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FASTIN® SmithKline Beecham Phentermine HCl Anorexiant Action And Clinical Pharmacology: Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include CNS stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known…

EX-LAX® Chocolated Pieces EX-LAX® Sugar Coated Pills EX-LAX® Extra Strength Sugar Coated Pills Novartis Consumer Health Sennosides Laxative Action And Clinical Pharmacology: Sennosides are a natural source complex of anthraquinone glycosides found in senna. They exert a stimulant laxative effect that increases peristalsis by direct action on the smooth muscle of the intestine. They generally produce bowel movement in 6 to 12 hours. Indications And Clinical Uses: For the overnight…

EVISTA™ Lilly Raloxifene HCl Selective Estrogen Receptor Modulator Action And Clinical Pharmacology: Raloxifene is a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds. The SERM profile of raloxifene includes estrogen agonist effects on bone and lipid metabolism but not in uterine or breast tissues. Pharmacokinetics: The disposition of raloxifene has been evaluated in 276 postmenopausal women in conventional clinical pharmacology studies and in more than…

FAMVIR™ SmithKline Beecham Famciclovir Antiviral Agent Action And Clinical Pharmacology: Famciclovir is the orally administered pro-drug of the antiviral agent penciclovir. Famciclovir itself has no antiviral activity until it is biotransformed to penciclovir. Following oral administration little or no famciclovir is detected in plasma or urine since famciclovir is rapidly converted via deacetylation and oxidation to penciclovir. Studies in volunteers have shown that famciclovir is well absorbed and produces plasma…

ETRAFON® Preparations Schering Amitriptyline HCl – Perphenazine Antidepressant – Antipsychotic Indications And Clinical Uses: The treatment of patients with anxious or agitated depression. Particularly indicated in patients with depression associated with marked psychomotor unrest and anxiety. Etrafon has also been used in some schizophrenic patients who have associated symptoms of depression and in depressed patients suffering from marked agitation, anxiety and tension, which may respond to a phenothiazine agent. Contraindications,…

ETHYOL® Lilly Amifostine Cytoprotective Agent Action And Clinical Pharmacology: Amifostine is a prodrug that is dephosphorylated to a pharmacologically active metabolite, the free thiol (WR-1065), at the tissue site by membrane-bound alkaline phosphatase. The ability of amifostine to selectively protect normal tissues is based upon the differential metabolism and uptake of the free thiol into normal versus malignant tissues. This differential effect is attributed to the higher capillary alkaline phosphatase…

ETOPOSIDE INJECTION Novopharm Antineoplastic Action And Clinical Pharmacology: Etoposide is a semisynthetic derivative of podophyllotoxin. Etoposide exhibits cytostatic activity in vitro by preventing cells from entering mitosis or by destroying them at a premitotic stage. Etoposide interferes with the synthesis of DNA and appears to arrest human lymphoblastic cells in the late S-G2 phases of the cell cycle. The effects of etoposide on the human hematopoietic system are substantial. The…

ESTRACOMB® Novartis Pharmaceuticals Estradiol-17b – Norethindrone Acetate – Estradiol-17b Estrogen – Progestin Action And Clinical Pharmacology: Estracomb is designed to provide continuous estrogen and sequential progestin therapy, in a 28-day treatment cycle, for women with an intact uterus. Estracomb contains 2 types of transdermal therapeutic systems, Estraderm 50 (10 cm and Estragest 250/50 (20 cm. Estraderm 50 contains estradiol-17b and Estragest 250/50 contains norethindrone acetate (NETA) and estradiol-17b, respectively. Both…

ESTRACE® Roberts Estradiol-17b (micronized) Estrogen Action And Clinical Pharmacology: Estrogens are secreted mainly by the gonads and, to a very small amount, by the adrenals. In addition, they are formed, to an important degree, from peripheral conversion of adrenal and gonadal androgens to estrogens. They circulate in both unconjugated and conjugated forms in the blood, with the unconjugated estrogens, either free or bound to proteins, mainly albumin, or to the…

ESTRADERM® Novartis Pharmaceuticals Estradiol-17b Estrogen Description: Estraderm is a thin, round, multilayer, transparent transdermal therapeutic system, i.e., an adhesive patch, containing estradiol-17b that is designed for application to an area of intact skin. The Estraderm patch comprises 5 layers. Proceeding from the visible surface toward the surface attached to the skin, these layers are: 1. a transparent polyester backing film; 2. a drug reservoir of estradiol-17b and ethanol gelled with…