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TIAZAC® Crystaal Diltiazem HCI Antihypertensive-Antianginal Action and Clinical Uses: Diltiazem is a calcium ion cellular influx inhibitor (calcium entry blocker or calcium ion antagonist).: Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The contractile processes of these tissues are dependent upon the…

TICLID® Roche Ticlopidine HCl Inhibitor of Platelet Function Action and Clinical Uses: Ticlopidine is an inhibitor of platelet aggregation. It causes a time and dose-dependent inhibition of platelet aggregation and release of platelet factors, as well as a prolongation of bleeding time. The drug has no significant in vitro activity. The exact mechanism of action is not fully characterized, but does not involve inhibition of the prostacyclin/thromboxane pathways or platelet…

TILADE® Rh´ne-Poulenc Rorer Nedocromil Sodium Bronchial Anti-inflammatory Agent Action and Clinical Uses: Nedocromil sodium is a new chemical entity that inhibits the release of inflammatory mediators from a variety of cell types occurring in the lumen and in the mucosa of the bronchial tree. When it is administered topically to the bronchi, it displays specific anti-inflammatory properties. Laboratory experiments have shown that nedocromil sodium prevents the release of inflammatory chemotactic…

THYRO-BLOCK® Carter Horner Potassium Iodide Thyroid Blocking Agent Action and Clinical Uses: Potassium iodide, an ionic thyroid blocking agent, acts on the transport of iodide into and out of the thyroid. When given in sufficient amounts, entry of radioiodide into the gland can be virtually prevented. The onset of inhibition is rapid and is readily demonstrated 30 minutes after oral administration. An important factor in obtaining satisfactory acute block of…

THROMBOSTAT™ Parke-Davis Thrombin (Bovine Origin) Topical Hemostatic Action and Clinical Uses: Thrombostat is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin in the presence of calcium chloride. Thrombin requires no intermediate physiological agent for its action. It clots the fibrinogen of the blood directly. Failure to clot blood occurs in the rare case where the primary clotting defect is…

TI-U-LAC® HC Spectropharm Dermatology Hydrocortisone-Urea Topical Corticosteroid Availability And Storage: Each mL of white, odorless, washable lotion contains: hydrocortisone 2.5% and urea 10%. Nonmedicinal ingredients: arlacel, cetyl glycol, Germall, lactic acid, mineral oil, lauryl sulfate, propylene glycol, Veegum, water and white petrolatum. Plastic bottles of 60 mL. Protect from excessive heat. Store at room temperature. Avoid freezing. TI-U-LAC® HC Spectropharm Dermatology Hydrocortisone-Urea Topical Corticosteroid

THYROID HORMONE Parke-Davis Desiccated Thyroid Hypothyroidism Therapy Action and Clinical Uses: The principal pharmacologic effect of exogenous thyroid hormones is to increase the metabolic rate of body tissues. The normal thyroid gland contains approximately 200 g of levothyroxine (T 4)/g of gland, and 15 g of triiodothyronine (T 3)/g. The ratio of these two hormones in the circulation does not represent the ratio in the thyroid gland, since about 80%…

THEOPHYLLINE Technilab Bronchodilator Availability And Storage: Each 15 mL of fruit-flavored elixir contains: theophylline anhydrous 80 mg. Nonmedicinal ingredients: alcohol, artificial coloring and flavorings, FD&C Yellow #6, methylparaben, natural flavoring, propylparaben, purified water, sodium benzoate, sorbitol and sucrose. Bottles of 500 mL. Store between 15 and 30°C. THEOPHYLLINE Technilab Bronchodilator

THROMBATE III® Bayer Antithrombin III (Human) Anticoagulant Action and Clinical Uses: Antithrombin III (AT-III), an alpha 2-glycoprotein of molecular weight 58 000, is normally present in human plasma at a concentration of approximately 12.5 mg/dL and is the major plasma inhibitor of thrombin. Inactivation of thrombin by AT-III occurs by formation of a covalent bond resulting in an inactive 1:1 stoichiometric complex between the two, involving an interaction of the active serine…

THEOCHRON® SR Riva Theophylline Bronchodilator Action and Clinical Theophylline is a bronchodilator which directly relaxes the smooth muscle of the bronchial airways and pulmonary and coronary blood vessels. These actions may be mediated through inhibition of phosphodiesterase and a resultant increase in intracellular cyclic AMP. Theophylline sustained release tablets produce peak blood levels of theophylline between 5 and 8 hours following dosing in adults. Once a steady state level has…