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WELLBUTRIN® SR Glaxo Wellcome Bupropion HCl Antidepressant Action And Clinical Pharmacology: Bupropion is an antidepressant of the aminoketone class. It is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitors or other known antidepressant agents. Its structure closely resembles that of diethylpropion. It is related to the phenylethylamines. The mechanism of bupropion’s antidepressant activity is unknown but appears to be mediated by noradrenergic (and possibly dopaminergic), rather than serotonergic mechanisms….

VOLTAREN® Novartis Pharmaceuticals Diclofenac Sodium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. The mode of action is not fully known but it does not act through the pituitary-adrenal axis. Diclofenac inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. This inhibitory effect may partially explain its actions. From a clinical efficacy standpoint, diclofenac sodium 75…

VUMON® PARENTERAL Bristol Teniposide Antineoplastic Action And Clinical Pharmacology: Teniposide is a semi-synthetic derivative of podophyllotoxin. In vitro, teniposide exerts a powerful cytostatic effect by first arresting cells in metaphase. Its main effect, however, is preventing cells from entering mitosis (arrest of G2 phase of cell cycle) within 1 to 2 hours after drug addition. At higher concentrations, a third effect can be observed, disintegration of part of interphase cells…

WARTEC® Pharmascience Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is a metaphase inhibitor of dividing cells. Podofilox binds to at least one binding site on tubulin. This binding prevents the tubulin polymerization required for microtubule assembly. At higher concentrations podofilox also inhibits nucleoside transport through the cell membrane. The…

WARFILONE® Frosst Warfarin Sodium Oral Anticoagulant Indications And Clinical Uses: The prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, heart valve prosthesis and acute peripheral arterial embolism. Also in the prophylaxis and treatment of pulmonary embolism. In acute myocardial infarction for patients with high risk factors for thromboembolic complications and as an adjunct in the treatment of coronary occlusion. It is also…

VIVOTIF BERNA™ Berna Products Typhoid Vaccine Live Oral Attenuated Ty21a Typhoid Prophylaxis Action And Clinical Pharmacology: S. typhi is the etiological agent of typhoid fever, an acute, febrile enteric disease. This vaccine will not afford protection against species of Salmonella other than S. typhi or other bacteria that cause enteric disease. The incidence of typhoid fever has declined steadily in Canada. Approximately 70 cases are reported annually. Many of these…

VIVOTIF BERNA® L VACCINE Berna Products Typhoid Vaccine Live Oral Attenuated Ty21a Typhoid Prophylaxis Action And Clinical Pharmacology: S. typhi is the etiological agent of typhoid fever, an acute, febrile enteric disease. This vaccine will not afford protection against species of Salmonella other than S. typhi or other bacteria that cause enteric disease. The incidence of typhoid fever has declined steadily in Canada. Approximately 70 cases are reported annually. Most…

VOLTAREN OPHTHA® CIBA Vision Diclofenac Sodium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Diclofenac is a nonsteroidal anti-inflammatory drug with analgesic properties. The mode of action is not fully known, but it does not act through the pituitary-adrenal axis, even when given systemically. Diclofenac inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. Prostaglandins play a critical role in many inflammatory processes of the eye and appear to…

VOLTAREN RAPIDE® Novartis Pharmaceuticals Diclofenac Potassium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Diclofenac potassium, the active substance of Voltaren Rapide is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. This inhibitory effect may partially explain its actions. It is considered to be a peripherally acting analgesic. Diclofenac potassium tablets have a rapid onset of action,…

VIVELLE® Novartis Pharmaceuticals Estradiol-17b Estrogen Description: Vivelle is a thin, circular, multilayer, transparent transdermal therapeutic system, i.e., an adhesive patch, containing estradiol-17b that is designed for application to an area of intact skin. The Vivelle patch comprises 3 layers. Proceeding from the visible surface toward the surface attached to the skin, these layers are: 1. A flexible semi-transparent backing film of polyurethane and ethylene vinyl alcohol polymer. 2. An adhesive…