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CERUBIDINE® Rh´ne-Poulenc Rorer Daunorubicin Antimitotic – Antibiotic Action And Clinical Pharmacology: Daunorubicin inhibits the synthesis of nucleic acids; its effect on desoxyribonucleic acid is particularly rapid and marked. Ribonucleic acid is more gradually affected. It appears that the action of the drug is the result of the formation of a complex with desoxyribonucleic acid in the cell nucleus; this blocks the site of action of the polymerases and gives daunorubicin…

CELESTONE® SOLUSPAN ® Schering Betamethasone Sodium Phosphate – Betamethasone Acetate Injectable Glucocorticoid Indications And Clinical Uses: (1) I.M. injection in allergic, dermatologic, rheumatic, and other conditions responsive to systemic corticosteroids, including bursitis; (2) injection directly into the affected tissues in bursitis and associated inflammatory disorders of tendons such as tenosynovitis, and inflammatory disorders of muscle such as fibrositis and myositis; (3) intra-articular and periarticular injection in rheumatoid arthritis and osteoarthritis;…

CellCept® Roche Mycophenolate Mofetil Immunosuppressant Agent Manufacturers’ Warnings In Clinical States: Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. Only physicians experienced in immunosuppressive therapy and management of solid organ transplant patients should use mycophenolate mofetil. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete…

CENTRUM® CENTRUM® FORTE CENTRUM® PROTEGRA CENTRUM® SELECT Whitehall-Robins Multiple Vitamins – Minerals Vitamin-Mineral Supplement Indications And Clinical Uses: For use as a nutritional supplement. Contra-Indications: In the presence of hemochromatosis, hemosiderosis, hemolytic anemia. Precautions: Oral iron preparations may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Oral iron preparations can impair the absorption of tetracycline antibiotics. Antacids given concomitantly with iron compounds decrease iron absorption. Adverse Reactions: Rarely, in…

CEFZIL™ Bristol-Myers Squibb Cefprozil Antibiotic Action And Clinical Pharmacology: Cefprozil is a semisynthetic broad spectrum cephalosporin antibiotic intended for oral administration. It has in vitro activity against a broad range of gram positive and gram negative bacteria. The bactericidal action of cefprozil results from inhibition of cell-wall synthesis. Pharmacokinetics: Cefprozil is well absorbed following oral administration in both fasting and nonfasting subjects. The oral bioavailability of cefprozil is about 90%….

CELESTODERM®-V CELESTODERM®-V/2 Schering Betamethasone Valerate Topical Corticosteroid Indications And Clinical Uses: The topical management of allergic and inflammatory dermatoses responsive to corticosteroid therapy, such as psoriasis, atopic eczema, infantile eczema, nummular eczema, pruritus ani and vulvae, neurodermatitis (lichen simplex chronicus), intertrigo, contact dermatitis, seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis and dyshidrosis. Refractory psoriasis may be treated with Celestoderm-V especially in conjunction with the hydration technique of occlusive dressings….

CELESTONE® Schering Betamethasone Glucocorticoid Indications And Clinical Uses: Betamethasone is used orally in the management of disorders responsive to adrenocortical hormone therapy such as: Endocrine Disorders: primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; nonsuppurative thyroiditis; hypercalcemia associated with cancer. Musculoskeletal Disorders: as adjunctive…

CEFAZOLIN SODIUM USP Novopharm Antibiotic Action And Clinical Pharmacology: Cefazolin is a cephalosporin antibiotic for parenteral administration. Cefazolin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. Cefazolin is about 85% bound to serum protein. The peak level in serum is approximately 32 to 42 mg/mL after an i.m. injection of 500 mg. Over 80% of injected cefazolin is excreted in the urine during the first 24 hours after…

CeeNU® Bristol Lomustine Antineoplastic Agent Action And Clinical Pharmacology: It is generally agreed that lomustine acts as an alkylating agent but, as with other nitrosoureas, it may also inhibit several key enzymatic processes. Lomustine may be given orally. Following oral administration of radioactive lomustine at doses ranging from 30 mg/mto 100 mg/m about half of the radioactivity given was excreted within 24 hours. The serum half-life of the drug and/or…

CEFOTAN® Wyeth-Ayerst Cefotetan Disodium Antibiotic Action And Clinical Pharmacology: Cefotetan disodium is a semisynthetic, beta-lactamase resistant, cephalosporin (cephamycin) antibiotic. In vitro studies indicate that the bactericidal action of cefotetan results from an interference of bacterial cell wall synthesis by inhibiting the cross-linking of peptidoglycan. Studies with 4-labeled cefotetan have shown that on reaching the target penicillin-binding proteins (PBPs) in the inner membrane, the radiolabeled antibiotic binds principally to PBP 3…