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TAZOCIN® Wyeth-Ayerst Piperacillin Sodium–Tazobactam Sodium Antibiotic–b-lactamase Inhibitor Action and Clinical Tazocin is an injectable antibacterial combination consisting of the semisynthetic antibiotic piperacillin sodium and the b-lactamase inhibitor tazobactam sodium for i.v. administration. Piperacillin exerts bactericidal activity by inhibiting septum formation and cell wall synthesis. In vitro, piperacillin is active against a variety of gram-positive and gram-negative aerobic and anaerobic bacteria. Tazobactam is a b-lactamase inhibitor. Tazobactam, in combination with piperacillin…

TAZORAC™ Allergan Tazarotene Antipsoriasis Antiacne Action and Clinical Tazarotene is a retinoid prodrug which is converted to its active form, M1 (“tazarotenic acid”, or AGN 190299), by rapid de-esterification in most biological systems. “Tazarotenic acid” binds to and regulates gene expression through all three members of the RAR family of retinoid nuclear receptors, RAR a, RAR b, and RAR g, but shows selectivity for RAR b and RAR g.: Psoriasis:…

TEARDROPS® CIBA Vision Polyvinyl Alcohol–Povidone Artificial Tears Availability And Storage: Each mL contains: polyvinyl alcohol 14 mg and povidone 6 mg in a sterile, aqueous vehicle with chlorobutanol as preservative. Plastic squeeze bottles of 15 mL with dropper tips. TEARDROPS® CIBA Vision Polyvinyl Alcohol–Povidone Artificial Tears

Td POLIO ADSORBED (Tetanus and Diphtheria Toxoids Adsorbed and Inactivated Poliomyelitis Vaccine) Connaught Active Immunizing Agent Action and Clinical Pharmacology Tetanus is an acute and often fatal disease caused by an extremely potent neurotoxin produced by C. tetani. The organism is ubiquitous and its occurrence in nature cannot be controlled. Immunization is highly effective, produces long-lasting protection and is recommended for the whole population. Only 2 to 3 cases of…

TARO-DESOXIMETASONE Taro Desoximetasone Topical Corticosteroid Action and Clinical Pharmacology: Desoximetasone cream is a potent fluorinated corticosteroid. Topical corticosteroids are synthetic derivatives of cortisone which are effective when applied locally to control many types of inflammatory, allergic and pruritic dermatoses. Modifications to the chemical structure, such as fluorination, generally enhance both anti-inflammatory activity and increase the likelihood of adverse effects. The mechanism of anti-inflammatory activity of topical corticosteroids is generally unclear….

TAROSONE Taro Betamethasone Dipropionate Topical Corticosteroid Availability And Storage: Cream: Each g of cream contains: betamethasone 0.5 mg (as dipropionate USP) in a water miscible base of white petrolatum, mineral oil, cetostearyl alcohol, cetomacrogol 1 000, purified water, sodium phosphate monobasic, chlorocresol and propylene glycol with sodium hydroxide and phosphoric acid for pH correction. Tubes of 15 and 50 g. Jars of 450 g. Lotion: Each g of lotion contains:…

TASMAR™ Roche Tolcapone Antiparkinsonian – COMT-inhibitor Action And Clinical Pharmacology: Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated…

TAXOL™ Bristol-Myers Squibb Paclitaxel Antineoplastic Agent Caution: Paclitaxel should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel should be pretreated with corticosteroids, antihistamines, and H 2 antagonists (such as dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). Severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in patients…

TARGEL Preparations Odan Tar Compound Antipsoriatic Availability And Storage: Targel: Each g contains: liquor carbonis detergens 10% in a water washable gel base. Nonmedicinal ingredients: carbomer, perfume, propylene glycol, purified water and trolamine. Plastic jars of 100 g. Targel S.A.: Each g contains: liquor carbonis detergens 10% and salicylic acid 3% in a water washable gel base. Nonmedicinal ingredients: carbomer, perfume, propylene glycol, purified water and trolamine. Plastic jars of…

TARKA® Knoll Trandolapril – Verapamil HCl Antihypertensive Action And Clinical Pharmacology: Tarka is a formulation containing slow-release verapamil, a phenylalkylamine calcium channel blocker, along with immediate-release trandolapril, an angiotensin converting enzyme (ACE) inhibitor. Verapamil is a calcium channel blocker that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. Verapamil…