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  CYCLOPENTOLATE HCl General Monograph, Cycloplegic – Mydriatic – Anticholinergic Cyclopentolate is an anticholinergic agent that induces relaxation of the sphincter of the iris and the ciliary muscles. When applied topically to the eyes, it causes a rapid, intense cycloplegic and mydriatic effect that is maximal in 15 to 60 minutes; recovery usually occurs within 24 hours. The cycloplegic and mydriatic effects are slower in onset and longer in duration…

CYKLOKAPRON® Pharmacia & Upjohn Tranexamic Acid Antifibrinolytic Agent Action And Clinical Pharmacology: Tranexamic acid produces an antifibrinolytic effect by competitively inhibiting the activation of plasminogen to plasmin. It is also a weak noncompetitive inhibitor of plasmin. These properties make possible its clinical use as an antifibrinolytic in the treatment of both general and local fibrinolytic hemorrhages. It has an action mechanism similar to, but about 10 times more potent in…

CRIXIVAN® MSD Indinavir Sulfate HIV Protease Inhibitor Action And Clinical Pharmacology: Indinavir is a selective protease inhibitor active against the Human Immunodeficiency Virus (HIV-1). Mechanism of Action: HIV protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of…

CUPRIMINE® MSD Penicillamine Chelating Agent Action And Clinical Pharmacology: As a chelating agent, penicillamine removes copper and lead from the body. In copper chelation, from in vitro studies which indicate that one atom of copper combines with 2 molecules of penicillamine. It would appear that 1 g of penicillamine should be followed by the excretion of about 200 mg of copper; however, the actual amount excreted is about 1% of…

CYCLOCORT® Stiefel Amcinonide Topical Corticosteroid Indications And Clinical Uses: The relief of inflammatory manifestations of acute and chronic corticosteroid-responsive dermatoses, such as atopic dermatitis, contact and eczematous dermatoses, psoriasis and neurodermatitis. Topical corticosteroid therapy, although responsible for remissions of dermatoses, especially of allergic origin, cannot be expected to prevent recurrence. In the case of contact or allergic dermatitis, it is important to investigate causal factors and to remove the offending…

CYCLEN® Janssen-Ortho Norgestimate – Ethinyl Estradiol Oral Contraceptive Action And Clinical Pharmacology: The primary mechanism of action is an inhibition of ovulation. Additionally, other effects caused by the treatment (e.g., alteration of the endometrium and the thickening of the cervical mucus), appear to interfere with implantation and conception. Indications And Clinical Uses: Conception control. Contra-Indications: History of/or actual thrombophlebitis or thromboembolic disorders; history of/or actual cerebrovascular disorders; history of/or actual…

COVERSYL® Servier Perindopril Erbumine Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Perindopril is a nonsulphydryl angiotensin-converting enzyme (ACE) inhibitor, which is used in the treatment of hypertension. Following oral administration, perindopril is rapidly hydrolyzed to perindoprilat, its principal active metabolite. Angiotensin-converting enzyme catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE activity leads…

CREO-RECTAL® Nadeau Diphenylpyraline HCl – Camphor – Guaiacol Expectorant – Antihistaminic Indications And Clinical Uses: For the temporary relief of coughs due to colds, bronchitis, bronchial asthma. Contra-Indications: Hypersensitivity to any of the components. Precautions: Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or other drugs with CNS…

CREON® 10 Solvay Pharma Pancreatic Enzymes Digestant Indications And Clinical Uses: For replacement therapy where digestion is not adequate due to pancreatic exocrine insufficiency as in cystic fibrosis, chronic pancreatitis, steatorrhea, post-pancreatectomy, post-gastrointestinal bypass surgery (e.g., gastroenterostomy) and ductal obstruction from neoplasm. Contra-Indications: Patients with known hypersensitivity to porcine proteins or pancreatic enzymes. Do not use during the early stages of acute pancreatitis. Perianal irritation, and rarely, inflammation, could occur…

CREON® 25 Solvay Pharma Pancreatic Enzymes Digestant Indications And Clinical Uses: For replacement therapy where digestion is not adequate due to pancreatic exocrine insufficiency as in cystic fibrosis, chronic pancreatitis, steatorrhea and postpancreatectomy, post gastrointestinal bypass surgery (e.g., gastroenterostomy) and ductal obstruction from neoplasm. Contra-Indications: Patients with known hypersensitivity to porcine proteins or pancreatic enzymes. Do not use during the early stages of acute pancreatitis. Pregnancy and Lactation: There is…