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HEPARINS: LOW MOLECULAR WEIGHT General Monograph, Dalteparin Enoxaparin Nadroparin Tinzaparin Anticoagulant Action And Clinical Pharmacology: Low molecular weight heparins (LMWHs) are fragments of heparin produced by enzymatic or chemical depolymerization. They have an average molecular weight of 4 000 to 5 000 daltons (range 1 000 to 10 000 daltons) which is approximately one-third that of standard heparin. Most heparin molecules with molecular weights smaller than 5 400 daltons are…

HEXABRIX® 200 HEXABRIX® 320 Mallinckrodt Ioxaglate Meglumine – Ioxaglate Sodium Radiopaque Medium Action And Clinical Pharmacology: Following intravascular injection, Hexabrix is rapidly transported through the circulatory system to the kidneys and is excreted unchanged in the urine. The pharmacokinetics of intravascularly administered radiopaque contrast media are usually best described by a two compartment model with a rapid alpha phase for drug distribution and a slower beta phase for drug elimination….

HEXADROL® PHOSPHATE INJECTION Organon Teknika Dexamethasone Sodium Phosphate Corticosteroid Action And Clinical Pharmacology: After administration of the injection, dexamethasone sodium phosphate is rapidly converted into dexamethasone. This is a synthetic glucocorticoid which has 7 times the anti-inflammatory potency of prednisolone. Like other glucocorticoids, dexamethasone also has antiallergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has practically no water and salt-retaining properties and is, therefore, particularly suitable for use in patients…

HEALON® HEALON® GV Pharmacia & Upjohn Sodium Hyaluronate Ophthalmosurgical Aid Description: Sodium hyaluronate is a sterile, nonpyrogenic, viscoelastic preparation of a highly purified, noninflammatory, high molecular weight fraction of sodium hyaluronate. Healon contains 10 mg/mL of sodium hyaluronate 5 000 and Healon GV contains 14 mg/mL of sodium hyaluronate 7 000 dissolved in physiological sodium chloride-phosphate buffer (pH 7.0 to 7.5). This high molecular weight polymer is made up of…

HEPARIN LEO® Leo Heparin Sodium Anticoagulant Action And Clinical Pharmacology: Heparin is an anticoagulant which prevents the formation of thrombin by accelerating the neutralization of activated coagulation factors by naturally occurring inhibitors. Indications And Clinical Uses: For the prophylaxis and management of intravascular clotting and embolism in susceptible patients. It is also used in extra-corporeal circulation, i.e. heart-lung and renal dialysis machines and blood transfusions. Contra-Indications: Hemorrhagic disorders and patients…

HALOG® Preparations Westwood-Squibb Halcinonide Topical Corticosteroid Indications And Clinical Uses: Halcinonide, a synthetic fluorinated corticosteroid, is indicated for topical application for the relief of the inflammatory manifestations of acute or chronic corticosteroid responsive dermatoses; under occlusion, in the management of recalcitrant cases of psoriasis and neurodermatitis. Contra-Indications: Tuberculous, fungal and most viral lesions of the skin (including herpes simplex, vaccinia, and varicella). Patients with history of hypersensitivity to any of…

HALFAN™ SmithKline Beecham Halofantrine HCl Antimalarial Action And Clinical Pharmacology: Halofantrine is schizonticidal and exerts its action at the erythrocytic stage of the life cycle (trophozoite and schizont). It is not effective against exo-erythrocytic (hepatic) schizonts or against the sporozoite, merozoite or gametozoite stages of the life cycle of Plasmodium species investigated. The precise mechanism of action of halofantrine is not certain. It has been hypothesized that halofantrine interferes with…

HALOTESTIN® Pharmacia & Upjohn Fluoxymesterone Androgenic – Anabolic Steroid Action And Clinical Pharmacology: Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body…

HABITROL® Novartis Consumer Health Nicotine Smoking Cessation Aid Action And Clinical Pharmacology: Habitrol delivers S(-)-nicotine, the active component of tobacco smoke, transdermally into the systemic circulation, continuously over 24 hours. Habitrol releases S(-)-nicotine in controlled amounts at a rate sufficient to produce plasma nicotine concentrations comparable to trough levels observed in smokers before smoking a cigarette. Because of the low, continuous delivery of S(-)-nicotine through the skin, Habitrol does not…

HALCION® Pharmacia & Upjohn Triazolam Hypnotic Action And Clinical Pharmacology: Triazolam is a benzodiazepine hypnotic with a very short elimination half-life (about 3 hours). In sleep laboratory studies of 1 to 21 days duration, triazolam significantly decreased sleep latency, increased duration of sleep and decreased the number of nocturnal awakenings. However, after 2 weeks of consecutive nightly administration, the drug’s effect on total wake time was decreased, and the values…