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THIOTEPA Wyeth-Ayerst Cytotoxic Agent Action and Clinical Uses: Thiotepa is a cytotoxic agent of the polyfunctional alkylating type (more than one reactive ethylenimine group) related chemically and pharmacologically to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principal bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs…

THROMBATE III® Bayer Antithrombin III (Human) Anticoagulant Action and Clinical Uses: Antithrombin III (AT-III), an alpha 2-glycoprotein of molecular weight 58 000, is normally present in human plasma at a concentration of approximately 12.5 mg/dL and is the major plasma inhibitor of thrombin. Inactivation of thrombin by AT-III occurs by formation of a covalent bond resulting in an inactive 1:1 stoichiometric complex between the two, involving an interaction of the active serine…

THEOCHRON® SR Riva Theophylline Bronchodilator Action and Clinical Theophylline is a bronchodilator which directly relaxes the smooth muscle of the bronchial airways and pulmonary and coronary blood vessels. These actions may be mediated through inhibition of phosphodiesterase and a resultant increase in intracellular cyclic AMP. Theophylline sustained release tablets produce peak blood levels of theophylline between 5 and 8 hours following dosing in adults. Once a steady state level has…

THEOLAIR™-SR 3M Pharmaceuticals Theophylline Bronchodilator Availability And Storage: 250 mg: Each white, round, sustained-release tablet, “3M” imprint on one face, “SR-250” bisect score on the other face, contains: theophylline (anhydrous) 250 mg. Nonmedicinal ingredients: cellulose acetate phthalate, lactose and magnesium stearate. Tartrazine-free. Bottles of 100. 300 mg: Each white, oval-shaped, sustained-release tablet, “3M” imprint on one face, “SR-300” bisect bar on the other face, contains: theophylline (anhydrous) 300 mg. Nonmedicinal…

THEOLAIR™ 3M Pharmaceuticals Theophylline Bronchodilator Availability And Storage: Liquid: Each 15 mL of alcohol free, citrus berry flavored liquid contains: theophylline (anhydrous) 80 mg. Nonmedicinal ingredients: flavor, methyl- and propylparabens, purified water, sorbitol and sucrose. Tartrazine-free. Bottles of 500 mL. Tablets: 125 mg: Each white, round tablet, “3M” imprint on one face, “342” bisect score on the other face contains: theophylline (anhydrous) 125 mg. Nonmedicinal ingredients: colloidal silicon dioxide, lactose,…

THEO-BRONC® Rougier Pharma Theophylline–Potassium Iodide–Guaifenesin–Mepyramine Maleate Bronchodilator–Expectorant Indications And Clinical Uses: For the symptomatic relief of reversible bronchoconstriction associated with chronic obstructive pulmonary emphysema, bronchial asthma, chronic bronchitis and related bronchospastic disorders and where expectoration is required. Contra-Indications: Hyperthyroidism, active peptic ulcer, sensitivity to any of the components, pregnancy, in coronary artery disease where myocardial stimulation might prove harmful. Precautions: Inquire before administration, particularly in young children (less than 7…

THEO-DUR® AstraZeneca Theophylline Bronchodilator Action and Clinical Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels to relieve bronchospasm and increase flow rates and vital capacity. It also produces other actions typical of the xanthine derivatives: coronary vasodilation, diuresis, increase in gastric secretion, and cardiac, cerebral, and skeletal muscle stimulation. The actions of theophylline may be mediated through inhibition of phosphodiesterase and a resultant increase in…

TERSASEPTIC® TCD Triclosan Antibacterial Cleanser Availability And Storage: Each 150 or 450 mL bottle contains: triclosan 0.5% in a liquid soapless detergent anionic base and emollients. Nonmedicinal ingredients: citric acid anhydrous, diethanolamine alcohol sulfate, diethylene glycol and ethylene glycol, EDTA, FD&C yellow, fragrance, lauramide and propylene glycol and PEG 6000 distearate. Preservative-free. pH 6.5. TERSASEPTIC® TCD Triclosan Antibacterial Cleanser

TERAZOL® Janssen-Ortho Terconazole Antifungal Action and Clinical The exact pharmacologic mode of action of terconazole is uncertain; however, it may exert its antifungal activity by disruption of normal fungal cell membrane permeability. Terconazole exhibits fungicidal activity in vitro against the genus Candida. Both the yeast and mycelial forms of C. albicans are sensitive to terconazole. Following intravaginal administration of terconazole in humans, absorption ranged from 5 to 8% in 3…

TERSAC® TCD Salicylic Acid–Triclosan Acne Therapy Availability And Storage: Each 120 g tube contains: salicylic acid USP 2% and triclosan 0.5% in an aqueous lathering gel base. Nonmedicinal ingredients: cocamido propyl betaine, coco betaine, glycerin, methylparaben, purified water, salicylic acid, sodium laureth sulfate, sodium metabisulfite, tetra sodium EDTA and triclosan. TERSAC® TCD Salicylic Acid–Triclosan Acne Therapy