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BACTROBAN® SmithKline Beecham Mupirocin Topical Antibiotic Action And Clinical Pharmacology: Mupirocin exerts a bactericidal action against sensitive organisms by inhibiting bacterial protein synthesis. It reversibly and specifically binds to bacterial isoleucyl transfer-RNA synthetase Indications And Clinical Uses: For the topical treatment of the following when caused by sensitive strains of staphylococcus and streptococcus species: impetigo, superficially infected dermatoses, lesions which are moist and weeping. For abrasions, minor cuts and wounds,…

BACTRIM™ ROCHE® Roche Trimethoprim – Sulfamethoxazole Antibacterial Action And Clinical Pharmacology: Trimethoprim plus sulfamethoxazole block 2 consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria. Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by reversibly inhibiting the required enzyme, dihydrofolate reductase. The effect of the dual consecutive action is to reduce…

BARBITURATES Amobarbital Butabarbital Pentobarbital Phenobarbital Secobarbital Anticonvulsant – Sedative-Hypnotic Pharmacology: Barbiturates are nonselective central nervous system (CNS) depressants, capable of producing all degrees of depression from mild sedation and hypnosis to general anaesthesia, deep coma and death. The extent of CNS depression varies with the route of administration, dose and pharmacokinetic characteristics of the particular barbiturate. Patient specific factors such as age, physical or emotional state and the concomitant use…

BARRIERE-HC® Roberts Hydrocortisone – Silicone Dermatitis Therapy Indications And Clinical Uses: Adjunctive treatment of allergic dermatoses and other inflammatory skin conditions amenable to topical corticosteroid therapy (e.g., contact, atopic and seborrheic dermatitis, neurodermatitis, psoriasis and anogenital pruritus). Contra-Indications: Tuberculous and most fungal and viral lesions of the skin, herpes simplex, vaccinia and varicella particularly. Precautions: Although untoward effects associated with the use of topical corticosteroids are uncommon and not to…

BAYCOL® Bayer Cerivastatin Sodium Lipid Metabolism Regulator Action And Clinical Pharmacology: Cerivastatin is an entirely synthetic, enantiomerically pure cholesterol-lowering agent and is structurally similar to the fungal derivatives of this therapeutic class. Cerivastatin is a competitive inhibitor of 3-hydroxy-3methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol. The inhibition of cholesterol biosynthesis by cerivastatin…

BCG Vaccine (Freeze Dried) Connaught Attenuated Tubercle Bacillus Active Immunizing Agent Action And Clinical Pharmacology: BCG Vaccine (Freeze-Dried) for intracutaneous administration, as prepared by Connaught Laboratories Limited, is made from a culture of an attenuated strain of living bovine tubercle bacillus (Bacillus Calmette-Gurin). It is supplied as a freeze-dried product ready for immediate use following reconstitution with the accompanying diluent, which consists of sterile phosphate-buffered saline. The manufacturing and testing…

BACTIGRAS® Smith & Nephew Chlorhexidine Acetate Topical Antibacterial Action And Clinical Pharmacology: Chlorhexidine inhibits the growth of vegetative gram-positive and gram-negative organisms in vitro. Acid fast bacilli and heat resistant bacterial spores are not susceptible to the lethal action of chlorhexidine even in strong concentrations at room temperature. Chlorhexidine has greater activity in alkaline media. Adsorption of chlorhexidine on organic matter, pus, serum, blood, etc. will cause a reduction in…

BACITRACIN Pharmacia & Upjohn Antibiotic Action And Clinical Pharmacology: Bacitracin, an antibiotic substance derived from cultures of B. subtilis (Tracey), exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy. Bacitracin is assayed against a standard and its activity is expressed in units, 1 mg having a potency of not less…

BABY’S OWN™ INFANT DROPS Block Drug Simethicone Antiflatulent Indications And Clinical Uses: To relieve infant colic, bloating and flatulence due to gas. Warnings: Keep this and all drugs out of the reach of children. Do not take for more than 2 weeks unless directed by a physician. If symptoms recur consult a physician. Dosage: Shake well before using. Use only on the advice of a physician. Infants (under 2 years):…

BABY’S OWN™ TEETHING GEL Block Drug Benzyl Alcohol Topical Analgesic Indications And Clinical Uses: For quick relief from teething pain by its topical anesthetic effect on sore gums. Warnings: Keep this and all medications out of the reach of children. Dosage: Wash hands. Apply small amount directly to sore gums. Repeat, if necessary, every 4 hours. If symptoms persist, consult physician. Availability And Storage: Each pleasantly flavored g of gel…