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IMOVANE® Rhône-Poulenc Rorer Zopiclone Hypnotic Action And Clinical Pharmacology: Zopiclone, a cyclopyrrolone derivative, is a short-acting hypnotic agent. Zopiclone belongs to a novel chemical class which is structurally unrelated to existing hypnotics. However, the pharmacological profile of zopiclone is similar to that of the benzodiazepines. In sleep laboratory studies of 1- to 21-day duration in man, zopiclone reduced sleep latency, increased the duration of sleep and decreased the number of…

ImmuCyst® Connaught Bacillus Calmette-Guerin (BCG), substrain Connaught Antineoplastic Action And Clinical Pharmacology: When administered intravesically as a cancer therapy, BCG promotes a local acute inflammatory and sub-acute granulomatous reaction with histiocytic and leukocytic infiltration in the urothelium and lamina propria of the urinary bladder. The local inflammatory effects are associated with an elimination or reduction of superficial cancerous lesions of the urinary bladder. The antitumor effect appears to be T-lymphocyte-dependent….

IMMUNINE® VH Baxter Factor IX Concentrate (Human) Blood Coagulation Factor Action And Clinical Pharmacology: Coagulation factor IX is one of the clotting factors found in normal human blood and is required for normal clot formation. I.V. administration of Immunine VH, factor IX concentrate (human) vapor heated, Immuno provides an increase in plasma levels of factor IX and can temporarily correct the coagulation defect of patients with factor IX deficiency. The…

ILETIN® ILETIN® II PORK Lilly Insulin Diabetes Mellitus Therapy Description: Insulin is a protein hormone secreted by the beta cells of the pancreatic islets of Langerhans. The administration of suitable doses of insulin to patients with diabetes mellitus, along with controlled diet and exercise, temporarily restores their ability to metabolize carbohydrates, fats and proteins; to store glycogen in the liver; and to convert glucose to fat. When given in suitable…

ILOSONE® Lilly Erythromycin Estolate Antibiotic Action And Clinical Pharmacology: Erythromycin exerts its antibacterial action by binding the 50S ribosomal subunit of susceptible bacteria and suppressing protein synthesis. Erythromycin is usually bacteriostatic but may be bactericidal in high concentrations or against highly susceptible organisms. Indications And Clinical Uses: For the treatment of infections caused by susceptible strains of the designated microorganisms in the diseases listed below: Upper respiratory tract infections of…

IMDUR® Astra Isosorbide-5-Mononitrate Antianginal Action And Clinical Pharmacology: As with other organic nitrates, the principal pharmacological action of isosorbide-5-mononitrate, the major active metabolite of isosorbide dinitrate (ISDN), is relaxation of vascular smooth muscle and consequent dilation of peripheral arteries and veins, especially the latter. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge…

HYZAAR® MSD Losartan Potassium – Hydrochlorothiazide Angiotensin II Receptor Antagonist – Diuretic Action And Clinical Pharmacology: Hyzaar combines the actions of losartan potassium, an angiotensin II receptor antagonist, and that of a thiazide diuretic, hydrochlorothiazide. Losartan: Losartan antagonizes angiotensin II by blocking the angiotensin type 1 (AT1) receptor. Angiotensin II is the primary vasoactive hormone of the renin-angiotensin system. Its effects include vasoconstriction and the stimulation of aldosterone secretion by…

IDAMYCIN® Pharmacia & Upjohn Idarubicin HCl Antineoplastic Action And Clinical Pharmacology: Idarubicin, either as a single agent or in combination, has been shown to be a potent antileukemic agent capable of inducing complete remission in previously untreated and in relapsed and refractory acute non-lymphocytic leukemia (ANLL) including resistant patients, and in adult and pediatric relapsed patients with acute lymphoblastic leukemia (ALL). Idarubicin is a DNA-intercalating analog of daunorubicin which has…

IDARAC® Sanofi Floctafenine Anti-inflammatory – Analgesic Action And Clinical Pharmacology: Floctafenine, an anthranilic acid derivative, is a nonsteroidal anti-inflammatory agent with analgesic and anti-inflammatory properties. The analgesic activity is comparable to that of other mild analgesics in the relief of acute pain. Floctafenine has been shown to inhibit in vitro biosynthesis of prostaglandins PGE2 and PGF2a. Gastrointestinal bleeding determined by daily fecal blood loss, was shown in one clinical trial…

HYTRIN® Abbott Terazosin HCl Antihypertensive – Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH) Action And Clinical Pharmacology: Hypertension: The antihypertensive effect of terazosin is believed to be a direct result of peripheral vasodilation. Although the exact mechanism by which the lowering of blood pressure is achieved is not known, the relaxation of the vessels appears to be produced mainly by selective blockade of alpha-1-adrenoceptors. Benign Prostatic Hyperplasia (BPH): The reduction…