contains: hexylresorcinol 2.4 mg in a pleasant-tasting, candy-flavored base. Nonmedicinal…

BREVIBLOC® Zeneca Esmolol HCl Beta-adrenergic Receptor Blocking Agent Action And Clinical Pharmacology: Esmolol is a beta-adrenergic receptor blocking agent with predominant blocking effect on beta-1 receptors. It does not possess significant intrinsic sympathomimetic or membrane stabilizing activity. Esmolol, which is administered only i.v., has a rapid onset and a short duration of action. Pharmacodynamics: In human electrophysiology studies, esmolol produced effects typical of a beta-blocker: a decrease in the heart…

BLOCADREN® Frosst Timolol Maleate Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Timolol is a beta-adrenergic receptor blocking agent. The mechanism of the antihypertensive effect of beta- adrenergic receptor blocking agents has not yet been established. Among the factors that may be involved are: competitive ability to antagonize catecholamine-induced tachycardia at the beta receptor sites in the heart, thus decreasing cardiac output; inhibition of renin release by the kidneys; inhibition…

BONAMINE™ Pfizer Meclizine HCl Antiemetic Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine structures may be the site of action. Indications And Clinical Uses: For prophylaxis and symptomatic relief of nausea, vomiting and vertigo associated with motion…

BONEFOS® Rh´ne-Poulenc Rorer Clodronate Disodium Bone Metabolism Regulator – Antihypercalcemic Agent Action And Clinical Pharmacology: Clodronate belongs to the class of bisphosphonates which bind to hydroxyapatite and inhibit formation and dissolution of calcium crystals in vitro. Bisphosphonates including clodronate act on the bony skeleton causing reduction of normal and abnormal bone resorption. Clodronate alters the activities of osteoclasts and osteoblasts and the balance of bone resorption and bone formation is…

BLENOXANE® Bristol Bleomycin Sulfate Antineoplastic – Antibiotic Action And Clinical Pharmacology: Although the exact mechanism of action of bleomycin is unknown, available evidence indicates that the main mode of action is inhibition of DNA synthesis with some evidence of inhibition of RNA and protein synthesis. The major route of excretion of bleomycin is the kidney, with 60 to 70% of an administered dose recovered in the urine as active bleomycin….

BLEOMYCIN SULFATE USP Faulding Antineoplastic Action And Clinical Pharmacology: Experiments with isolated DNA have shown that bleomycin binds to the DNA molecule and cleaves it. This results in the inhibition of DNA synthesis. There is also evidence of lesser inhibition of RNA and protein synthesis. Bleomycin exhibits a wide spectrum of in vitro and in vivo activity. It demonstrates inhibition of DNA synthesis in E. coli, B. subtilis, Ehrlich ascites…