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Serentil Ampuls, Serentil Tablets, Serentil Concentrate (Boehringer Ingelheim) DESCRIPTION Serentil® (mesoridazine besylate), the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer which is effective in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses. Serentil® (mesoridazine besylate) is l0-[2(1-methyl-2-piperidyl) ethyl]-2-(methyl-sulfinyl)-phenothiazine [as the besylate]. Tablet, 10 mg, for oral administration ACTIVE INGREDIENT : mesoridazine (as the besylate), 10 mg. INACTIVE INGREDIENTS: acacia, carnauba wax, colloidal silicon dioxide,…

SEREVENT INHALATION AEROSOL DESCRIPTION SEREVENT (salmeterol xinafoate) Inhalation Aerosol contains salmeterol xinafoate as the racemic form of the 1-hydroxy-2-naphthoic acid salt of salmeterol. The active component of the formulation is salmeterol base, a highly selective beta 2 -adrenergic bronchodilator. The chemical name of salmeterol xinafoate is 4-hydroxy-(alpha) 1 -[[[6-(4-phenylbutoxy) hexyl]amino]methyl]-1,3-benzenedimethanol, 1-hydroxy-2-naphthalenecarboxylate. The molecular weight of salmeterol xinafoate is 603.8, and the empirical formula is C 25 H 37 NO 4…

SELEGILINE HYDROCHLORIDE (ELDEPRYL) DESCRIPTION ELDEPRYL (selegiline hydrochloride) is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl. The chemical name is: (R)-(-)- N,2 -dimethyl- N-2 -propynylphenethylamine hydrochloride. It is a white to near white crystalline powder, freely soluble in water, chloroform, and methanol, and has a molecular weight of 223.75. The structural formula is as follows: Each aqua blue capsule…

SANDOSTATIN LAR DEPOT DESCRIPTION Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl) propyl]-, cyclic (2->7)-disulfide; [R-(R*,R*)]. Sandostatin LAR® Depot (octreotide acetate for injectable suspension) is available in a vial containing the sterile drug product, which when mixed with diluent, becomes a suspension that is given as a…

SALAGEN DESCRIPTION SALAGEN® Tablets contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride is a hygroscopic, odorless, bitter tasting white crystal or powder which is soluble in water and alcohol and virtually insoluble in most non-polar solvents. Pilocarpine hydrochloride, with a chemical name of (3 S-cis )-2(3 H )-Furanone, 3-ethyldihydro-4-[(1-methyl-1 H -imidazol-5-yl)methyl] monohydrochloride, has a molecular weight of 244.72. Each SALAGEN® Tablet for oral administration contains 5 mg…

SABRIL® Hoechst Marion Roussel Vigabatrin Antiepileptic Action And Clinical Pharmacology: Vigabatrin is an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain. The mechanism of action of vigabatrin is attributed to irreversible enzyme inhibition of GABA-T, and consequent increased levels of the inhibitory neurotransmitter, GABA. Decreased serum levels of ALT and AST have been observed during…

SYNVISC® Biomatrix Hylan G-F 20 Viscosupplementation Description: Synvisc (hylan G-F 20) is a sterile, nonpyrogenic, elastoviscous fluid containing hylans. Hylans are derivatives of hyaluronan (sodium salt of hyaluronic acid) and consist of repeating disaccharide units of N-acetylglucosamine and sodium glucuronate. Synvisc contains hylan fluid and hylan gel slurry (8 mg±2 mg/mL) in buffered physiological sodium chloride solution (pH 7.2±0.3). Synvisc is biologically similar to hyaluronan. Hyaluronan is a component of…

SAIZEN DESCRIPTION Saizen® [somatropin (rDNA origin) for injection] is a human growth hormone produced by recombinant DNA technology. Saizen® has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone. Saizen® is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the human growth hormone…

RYTHMOL® Knoll Propafenone HCl Antiarrhythmic Agent Action And Clinical Pharmacology: Propafenone is an antiarrhythmic agent which possesses class 1c properties in the modified electrophysiological classification of Vaughan-Williams. It has a direct stabilizing action on myocardial cell membranes. The electrophysiological effect of propafenone manifests itself as a reduction of the upstroke velocity (Phase 0) of the monophasic action potential, while phase 4 spontaneous automaticity is depressed. Diastolic excitability threshold is increased…

SYNPHASIC® Searle Norethindrone-Ethinyl Estradiol Oral Contraceptive Action and Clinical Estrogen-progestogen combinations act primarily through the mechanism of gonadotropin suppression due to the estrogenic and progestational activity of their components. Although the primary mechanism of action is inhibition of ovulation, alterations in the cervical mucus and the endometrium may also contribute to effectiveness.IndicationsIndications: Indications And Clinical Uses: Prevention of pregnancy. Contra-Indications: History of or actual thrombophlebitis or thromboembolic disorders; history of…