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CellCept® Roche Mycophenolate Mofetil Immunosuppressant Agent Manufacturers’ Warnings In Clinical States: Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. Only physicians experienced in immunosuppressive therapy and management of solid organ transplant patients should use mycophenolate mofetil. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete…

CELONTIN® Parke-Davis Methsuximide Anticonvulsant Action And Clinical Pharmacology: Methsuximide elevates seizure threshold in the cortex and basal ganglia and reduces synaptic response to low frequency repetitive stimulation. The peroxisomal spike and wave pattern of the EEG, common in petit mal seizure, is suppressed. Pharmacokinetics: Methsuximide is absorbed from the gastrointestinal tract and peak plasma levels are achieved in 1 to 3 hours. The plasma half-life of methsuximide is slightly less…

CEFTIN® Glaxo Wellcome Cefuroxime Axetil Antibiotic Action And Clinical Pharmacology: Cefuroxime axetil is an orally active prodrug of cefuroxime. After oral administration, cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release cefuroxime into the blood stream. Conversion to cefuroxime, the microbiologically active form, occurs rapidly. The inherent properties of cefuroxime are unaltered after its administration as cefuroxime…

CEFZIL™ Bristol-Myers Squibb Cefprozil Antibiotic Action And Clinical Pharmacology: Cefprozil is a semisynthetic broad spectrum cephalosporin antibiotic intended for oral administration. It has in vitro activity against a broad range of gram positive and gram negative bacteria. The bactericidal action of cefprozil results from inhibition of cell-wall synthesis. Pharmacokinetics: Cefprozil is well absorbed following oral administration in both fasting and nonfasting subjects. The oral bioavailability of cefprozil is about 90%….

CELESTODERM®-V CELESTODERM®-V/2 Schering Betamethasone Valerate Topical Corticosteroid Indications And Clinical Uses: The topical management of allergic and inflammatory dermatoses responsive to corticosteroid therapy, such as psoriasis, atopic eczema, infantile eczema, nummular eczema, pruritus ani and vulvae, neurodermatitis (lichen simplex chronicus), intertrigo, contact dermatitis, seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis and dyshidrosis. Refractory psoriasis may be treated with Celestoderm-V especially in conjunction with the hydration technique of occlusive dressings….

CELESTONE® Schering Betamethasone Glucocorticoid Indications And Clinical Uses: Betamethasone is used orally in the management of disorders responsive to adrenocortical hormone therapy such as: Endocrine Disorders: primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; nonsuppurative thyroiditis; hypercalcemia associated with cancer. Musculoskeletal Disorders: as adjunctive…

CEFAZOLIN SODIUM USP Novopharm Antibiotic Action And Clinical Pharmacology: Cefazolin is a cephalosporin antibiotic for parenteral administration. Cefazolin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. Cefazolin is about 85% bound to serum protein. The peak level in serum is approximately 32 to 42 mg/mL after an i.m. injection of 500 mg. Over 80% of injected cefazolin is excreted in the urine during the first 24 hours after…

CeeNU® Bristol Lomustine Antineoplastic Agent Action And Clinical Pharmacology: It is generally agreed that lomustine acts as an alkylating agent but, as with other nitrosoureas, it may also inhibit several key enzymatic processes. Lomustine may be given orally. Following oral administration of radioactive lomustine at doses ranging from 30 mg/mto 100 mg/m about half of the radioactivity given was excreted within 24 hours. The serum half-life of the drug and/or…

CEFIZOX® SmithKline Beecham Ceftizoxime Sodium Antibiotic Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftizoxime results from inhibition of cell-wall synthesis in aerobic and anaerobic gram-positive and gram-negative organisms. In vitro, ceftizoxime shows a strong affinity for penicillin-binding proteins 1a, 1bs and 3 of E. coli. Indications And Clinical Uses: In the treatment of the infections listed below when caused by susceptible strains of the…

CEFOTAN® Wyeth-Ayerst Cefotetan Disodium Antibiotic Action And Clinical Pharmacology: Cefotetan disodium is a semisynthetic, beta-lactamase resistant, cephalosporin (cephamycin) antibiotic. In vitro studies indicate that the bactericidal action of cefotetan results from an interference of bacterial cell wall synthesis by inhibiting the cross-linking of peptidoglycan. Studies with 4-labeled cefotetan have shown that on reaching the target penicillin-binding proteins (PBPs) in the inner membrane, the radiolabeled antibiotic binds principally to PBP 3…