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PEGLYTE™ Pharmascience PEG-Electrolytes Gastrointestinal Lavage Action And Clinical Pharmacology: Peglyte cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or secretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance. Indications And Clinical Uses: For bowel cleansing prior to colonoscopy or barium enema x-ray…

PEDIALYTE® PEDIALYTE® FREEZER POPS Abbott Oral Electrolyte Maintenance Solution Electrolyte Maintenance Indications And Clinical Uses: Prevents dehydration and restores fluids and minerals lost in patients with mild or moderate diarrhea and other conditions causing mild to moderate dehydration; for maintenance of body water and electrolytes and prevention of dehydration secondary to acute diarrhea in infants and children; for oral supplementation and for maintenance following corrective parenteral therapy of severe dehydration;…

PEDIAPRED® Rh´ne-Poulenc Rorer Prednisolone Sodium Phosphate Glucocorticoid – Anti-inflammatory Action And Clinical Pharmacology: Prednisolone sodium phosphate is a synthetic adrenocortical steroid derivative with predominantly glucocorticoid properties possessing anti-inflammatory and immunosuppressive action. Prednisolone sodium phosphate belongs to the pharmacologic class of glucocorticoid/anti-inflammatory drugs which, following systemic absorption, diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes may enter the cell nucleus, bind to DNA and stimulate transcription of…

PEDIASURE™ Abbott Therapeutic Nutrient Description: PediaSure liquid nutrition for children is an isotonic enteral nutritional product designed to provide complete balanced nutrition for children 1 to 10 years of age. Fed either by tube or orally, PediaSure can be used as total enteral nutrition support or as a supplement. Indications And Clinical Uses: Enteral nutritional support by tube or by mouth for children 1 to 10 years of age. Support…

PARSITAN® Rh´ne-Poulenc Rorer Ethopropazine HCl Antiparkinsonian Agent Indications And Clinical Uses: Symptomatic treatment of drug induced extrapyramidal manifestations and of Parkinson’s disease of postencephalitic, arteriosclerotic or idiopathic etiology. Contra-Indications: Glaucoma and hypersensitivity to phenothiazine drugs. Precautions: Use with caution in patients with cardiac disease, prostatic hypertrophy or pyloric obstruction. Adverse Reactions: Drowsiness, dizziness, lassitude, blurred vision, dryness of mouth, paresthesia, headache. Very rarely, epigastric distress, confusion and ataxia. Neuroleptic Malignant…

PAS SODIUM General Monograph, CPhA Aminosalicylate Sodium Antimycobacterial Pharmacology: Para-aminosalicylate sodium is the sodium salt of para-aminosalicylic acid (PAS). Note: Aminosalicylate sodium differs from 5-aminosalicylic acid (5-ASA), which is used for the treatment of inflammatory bowel disease. PAS sodium is a highly specific bacteriostatic agent active only against M. tuberculosis. PAS sodium competitively inhibits the formation of dihydrofolic acid from aminobenzoic acid, thus preventing bacterial synthesis of folic acid required…

PATANOL™ Alcon Olopatadine HCl Antiallergy Agent Action And Clinical Pharmacology: Olopatadine is a mast cell stabilizer and a potent, selective histamine H1 antagonist that inhibits the in vivo type 1 immediate hypersensitivity reaction. In vitro studies have demonstrated the ability of olopatadine to stabilize rodent basophils and human conjunctival mast cells and inhibit antigen-stimulated release of histamine. In addition, olopatadine inhibits the release of other mast cell inflammatory mediators (i.e.,…

PARAPLATIN-AQ Bristol Carboplatin Antineoplastic Action And Clinical Pharmacology: Carboplatin has biochemical properties similar to that of cisplatin, thus producing predominantly interstrand DNA crosslinks. In patients with creatinine clearances of 60 mL/min or greater given carboplatin at doses of 300 to 500 mg/m the plasma concentrations of carboplatin decay in a biphasic manner with mean alpha and beta half-lives of 1.6 h and 3 h, respectively. The total body clearance, apparent…

PARLODEL® Novartis Pharmaceuticals Bromocriptine Mesylate Prolactin Inhibitor – Growth Hormone Suppressant in Acromegaly – Adjunctive Medication in Parkinson’s Disease Action And Clinical Pharmacology: Bromocriptine is a dopaminomimetic ergot derivative with D2 type dopamine receptor agonist activity, which also has D1 dopamine receptor antagonist properties. Bromocriptine inhibits the release and synthesis of prolactin by acting directly on the prolactin secreting cells of the anterior pituitary. In patients with acromegaly, in addition…

PARNATE® SmithKline Beecham Tranylcypromine Sulfate Antidepressant Action And Clinical Pharmacology: Tranylcypromine is a nonhydrazine (MAO) inhibitor with a rapid onset of activity. It increases the concentration of epinephrine, norepinephrine and serotonin in storage sites in the nervous system. In theory, the increased concentration of monoamines in the brainstem is the basis for its antidepressant activity. Tranylcypromine differs from other MAO inhibitors in being a reversible inhibitor. When tranylcypromine is withdrawn,…