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NORINYL® 1/50 Searle Norethindrone – Mestranol Oral Contraceptive Action And Clinical Pharmacology: Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness. Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic…

NORITATE® Dermik Laboratories Canada Metronidazole Antirosacea Agent Action And Clinical Pharmacology: Metronidazole topical cream is particularly effective against the inflammatory papulopustular component of rosacea. The mechanisms by which metronidazole act in reducing inflammatory lesions of rosacea are unknown, but may include an antibacterial and/or an anti-inflammatory effect. Indications And Clinical Uses: For topical application in the treatment of inflammatory papules, pustules and erythema of rosacea. Contra-Indications: In individuals with a…

NORLUTATE® Parke-Davis Norethindrone Acetate Progestational Agent Action And Clinical Pharmacology: Norethindrone acetate differs from norethindrone only in potency; the acetate is approximately twice as potent. Transforms proliferative endometrium into secretory endometrium. Inhibits (at the usual dose range) the secretion of pituitary gonadotropins, which in turn prevents follicular maturation and ovulation. May also demonstrate some estrogenic, anabolic or androgenic activity but should not be relied upon. Indications And Clinical Uses: Amenorrhea;…

NORFLEX™ 3M Pharmaceuticals Orphenadrine Citrate Skeletal Muscle Relaxant Action And Clinical Pharmacology: The mode of therapeutic action has not been clearly identified but may be related to its analgesic properties. Orphenadrine citrate also possesses anticholinergic actions. Norflex is an extended release formulation that gives a peak level of 60 ng/mL at 8 hours following a 100 mg dose, as opposed to an immediate release product that gives a peak of…

NORCURON® Organon Vecuronium Bromide Nondepolarizing Neuromuscular Blocking Agent Action And Clinical Pharmacology: Vecuronium is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic curariform pharmacological actions of this class of drugs. It acts by competing for cholinergic receptors at the motor end-plate. The antagonism to acetylcholine is inhibited and neuromuscular block is reversed by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine. Vecuronium is about a third more potent…

NIX® Dermal Cream Glaxo Wellcome Permethrin Topical Scabicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, which is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance. Lag…

NIX® Creme Rinse Warner-Lambert Consumer Healthcare Permethrin Topical Pediculicide – Ovicide Action And Clinical Pharmacology: Permethrin is a synthetic pyrethroid, active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance….

NIZORAL® Shampoo McNeil Consumer Products Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and…

NIZORAL® Tablets Janssen-Ortho Ketoconazole Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma membrane….

NIZORAL® Cream Janssen-Ortho Ketoconazole Topical Antifungal Action And Clinical Pharmacology: In vitro studies suggest that the antifungal properties of ketoconazole may be related to its ability to impair the synthesis of ergosterol, a component of fungal and yeast cell membranes. Without the availability of this essential sterol, there are morphological alterations of the fungal and yeast cell membranes manifested as abnormal membranous inclusions between the cell wall and the plasma…