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NASACORT® AQ Rhône-Poulenc Rorer Triamcinolone Acetonide Corticosteroid Action And Clinical Pharmacology: Triamcinolone acetonide is a potent anti-inflammatory steroid with strong topical and weak systemic activity. Triamcinolone acetonide is a more potent derivative of triamcinolone. Although triamcinolone itself is approximately 1 to 2 times as potent as prednisone in animal models of inflammation, triamcinolone acetonide is approximately 8 times more potent than prednisone. When administered intranasally in therapeutic doses, it has…

NAROPIN® Astra Ropivacaine HCl Local Anesthetic Action And Clinical Pharmacology: Mechanism of Action: Ropivacaine, a local anesthetic of the amino amide class, is supplied as the pure S-(-)-enantiomer. Ropivacaine, like other local anesthetics, causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibres. Ropivacaine has both anesthetic and analgesic effects. At high doses, surgical anesthesia…

NALCROM® Rhône-Poulenc Rorer Sodium Cromoglycate Antiallergic Agent Action And Clinical Pharmacology: Sodium cromoglycate seems to exert a stabilizing effect upon mast cells capable of releasing mediators. In gastrointestinal disease, the release of mediators causes a local inflammation which can either result in gastrointestinal symptoms or may allow absorption of antigenic material leading to systemic allergic reactions. It is most effective when given prior to antigen challenge. Sodium cromoglycate has no…

NAPROSYN® Roche Naproxen Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Naproxen has demonstrated anti-inflammatory, analgesic and antipyretic properties in classical animal test systems. In patients with rheumatoid arthritis, the anti-inflammatory action has been shown by a reduction in joint swelling, pain, and duration of morning stiffness, and by enhanced grip strength and increased mobility. It exhibits an anti-inflammatory effect even in adrenalectomized animals, and therefore its action is not mediated…

NALFON® Lilly Fenoprofen Calcium Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Fenoprofen has demonstrated anti-inflammatory, analgesic and antipyretic activities in animal studies. Although fenoprofen’s modes of action are unknown, in vitro tests have shown that it inhibits synthesis and/or release of prostaglandins; stabilizes lysosomes; inhibits platelet aggregation and platelet adhesiveness, and enhances fibrinolytic activity. All of these activities may have a role in the amelioration of inflammation, pain and fever….

MYCIFRADIN® Pharmacia & Upjohn Neomycin Sulfate Antibiotic Action And Clinical Pharmacology: Neomycin is an aminoglycoside antibiotic, active against many strains of Gram-negative bacteria. Neomycin is poorly absorbed from the normal gastrointestinal tract. The small absorbed fraction is rapidly distributed in the tissues and is excreted by the kidney in keeping with the degree of kidney function. The unabsorbed portion of the drug (approximately 97%) is eliminated unchanged in the feces….

NADOSTINE® Preparations Nadeau Nystatin Antifungal – Antibiotic Indications And Clinical Uses: Oral Suspension: Prevention and treatment of candidal infections of the mouth (thrush) and intestinal candidiasis in infants and children. Oral Tablets: Prevention and treatment of oral, esophageal and intestinal candidiasis. Protection against candidal overgrowth during antibiotic and/or corticosteroid therapy. Topical Products: Treatment of mucocutaneous candidiasis. The cream is usually used to treat intertriginous areas. Vaginal Products: Local treatment of…

NADOPEN-V® Nadeau Penicillin V Potassium Antibiotic Indications And Clinical Uses: Mild to moderately severe infections caused by penicillin V sensitive microorganisms including streptococcal pharyngitis, staphylococcal infection without bacteremia and pneumococcal infections. Therapy should be guided by bacteriologic sensitivity tests and clinical response. For prophylaxis following rheumatic fever and/or chorea. (Prophylaxis with oral penicillin on a continuing basis has proved effective in preventing recurrences of these conditions.) To prevent bacterial endocarditis…

MUMPSVAX® MSD Mumps Virus Vaccine, Live, Attenuated Mumps Prophylaxis Description: This vaccine is prepared from the Jeryl Lynn (B Level) strain, named after the patient from whom the virus was initially recovered. Mumpsvax is a sterile lyophilized preparation of the Jeryl Lynn (B level) strain of mumps virus. The virus was adapted to and propagated in cell cultures of chick embryo, free of avian leukosis, virus and other adventitious agents…

MUSTARGEN® MSD Mechlorethamine HCl Alkylating Agent Action And Clinical Pharmacology: Mechlorethamine, a biologic alkylating agent, has a cytotoxic action which inhibits rapidly proliferating cells. tag_IndicationsIndications Indications And Clinical Uses: Before using mechlorethamine see Contraindications, Warnings, Precautions, Adverse Effects and Dosage. Administered i.v., mechlorethamine is indicated for the palliative treatment of Hodgkin’s disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides and bronchogenic carcinoma….