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| General
Information |

Common Name: |

Ginger |
|
Latin
Name:
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Zingiber
Officinale |
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Family:
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zingiberaceae |
| Other
Names: |
Based
on its origin:
 |
African
ginger
|
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Black
ginger
|
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Chochin
(Asian ginger).
|
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Gan
Jiang (Jamaican ginger).
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| Indications
& Historical Uses |
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For
more than 25 centuries, ginger has been used as both a spice and
an herbal remedy in the Far Eastern culture. Ginger is the mainstay
of Far Eastern medicine, wherein it has long been used to treat
digestive ailments, bloating, cramping, nausea, cough and cold
symptoms, sore throat, fever, headaches, inflammatory conditions
and kidney ailments. Modern-day uses for ginger in Eastern medicine
include the use of the herb to treat nausea (including motion
sickness and morning sickness of pregnancy), indigestion and loss
of appetite, cold and cough symptoms, sore throat, fever, high
cholesterol and high blood pressure and menstrual cramps. Ginger
is also a powerful anti-oxidant and anti-coagulant, and it can
be used to help increase absorption of other remedies.
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Indications:
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Nausea, vomiting.
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Motion sickness, vertigo.
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Morning sickness of pregnancy (approved for this use in
clinical guidelines - Society of Obstetricians & Gynecologists
of Canada).
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Loss of appetite.
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Dyspepsia, flatulence, indigestion (carminative).
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Prevention & treatment of cough, colds, influenza.
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Elevated cholesterol.
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Mild anticoagulant-blood thinning properties.
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Anti-oxidant.
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Menstrual cramps.
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Contraindications
& Precautions
Contraindications:
None known. Approved for use in controlling nausea & vomiting
in pregnancy. See
Caution.
Precautions:
None known
Adverse
Side Effects:
No reports of significant toxicity. Because ginger is known to
inhibit thromboxane a 2 synthesis, platelet aggregation may be
compromised. This may result in a bleeding tendency [very rare].
Drug
Interactions:
None known. However, because of potential inhibitory effect of ginger on
thromboxane synthesis, patients on anticoagulants (blood-thinning medications)
and those at risk for hemorrhage should avoid taking ginger |
| Dosage
Information |
|
How
Supplied:
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500
mg capsules. |
|
Dosage:
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500
mg two to three times per day of drug extract. |
| Pharmacology
|
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The
main components of ginger are the aromatic essential oils, anti-oxidants,
and the pungent oleo-resin. These aromatic or pungent compounds
have been identified as the phenylalkylketones, known as gingerols,
shogaols, and zingerone. These compounds provide most of the medicinal
properties of ginger. Gingerol has been found to have a similar
structure to acetyl salicylic acid, and these two compounds have
similar effects on prostaglandin production. This mechanism may
explain ginger's ability to reduce platelet aggregation and its
anti-thrombotic properties.
A
diterpenoid constituent of ginger has been shown to have activity
similar to a 5HT3 antagonist, similar to Zafran and other anti-emetic
drugs used as adjuncts to chemotherapy. 5HT3 receptors are found
in both the chemoreceptor trigger zone and on the vagal nerve
terminals in the intestine. The anti-emetic effects of ginger
are due to its local effect on the vagal receptors in the stomach.
In
a recent study, ginger was found to be more effective than drugs
in the treatment of nausea and motion sickness .
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Active
Ingredients:
|
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Phenyl
alkylketones.
|
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Volatile
oils
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| Origin |
|
The
main components of ginger are the aromatic essential oils, anti-oxidants,
and the pungent oleo-resin. These aromatic or pungent compounds
have been identified as the phenylalkylketones, known as gingerols,
shogaols, and zingerone. These compounds provide most of the medicinal
properties of ginger. Gingerol has been found to have a similar
structure to acetyl salicylic acid, and these two compounds have
similar effects on prostaglandin production. This mechanism may
explain ginger's ability to reduce platelet aggregation and its
anti-thrombotic properties.
A
diterpenoid constituent of ginger has been shown to have activity
similar to a 5HT3 antagonist, similar to Zafran and other anti-emetic
drugs used as adjuncts to chemotherapy. 5HT3 receptors are found
in both the chemoreceptor trigger zone and on the vagal nerve
terminals in the intestine. The anti-emetic effects of ginger
are due to its local effect on the vagal receptors in the stomach.
In
a recent study, ginger was found to be more effective than drugs
in the treatment of nausea and motion sickness.
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| Processing |
|
A
specially developed alcohol and water extraction is followed by
a unique micro-encapsulation process which preserves the volatile
active ingredients. The extract is concentrated about 3 times
compared to dry ginger and 30 times as compared to fresh ginger.
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| Scientific
References |
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Mowrey, D and Claysen D. E. (1982) Motion sickness, Ginger
and psychophysics: LANCET: March 20: 1; 655-657.
|
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Govindrajan, V. S. (1982) Ginger- Chemistry, Technology
and Quality Evaluation. CRC Critical Rev. in Science
and Nutrition. 17(3).
|
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Gujral, S. et al(1978): Effects of Ginger oleoresin on serum
cholesterol levels in cholesterol fed rats. Nutrition
Reports: 17(2) 183-189.
|
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Shoji
et al(1982): Cardiotonic principles of Ginger: J. Pharm.
Sci 71:1174-1175.
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Yamahara J. et al(1985): Cholegogic effects of Ginger and
its active constituents. J. Ethnopharm 113: 217-225.
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