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DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…

DIAMICRON® Servier Gliclazide Oral Hypoglycemic Action And Clinical Pharmacology: Gliclazide is an hypoglycemic agent of the sulfonylurea group. Its hypoglycemic action is related to an improvement in insulin secretion from the functioning beta cells of the pancreas. It potentiates the insulin release and improves the dynamics of insulin. Hemobiological properties of gliclazide have been observed in pharmacology studies. These are attributed to gliclazide action on the platelet behavior, prostaglandin equilibrium…

DIANE®-35 Berlex Canada Cyproterone Acetate – Ethinyl Estradiol Acne Therapy Action And Clinical Pharmacology: Diane-35 is a combination antiandrogen-estrogen for use in the treatment of androgen-dependent dermatological conditions in females. Cyproterone is a steroid compound with potent antiandrogenic, progestogenic and antigonadotrophic activity. It exerts its antiandrogenic effect by blocking androgen receptors. It also reduces androgen synthesis by a negative feedback effect on the hypothalamo-pituitary-ovarian systems. The estrogen component (ethinyl estradiol)…

DIAZEMULS® Pharmacia & Upjohn Diazepam Injectable Emulsion Anxiolytic – Sedative Action And Clinical Pharmacology: Diazemuls is an injectable emulsion of diazepam, a drug with known anxiolytic-sedative and muscle relaxant properties. Diazepam has been found useful for short-term symptomatic relief of excessive anxiety and tension in patients with anxiety neurosis, although anxiety and tension associated with the stresses of everyday life usually do not require treatment with anxiolytic drugs. Diazepam must…

DESYREL® DESYREL® DIVIDOSE Bristol Trazodone HCl Antidepressant Action And Clinical Pharmacology: Trazodone is a psychoactive compound with sedative and antidepressant properties. Its mechanism of action in humans is not clear. Trazodone is well absorbed after oral administration with peak plasma levels obtained within 0.5 to 2 hours after ingestion. Absorption is somewhat delayed and enhanced by food. The mean plasma elimination half-life is 4.4 hours for the period from 3…

DESQUAM-X® Preparations Westwood-Squibb Benzoyl Peroxide Acne Therapy Indications And Clinical Uses: A topical aid for the treatment of acne vulgaris. Contra-Indications: Known sensitivity to any of the components. Precautions: Avoid contact with eyes and mucous membranes. Observe patients carefully for possible local irritation or sensitivity during long-term topical therapy. Apply with caution on neck, circumoral and/or other sensitive areas. If excessive dryness or irritation occurs, discontinue use. May bleach colored…

DEXEDRINE® SmithKline Beecham Dextroamphetamine Sulfate Sympathomimetic Action And Clinical Pharmacology: Dextroamphetamine (dexamphetamine, d-amphetamine) sulfate is a sympathomimetic agent with indirect effects on adrenergic receptors. It has alpha-and beta-adrenergic activity. It has actions qualitatively similar to those of amphetamine sulfate but is approximately twice as potent. It has a marked stimulant effect on the CNS, particularly the cerebral cortex and the respiratory and vasomotor centers. Dextroamphetamine sulfate causes a lessening of…

DEXIRON™ Genpharm Iron Dextran Hematinic – Iron Supplement Action And Clinical Pharmacology: Iron dextran is absorbed from i.m. injection sites into the capillaries and the lymphatic system. Circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiologic forms…

DIABINESE™ Pfizer Chlorpropamide Oral Hypoglycemic Action And Clinical Pharmacology: Chlorpropamide is an orally active hypoglycemic agent which reduces blood sugar concentration without affecting glucose tolerance. It probably acts by stimulating insulin secretion in the presence of functioning pancreatic islet tissue. Chlorpropamide is absorbed readily from the gastrointestinal tract and is bound to plasma proteins. Within 1 hour after a single oral dose, it is detectable in the blood, and the…

DIABETA® Hoechst Marion Roussel Glyburide Oral Hypoglycemic Action And Clinical Pharmacology: The principal action of glyburide results in an increased insulin release from the beta cells of the pancreas. Other mechanisms leading to a reduction of blood glucose are also believed to be influenced by glyburide. The insertion of an alkylene chain on the benzene nucleus results in a product of very high potency. Schulz and Schmidt indicated that the…