Bactroban (Mupirocin)

BACTROBAN®

SmithKline Beecham

Mupirocin

Topical Antibiotic

Action And Clinical Pharmacology: Mupirocin exerts a bactericidal action against sensitive organisms by inhibiting bacterial protein synthesis. It reversibly and specifically binds to bacterial isoleucyl transfer-RNA synthetase

Indications And Clinical Uses: For the topical treatment of the following when caused by sensitive strains of staphylococcus and streptococcus species: impetigo, superficially infected dermatoses, lesions which are moist and weeping.

For abrasions, minor cuts and wounds, the use of mupirocin may prevent the development of infection by sensitive Gram-positive organisms.

No cross-resistance has been shown between mupirocin and other commonly used antibiotics.

Contra-Indications: In patients with a history of hypersensitivity to mupirocin or to other ointments containing polyethylene glycols.

Manufacturers’ Warnings In Clinical States: This mupirocin ointment formulation is not suitable for ophthalmic or intranasal use, or in conjunction with cannulae.

When mupirocin ointment is used on the face, care should be taken to avoid the eyes.

Polyethylene glycol (PEG) can be absorbed from open wounds and damaged skin. It is excreted by the kidneys. As with other PEG based ointments, mupirocin ointment should not be used in conditions where absorption of large quantities of PEG is possible, especially if there is evidence of moderate or severe renal impairment.

In the rare event of a possible sensitization reaction or severe local irritation occurring with the use of mupirocin, treatment should be discontinued and appropriate alternative therapy for the infection instituted.

Precautions: Use of topical antibiotics occasionally allows overgrowth of non-susceptible organisms. If this occurs, or irritation or sensitization develop, treatment should be discontinued and appropriate therapy instituted.

Pregnancy and Lactation: Safety in the treatment of infections during pregnancy has not been established. If administration to pregnant patients is considered necessary, its potential benefits should be weighed against the possible hazards to the fetus. Caution should be exercised when mupirocin ointment is administered to nursing mothers.

If a cracked nipple is to be treated, lactation from the affected breast should be maintained by manual expression until the end of treatment. During this time, milk from the affected breast should be discarded.

Adverse Reactions: The following local adverse reactions have been reported during therapy with mupirocin: itching, burning, erythema, stinging and dryness. It was not usually necessary to discontinue therapy due to these adverse reactions. Cutaneous sensitization reactions to mupirocin or the ointment base have been reported rarely.

Symptoms And Treatment Of Overdose: Symptoms and Treatment: Overdosage has not been known to occur during topical therapy with mupirocin ointment.

Dosage: A small amount of the ointment should be applied to the affected area 3 times daily for up to 10 days, depending on the response. The area treated may be covered with a gauze dressing if desired.

Availability And Storage: Each g of ointment contains: mupirocin 20 mg (2%) in a bland water-soluble ointment base consisting of polyethylene glycol 400 and polyethylene glycol 3 350 (polyethylene glycol ointment, USP). Tubes of 15 and 30 g. Store at room temperature.

BACTROBAN® SmithKline Beecham Mupirocin Topical Antibiotic

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