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FUCIDIN® Cream FUCIDIN® Ointment FUCIDIN® Intertulle Leo Fusidic Acid Sodium Fusidate Antibiotic Action And Clinical Pharmacology: Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-sRNA to protein on the ribosomes. Fusidic acid may be bacteriostatic or bactericidal depending on inoculum size. Although bacterial cells stop dividing almost within 2 minutes after contact with the antibiotic in vitro, DNA and RNA synthesis continue for 45 minutes…

FRISIUM® Hoechst Marion Roussel Clobazam Anticonvulsant for Adjunctive Therapy Action And Clinical Pharmacology: Clobazam is a 1,5-benzodiazepine with anticonvulsant properties. In general, the mode of antiepileptic action of clobazam is probably largely analogous to that of the 1,4-benzodiazepines . The differences between clobazam (a 1,5-benzodiazepine) and the 1,4-benzodiazepines in terms of therapeutic efficacy and neurotoxicity are possibly due to the variation in degree of the agonist action at the high…

FRAXIPARINE™ Sanofi Nadroparin Calcium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Nadroparin is a low molecular weight heparin. It is a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Of the low molecular weight heparins, nadroparin has the lowest mean molecular weight of approximately 4 300 daltons; 75 to 95% of the molecular masses are in…

FOSAMAX® MSD Alendronate Sodium Bone Metabolism Regulator Action And Clinical Pharmacology: Alendronate is an aminobisphosphonate that acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Pharmacokinetics: Absorption: Relative to an i.v. reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an…

FRAGMIN® Pharmacia & Upjohn Dalteparin Sodium Anticoagulant – Antithrombotic Action And Clinical Pharmacology: Dalteparin is an antithrombotic agent. Dalteparin sodium (low molecular weight heparin sodium) has an average molecular weight of 5 000. Dalteparin is produced through controlled nitrous acid de-polymerization of sodium heparin from porcine intestinal mucosa. It is composed of strongly acidic sulfated polysaccharide chains with an average molecular weight of 5 000 and about 90% of the…

FOLLOW-UP SOY® Nestl©, Carnation Soy Infant Formula Indications And Clinical Uses: A soy based, iron fortified formula designed to meet the nutritional needs of babies from 6 to 12 months of age who are already eating baby foods. Follow-Up soy formula is designed to be the liquid portion of a 6 to 12 month old baby’s diet. It is a nutritionally superior formula for milk-free feeding for babies 6 to…

FOLIC ACID * General Monograph, Pteroylglutamic Acid Folate Sodium Anemia Therapy Pharmacology: Folic acid is a B complex vitamin. After absorption from the gastrointestinal tract, folic acid is hepatically converted to tetrahydrofolic acid which is a cofactor in the biosynthesis of purines and thymidylates of nucleic acids. An exogenous source of folic acid is necessary for the maintenance of normal erythropoiesis. Folic acid deficiency can lead to meagloblastic and macrocytic…

FORADIL® Novartis Pharmaceuticals Formoterol Fumarate Bronchodilator Action And Clinical Pharmacology: Formoterol is a potent selective long-acting (12 hours) b2-adrenergic stimulant. It exerts a bronchodilator effect in patients with reversible airways obstruction. The effect is seen within 1 to 3 minutes and is still significant 12 hours after inhalation. Single dose studies have shown that formoterol is effective in preventing bronchospasm induced by allergen, exercise, cold air, histamine or methacholine challenge….

FOLLOW-UP® Nestlé, Carnation Infant Formula Indications And Clinical Uses: A cow’s milk based, iron fortified formula designed to meet the nutritional needs of babies from 6 to 12 months of age who are already eating baby foods. Follow-Up Formula is designed to be the liquid portion of a 6 to 12 month old baby’s diet. It is a nutritionally superior alternative to cow’s milk for the older baby. Follow-Up Formula…

FORANE® Zeneca Isoflurane Inhalation Anesthetic Action And Clinical Pharmacology: Isoflurane is an inhalation anesthetic whose low solubility (blood/gas partition coefficient equals 1.4), permits a rapid induction of and recovery from anesthesia. The mild pungency of isoflurane may limit the rate of induction, although excessive salivation or tracheobronchial secretions do not appear to be stimulated. The level of anesthesia may be changed rapidly with isoflurane. Pharyngeal and laryngeal reflexes are readily…