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COMBIVENT® Inhalation Aerosol Boehringer Ingelheim Ipratropium Bromide – Salbutamol Sulfate Bronchodilator Action And Clinical Pharmacology: Combivent Inhalation Aerosol is a combination of the anticholinergic bronchodilator, ipratropium bromide, and the b2-adrenergic bronchodilator, salbutamol sulfate. Each actuation from the valve delivers 20 µg ipratropium bromide and 120 µg salbutamol sulfate (equivalent to 100 µg salbutamol base). Ipratropium bromide is a quaternary ammonium derivative of atropine and is an anticholinergic with bronchodilator properties….

Colchicine (Oral) General Monograph, Gout Therapy Action And Clinical Pharmacology: Although its exact mode of action in the relief of gout is not completely understood, colchicine is known to decrease the inflammatory response to urate crystal deposition by inhibiting migration of leukocytes, to interfere with urate deposition by decreasing lactic acid production by leukocytes, to interfere with kinin formation and to diminish phagocytosis and the subsequent anti-inflammatory response. The anti-inflammatory…

COLACE® Roberts Docusate Sodium Stool Softener Indications And Clinical Uses: The management of constipation due to hard stools, in painful anorectal conditions, in cardiac and other conditions in which maximum ease of passage is desirable to avoid difficult or painful defecation, and when peristaltic stimulants are contraindicated. Contra-Indications: Presence of abdominal pain, nausea or vomiting. Precautions: Do not administer concomitantly with mineral oil: increased absorption of the oil may result….

COLESTID® Pharmacia & Upjohn Colestipol HCl Oral Antihypercholesterolemic Action And Clinical Pharmacology: Colestipol is hygroscopic, water insoluble, and it is neither hydrolyzed by digestive enzymes nor is it absorbed. Colestipol binds with bile acids in the intestine forming a complex that is excreted in the feces. This non-systemic action results in a continuous, partial removal of bile acids from the enterohepatic circulation preventing their reabsorption. This increased fecal loss of…

COLPERMIN™ R & C Peppermint Oil Symptomatic Relief of Irritable Bowel Syndrome Action And Clinical Pharmacology: The mechanism of action of peppermint oil or its major component, menthol, in reducing lower bowel motility has not been completely elucidated. It has been postulated that peppermint oil exerts its gastrointestinal smooth muscle inhibitory effect by altering calcium ion transport. Using intraluminal pressure recordings and ultrasound measurements of colonic activity it has been…

COATED ASPIRIN® Bayer Consumer ASA Analgesic – Anti-inflammatory – Antipyretic Indications And Clinical Uses: 80 mg: For use in children only for rheumatic and arthritic pain under the supervision of a physician. Do not use to treat fever. 325 mg/500 mg/650 mg: For the temporary relief of arthritic and rheumatic pain, muscle aches, joint pain and back pain. Coated Aspirin has a special enteric coating recommended by doctors to help…

CoACTIFED® Preparations Glaxo Wellcome Triprolidine HCl – Codeine Phosphate – Pseudoephedrine HCl Antihistamine – Antitussive – Decongestant Indications And Clinical Uses: CoActifed Expectorant: To facilitate expectoration and control cough associated with inflamed mucosa and tenacious sputum. CoActifed Syrup and Tablets: The treatment of cough associated with inflamed mucosa. Contra-Indications: This drug should not be used in newborn or premature infants. Hypersensitivity to codeine phosphate or other narcotics, triprolidine hydrochloride, or…

CODEINE CONTIN® Purdue Frederick Codeine Monohydrate – Codeine Sulfate Trihydrate Opioid Analgesic Action And Clinical Pharmacology: Codeine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, codeine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and…

COGENTIN® MSD Benztropine Mesylate Antiparkinsonian Agent Action And Clinical Pharmacology: Benztropine is a synthetic compound resulting from the combination of the active portions of atropine and diphenhydramine. Benztropine possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism. Benztropine antagonizes the effect of acetylcholine. This decreases the imbalance between the neurotransmitters, acetylcholine and dopamine, which may improve the symptoms…

CLOPIXOL® CLOPIXOL-ACUPHASE® CLOPIXOL® DEPOT Lundbeck Zuclopenthixol Dihydrochloride Zuclopenthixol Acetate Zuclopenthixol Decanoate Antipsychotic Action And Clinical Pharmacology: Zuclopenthixol, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and dopamine D2 receptors. Zuclopenthixol also has high affinity for a1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and a2-adrenergic receptors. Pharmacokinetics: The pharmacokinetics of zuclopenthixol appear to be linear over…