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PARAFON FORTE® Johnson & Johnson• Merck Chlorzoxazone – Acetaminophen Muscle Relaxant – Analgesic Action And Clinical Pharmacology: Parafon Forte tablets combine the muscle-relaxant effect of chlorzoxazone with acetaminophen, a well-known analgesic. Chlorzoxazone is a centrally acting agent for painful musculoskeletal conditions. Data available from animal experiments, as well as human study, indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where…

PAMPRIN® PAMPRIN® Extra Strength PAMPRIN® PMS Chattem Pamabrom – Pyrilamine Maleate – Acetaminophen Diuretic – Antihistamine – Analgesic Indications And Clinical Uses: For temporary relief of symptoms accompanying premenstrual syndrome such as cramps, headache, irritability, backache and mild to moderate aches and pains. To reduce the temporary excess water frequently associated with the premenstrual period. Pamprin is most effective if taken at the first sign of discomfort, usually a few…

PANOCAINE® Hoechst Marion Roussel Benzocaine – Tetracaine HCl Oral Topical Anesthetic Action And Clinical Pharmacology: Panocaine is a local anesthetic of the ester type which rapidly produces surface anesthesia following application to the mucosa of the oral cavity in clinical dentistry. Panocaine has a short duration of action and is ineffective when applied to intact skin. Indications And Clinical Uses: For use in the oral cavity for minimizing the pain…

Brand Names: PALAFER® Manufacturer: SmithKline Beecham Generic Name: Ferrous Fumarate Use: Anemia Therapy Indications And Clinical Uses Increased iron requirements as in childhood, adolescence, and pregnancy; blood losses, overt or occult. Characterized microcytic hypochromic anemia; faulty iron absorption following gastrectomy; iron loss due to menstruation, sub-clinical iron deficiencies in adolescent girls due to precarious iron balance, and geriatrics. Contraindications Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of…

PALUDRINE® Wyeth-Ayerst Proguanil HCl Antimalarial Action And Clinical Pharmacology: Proguanil is metabolized in the body to the antimalarial drug cycloguanil, a triazine derivative, which inhibits plasmodial dihydrofolate reductase thus indirectly inhibiting synthesis of nucleic acids in the parasite. Proguanil, like pyrimethamine, is active against pre-erythrocytic forms and is a slow blood schizontocide. It also has some sporonticidal activity, rendering the gametocytes noninfective to the mosquito vector. Pharmacokinetics: Proguanil is well…

PYRIDIUM® Parke-Davis Phenazopyridine HCl Urinary Analgesic Action And Clinical Pharmacology: Phenazopyridine is excreted in the urine where it exerts a topical analgesic effect on the mucosa of the urinary tract. This action helps to relieve pain, burning, urgency and frequency. The precise mechanism of action is unknown. Pharmacokinetics: The pharmacokinetic properties of phenazopyridine have not been determined. Phenazopyridine and its metabolites are rapidly excreted by the kidneys. In a small…

PALAFER® CF SmithKline Beecham Ferrous Fumarate Compound Prenatal Supplement Indications And Clinical Uses: For the treatment of hypochromic anemia and avitaminosis C and to prevent megaloblastic anemia of pregnancy due to folic acid depletion. Contra-Indications: Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of hemolytic anemias unless an iron-deficient state also exists, since storage of iron with a possible exogenous hemosiderosis can result. Precautions: Where anemia exists, its…

PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PURIFIED PROTEIN DERIVATIVE Connaught PPD-B (Mantoux) Diagnostic Antigen Indications And Clinical Uses: If there is reason to believe that an individual is infected with a mycobacterium other than M. tuberculosis var. hominis, as an added diagnostic procedure, PPD-B (Mantoux), 0.05 g per test dose may be injected using Tuberculin PPD (Mantoux), 5 TU (bioequivalent) per test dose, as a control. Injections are usually made in the same forearm not less…

PURINETHOL® Glaxo Wellcome Mercaptopurine Antileukemic Action And Clinical Pharmacology: Clinical studies have shown the absorption of an oral dose of mercaptopurine in man is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown. I.V. administration of an investigational preparation of mercaptopurine revealed a plasma half-disappearance time of 21 minutes in children and 47 minutes in adults. The volume of distribution usually exceeded that…