tuber, or root , of the Devil's Claw plant contains a trio of
bitter-tasting iridoid glyocsides and beta-sitosterol which endow
the plant with its biological activity on the immune system, the
gastrointestinal tract , ,the micturition reflex, and the sensations
of pain and anxiety.
compounds increase the mobility of and increase the secretions
into the gastrointestinal tract and they modify the immune system
such that production of prostaglandins is reduced.
components of the plant, harpogoside and beta-sitosterol ,have
anti inflammatory properties. However whole devil's claw was found
to be superior to just isolated harpogoside.
studies have shown it to be more effective than aspirin, indomethacin,
and other synthetic and semi-synthetic anti-inflammatories, and
it is now known to be 6000 times more effective than western bitters
(e.g. gentian bitters) in the treatment of gastrointestinal disorders.
, the active components of devil's claw are very labile and mass-produced
tablets often contain harpagoside in the absence of other irido
glycosides or beta-sitosterol , thus rendering them biologically
inactive and ineffective.