You searched for : 'U'

ZOVIRAX® Cream Glaxo Wellcome Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate…

ZYPREXA® Lilly Olanzapine Antipsychotic Action And Clinical Pharmacology: Pharmacodynamics: Olanzapine, a thienobenzodiazepine, is an antipsychotic agent, displaying high receptor affinity binding in vitro at serotonin 5-HT2A/C (Ki=4 and 11 nM, respectively), dopamine D1, D2, D3, D4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9 to 2.5 nM), adrenergic a1(Ki=19 nM), and histamine H1 (Ki=7 nM) receptors. In a behavioral paradigm predictive of antipsychotic activity, olanzapine reduced conditioned avoidance response in rats…

ZOSTRIX® H.P. Medicis Capsaicin Neuralgia Therapy Action And Clinical Pharmacology: Current evidence suggests that capsaicin works by its action on a pain transmitting compound called substance P. Capsaicin causes substance P to leave the nerve endings. With a lower amount of substance P in the nerve endings, pain impulses cannot be transmitted to the brain. Indications: For the relief of neuralgias (pain from nerves near the surface of the skin)…

ZOSTRIX® Medicis Capsaicin Neuralgia Therapy Action And Clinical Pharmacology: Although the precise mechanism of action of capsaicin is not fully understood, current evidence suggests that capsaicin renders skin insensitive to pain by depleting and preventing reaccumulation of substance P in peripheral sensory neurons. Substance P is thought to be the principal chemomediator of pain impulses from the periphery to the CNS. Indications: For the temporary relief of the pain (neuralgia)…

ZOVIRAX® Ointment Glaxo Wellcome Acyclovir Antiviral Agent Action And Clinical Pharmacology: Acyclovir, an acyclic nucleoside analog, is a substrate specific for herpesvirus-specified thymidine kinase. It inhibits replication of these viruses. Normal cellular thymidine kinase does not effectively utilize acyclovir as a substrate. Herpes-virus-specified thymidine kinase transforms acyclovir to its monophosphate which is then transformed by cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. Acyclovir triphosphate is both an inhibitor of,…

ZOLADEX® LA Zeneca Goserelin Acetate Luteinizing Hormone-Releasing Hormone Analog (LHRH Analog) Action And Clinical Pharmacology: Goserelin is a synthetic decapeptide analog of gonadotropin releasing hormone (GnRH or LHRH). When given acutely, goserelin stimulates the release of pituitary luteinizing hormone (LH) from the pituitary gland. However, following chronic administration, goserelin is a potent inhibitor of gonadotropin production resulting in gonadal and consequently, accessory sex organ regression. This effect is the basis…

ZOLADEX® Zeneca Goserelin Acetate LHRH Analog Action And Clinical Pharmacology: Goserelin is a synthetic decapeptide analog of gonadotropin releasing hormone (GnRH or LHRH). When given acutely, goserelin releases luteinizing hormone (LH) from the pituitary gland. However, following chronic administration, goserelin is a potent inhibitor of gonadotropin production resulting in gonadal and consequently, accessory sex organ regression. This effect is the basis for the inhibition of growth of chemically-induced rat mammary…

ZOLOFT™ Pfizer Sertraline HCl Antidepressant – Antipanic – Antiobsessional Agent Action And Clinical Pharmacology: The mechanism of action of sertraline is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets. Like most clinically effective antidepressants, sertraline downregulates brain norepinephrine and serotonin…

ZONALON Medicis Doxepin HCl Antipruritic Agent Action And Clinical Pharmacology: Doxepin, a dibenzoxepin-derivative tricyclic compound, is a topical antipruritic. While the exact mechanism of antipruritic activity is unknown, doxepin exhibits potent histamine H1 and H2 receptor antagonist activity. Although the sedative effect of systemically absorbed doxepin may contribute to the drug’s antipruritic activity, the antipruritic efficacy of doxepin reportedly does not appear to depend on a sedative effect. tag_IndicationsIndications Indications…

ZITHROMAX™ Pfizer Azithromycin Dihydrate Antibiotic Action And Clinical Pharmacology: Azithromycin, a macrolide antibiotic of the azalide subclass, exerts its antibacterial action by binding to the 50s ribosomal subunits of susceptible bacteria and suppressing protein synthesis. Following oral administration, azithromycin is rapidly absorbed (Tmax = 2 to 3 hours) and distributed widely throughout the body. Rapid movement of azithromycin from blood into tissue results in significantly higher azithromycin concentrations in tissue…