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WELLFERON® Glaxo Wellcome Interferon alpha-n1 (Ins) Biological Response Modifier Action And Clinical Pharmacology: Wellferon is a highly purified blend of natural human alpha interferons, obtained from human lymphoblastoid cells following induction with Sendai virus. Wellferon resembles human leukocyte interferon in that it is a mixture of natural alpha subtypes but differs in that these are present in different proportions. It also differs from recombinant alpha interferon preparations made from bacteria…

WARTEC® Pharmascience Podofilox Antimitotic Agent Action And Clinical Pharmacology: Necrosis of visible tissue is observed following treatment of genital warts with podofilox. The exact mechanism of action is unknown. Podofilox is a metaphase inhibitor of dividing cells. Podofilox binds to at least one binding site on tubulin. This binding prevents the tubulin polymerization required for microtubule assembly. At higher concentrations podofilox also inhibits nucleoside transport through the cell membrane. The…

VIVOTIF BERNA™ Berna Products Typhoid Vaccine Live Oral Attenuated Ty21a Typhoid Prophylaxis Action And Clinical Pharmacology: S. typhi is the etiological agent of typhoid fever, an acute, febrile enteric disease. This vaccine will not afford protection against species of Salmonella other than S. typhi or other bacteria that cause enteric disease. The incidence of typhoid fever has declined steadily in Canada. Approximately 70 cases are reported annually. Many of these…

VIVOTIF BERNA® L VACCINE Berna Products Typhoid Vaccine Live Oral Attenuated Ty21a Typhoid Prophylaxis Action And Clinical Pharmacology: S. typhi is the etiological agent of typhoid fever, an acute, febrile enteric disease. This vaccine will not afford protection against species of Salmonella other than S. typhi or other bacteria that cause enteric disease. The incidence of typhoid fever has declined steadily in Canada. Approximately 70 cases are reported annually. Most…

VIVELLE® Novartis Pharmaceuticals Estradiol-17b Estrogen Description: Vivelle is a thin, circular, multilayer, transparent transdermal therapeutic system, i.e., an adhesive patch, containing estradiol-17b that is designed for application to an area of intact skin. The Vivelle patch comprises 3 layers. Proceeding from the visible surface toward the surface attached to the skin, these layers are: 1. A flexible semi-transparent backing film of polyurethane and ethylene vinyl alcohol polymer. 2. An adhesive…

VIVONEX® T.E.N. Novartis Nutrition Elemental Diet Indications And Clinical Uses: A high nitrogen, elemental (100% free amino acids) diet enriched with glutamine for patients with impaired digestion or absorption. Suggested indications include: inflammatory bowel disease, intestinal atresia, pancreatitis, fistula, partial obstruction, short-gut syndrome. Malnutrition and cachexia. Bowel preparation prior to diagnostic and surgical procedures. Transition diet between parenteral and normal oral feeding. Food sensitivities. Precautions: Do not administer parenterally. For…

VIVONEX® PEDIATRIC Novartis Nutrition Pediatric Elemental Diet Indications And Clinical Uses: Use in the dietary management of children with clinical conditions of short bowel syndrome, inflammatory bowel disease, malabsorption syndrome, cow’s milk protein enteropathy/sensitivity, select multiple trauma/major surgery, Crohn’s disease, gastrointestinal fistula, select pre/post surgery, intractable diarrhea and gastrointestinal disorder related to HIV/AIDS. Precautions: Do not administer parenterally. For use only under medical supervision. Nausea, vomiting, abdominal cramps, distention and…

VITAMIN D General Monograph Vitamin Action And Clinical Pharmacology: Vitamin D is a fat-soluble vitamin and has properties of both vitamins and minerals. The term vitamin D collectively refers to a group of structurally similar chemicals and their metabolites which includes alfacalcidol (1hydroxycholecalciferol), calcitriol (1,25-dihydroxycholecalciferol), cholecalciferol (vitamin D3), dihydrotachysterol (DHT) and ergocalciferol (vitamin D2). These agents have antirachitic properties. The biologic activity of 40 IU vitamin D equals that of…

VITAMIN B6 General Monograph Pyridoxine Vitamin Pharmacology: Vitamin B6 is a water soluble B complex vitamin which is present in many foods as pyridoxine, pyridoxal and pyridoxamine. These forms of vitamin B6 are converted in vivo to pyridoxal phosphate and pyridoxamine phosphate, which are essential coenzymes in the metabolism of certain amino acids such as tryptophan, in carbohydrate and lipid metabolism, and in the synthesis of heme and GABA, an…

VITAMIN K General Monograph, Phytonadione Hypoprothrombinemia Therapy Action And Clinical Pharmacology: Vitamin K compounds are fat soluble naphthoquinones. Phytonadione (vitamin K1) and vitamin K2 occur in a variety of natural materials and are synthesized by certain bacteria in the gastrointestinal tract; however, commercially prepared phytonadione is synthetically produced. Phytonadione possesses essentially the same type and degree of activity as naturally occurring vitamin K1. Vitamin K is necessary for synthesis in…