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BRONALIDE® Boehringer Ingelheim Flunisolide Corticosteroid Aerosol Action And Clinical Pharmacology: Flunisolide has demonstrated marked anti-inflammatory and anti-allergic activity in classical test systems. It is a corticosteroid which is several hundred times more potent in animal anti-inflammatory assays than the cortisol standard. When inhaled at therapeutic doses it has potent anti-inflammatory activity locally on the bronchial mucosa. Following i.v. administration in man of 2 mg flunisolide, plasma concentrations of 12 to…

BRADOSOL® BRADOSOL® EXTRA-STRENGTH Novartis Consumer Health Hexylresorcinol Antiseptic Indications And Clinical Uses: For the relief of sore throat. Precautions: If symptoms persist for more than 7 days, consult a physician. Dosage: 1 lozenge every 2 to 3 hours, as required. Not recommended for children under 3 years, unless on the advice of a physician. Availability And Storage: Bradosol: Each lozenge contains: hexylresorcinol 2.4 mg in a pleasant-tasting, candy-flavored base. Nonmedicinal…

BRETYLATE® Glaxo Wellcome Bretylium Tosylate Antiarrhythmic Action And Clinical Pharmacology: Bretylium is an adrenergic-neurone blocking agent. The mechanism by which it exerts its antiarrhythmic action is not fully understood. Although evidence has indicated that the benefit of bretylium in abating tachyarrhythmias may be due to its antiadrenergic properties, this has still not been firmly established. Some reports have even indicated that there is a clear-cut dissociation between the neuron-blocking and…

BREVIBLOC® Zeneca Esmolol HCl Beta-adrenergic Receptor Blocking Agent Action And Clinical Pharmacology: Esmolol is a beta-adrenergic receptor blocking agent with predominant blocking effect on beta-1 receptors. It does not possess significant intrinsic sympathomimetic or membrane stabilizing activity. Esmolol, which is administered only i.v., has a rapid onset and a short duration of action. Pharmacodynamics: In human electrophysiology studies, esmolol produced effects typical of a beta-blocker: a decrease in the heart…

BLOCADREN® Frosst Timolol Maleate Antihypertensive – Antianginal Agent Action And Clinical Pharmacology: Timolol is a beta-adrenergic receptor blocking agent. The mechanism of the antihypertensive effect of beta- adrenergic receptor blocking agents has not yet been established. Among the factors that may be involved are: competitive ability to antagonize catecholamine-induced tachycardia at the beta receptor sites in the heart, thus decreasing cardiac output; inhibition of renin release by the kidneys; inhibition…

BONAMINE™ Pfizer Meclizine HCl Antiemetic Action And Clinical Pharmacology: Meclizine has antihistaminic and anticholinergic properties. The site and mechanism of action of meclizine in controlling vertigo arising from various conditions, have not been clearly defined. Pharmacological studies conducted with other antihistamines show that the peripheral labyrinthine structures may be the site of action. Indications And Clinical Uses: For prophylaxis and symptomatic relief of nausea, vomiting and vertigo associated with motion…

BONEFOS® Rh´ne-Poulenc Rorer Clodronate Disodium Bone Metabolism Regulator – Antihypercalcemic Agent Action And Clinical Pharmacology: Clodronate belongs to the class of bisphosphonates which bind to hydroxyapatite and inhibit formation and dissolution of calcium crystals in vitro. Bisphosphonates including clodronate act on the bony skeleton causing reduction of normal and abnormal bone resorption. Clodronate alters the activities of osteoclasts and osteoblasts and the balance of bone resorption and bone formation is…

BOTOX® Allergan Botulinum Toxin Type A Neuromuscular Paralytic Agent Action And Clinical Pharmacology: Botulinum toxin type A blocks neuromuscular conduction by binding to receptor sites on motor nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. When injected i.m. at therapeutic doses, botulinum toxin type A produces a partial chemical denervation of the muscle resulting in localized muscle paralysis. When chemically denervated, the muscle may atrophy, axonal…

BLENOXANE® Bristol Bleomycin Sulfate Antineoplastic – Antibiotic Action And Clinical Pharmacology: Although the exact mechanism of action of bleomycin is unknown, available evidence indicates that the main mode of action is inhibition of DNA synthesis with some evidence of inhibition of RNA and protein synthesis. The major route of excretion of bleomycin is the kidney, with 60 to 70% of an administered dose recovered in the urine as active bleomycin….

BLEOMYCIN SULFATE USP Faulding Antineoplastic Action And Clinical Pharmacology: Experiments with isolated DNA have shown that bleomycin binds to the DNA molecule and cleaves it. This results in the inhibition of DNA synthesis. There is also evidence of lesser inhibition of RNA and protein synthesis. Bleomycin exhibits a wide spectrum of in vitro and in vivo activity. It demonstrates inhibition of DNA synthesis in E. coli, B. subtilis, Ehrlich ascites…